Scientific Vita
Publi­cations
Con­tact

Dr.

Marco Binder

Academic Education and University Degree

2003 - 2007
Ph.D. thesis, Molecular Virology, Department of Infectious Diseases, Heidelberg University, Germany (highest grade: summa cum laude); supervised by Dr. Volker Lohmann / Prof. Ralf Bartenschlager
2001 - 2002
Diploma work, Biology, Stony Brook University (MCB program, Prof. Eckard Wimmer), New York, USA and University of Constance; Germany, supervised Prof. Patrick Hearing and Prof. Rolf Knippers (highest grade “sehr gut”)
1998 - 2003
Study of Biology at University of Constance, Germany

Employment

Since 2014
Independent group leader, division “Virus-associated carcinogenesis”, German Cancer Research Center Heidelberg, Germany
2011 - 2014
Research group leader, Dept. for Infectious Diseases, Heidelberg University, Germany
2009 - 2010
Postdoctoral Fellowship of the Medical Faculty Heidelberg, Germany associated with the Dept. for Infectious Diseases
2007 - 2008
Postdoc, Dept. Infectious Diseases, Heidelberg University, Germany
Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A, Bartenschlager R. 2015. Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. J Hepatol 63:829-37
Binder M, Sulaimanov N, Clausznitzer D, Schulze M, Hüber CM, Lenz SM, Schlöder JP, Trippler M, Bartenschlager R, Lohmann V, Kaderali L. 2013. Replication vesicles are load- and choke- points in the hepatitis C virus lifecycle. PLoS Pathog 9: e1003561.
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G. 2012. Viral immune modulators perturb the human molecular network by common and unique strategies. Nature 487:486-90.
Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Windisch MP, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R. 2012. Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology 56: 2082–2093.
Binder M, Eberle F, Seitz S, Mücke N, Hüber CM, Kiani N, Kaderali L, Lohmann V, Dalpke A Bartenschlager R. 2011. Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem 286: 27278–27287.
Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet- Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM.. 2011. Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology 54: 1157–1166.
Eberle F, Sirin M, Binder M, Dalpke A. 2009. Bacterial RNA is recognized by different sets of immunoreceptors. Eur J Immunol 39: 2537–2547.
Binder M, Quinkert D, Bochkarova O, Klein R, Kezmic N, Bartenschlager R, Lohmann V. 2007. Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol 81: 5270–5283.
Binder M, Kochs G, Bartenschlager R, Lohmann V. 2007. Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology 46: 1365–1374
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167–1172.
Address
Division Virus-associated carcinogenesis (F170)
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
eMail
m.binder@dkfz.de