Project Description
Public­ations
A. Wisskirchen K*, Kah J*, Malo A, Asen T, Volz T, Allweiss L, Wettengel JM, Lütgehetmann M, Urban S, Bauer T, Dandri M*, Protzer U*. 2019. T-Cell Receptor Grafting allows Virological Control of Hepatitis B Virus Infection. J Clin Invest. 129(7):2932-2945. * equal contribution.
B. Xia Y, Schlapschy M, Morath⁠ V, Roeder N⁠, Vogt EI, Stadler D⁠, Cheng X⁠⁠, Dittmer U⁠, Sutter K⁠, Heikenwalder M⁠, Skerra A⁠, Protzer U. 2019. PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice. Antiviral Research. 161:134-143
C. Bockmann JH, Stadler D, Xia Y, Ko C, Wettengel JM, Schulze zur Wiesch J, Dandri M, Protzer U. 2019. Compar-ative analysis of the antiviral effects mediated by type I and III interferons in hepatitis B virus infected hepato-cytes. J Inf Dis 220(4):567-577
D. Wing P, Davenne T, Wettengel J, Lai AG, Zhuang X, Chakraborty A, D’Arienzo V, Kramer C, Ko C, Harris LM, Schreiner S, Higgs M, Roessler S, Parish JL, Protzer U, Balfe P, Rehwinkel J, McKeating J.2019. A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis. Life Sci Alliance. 2(2).
E. Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D. 2018. Outcome of anti-viral immunity in the liver is shaped by the level of an-tigen expressed in infected hepatocytes. Hepatology. 8(6):2089-2105.
F. Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. 2018. Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. J Hepatol. 69(6):1231-1241.
G. Burwitz B*, Wettengel J*, Mück-Häusl M, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Reed N, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U*, Sacha J*. 2017. Hepatocytic Expression of Human Sodium-Taurocholate Cotransporting Polypeptide Enables Hepatitis B Virus Infection of Macaques. Nat Commun. 8(1): 2146. * equal contribution.
H. Li Y*, Xia Y*, Han M, Chen G, Zhang D, Thasler W, Protzer U*, Ning Q*. 2017. IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against HBV Infection. Sci Rep. 7(1):12715. * equal contribu-tion.
I. Xia Y*, Stadler D*, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chao W-M, Wettengel J, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Thasler WE, Heikenwalder M, Protzer U. 2016. Interferon-γ and Tumor Necrosis Factor-α Produced by T cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology. 150(1):194-202.
J. Lucifora J*, Xia Y*, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl M, Koppensteiner H, Li Y, Makowska Z, Volz T, Remouchamps C, Chou W-M, Thasler W, Hüser N, Durantel D, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M*, Protzer U*. 2014. Specific and non-hepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343(6176):1121-1128. * equal contribution.