Scientific Vita
Publi­cations
Con­tact

PD Dr.

Christoph Neumann-Haefelin

Clinical education and employment

since 2011
Attending in Internal Medicine, Department of Medicine II, University Hospital Freiburg, Germany
2011
Internal Medicine Board exam
since 2003
MD at the Department of Medicine II, University Hospital Freiburg, Germany (Director: Prof. Dr. Dres. h.c. H.E. Blum; since 2013 Prof. Dr. R. Thimme)
2003
Clinical observer (PJ), University of South Florida, Tampa, USA, and Kantonsspital Winterthur, Switzerland
1996 - 2003
Medical student, Albert Ludwigs University Freiburg, Germany

Scientific education

2012
Habilitation in Medicine, Albert Ludwigs University Freiburg, Germany since 2010 Emmy Noether Group leader, Department of Medicine II, University Hospital Freiburg, Germany
2009
Sabbatical at the Ragon Institute of MGH, MIT, and Harvard, Boston, USA (group of Prof. Todd M. Allen)
2003 - 2009
Research Associate in the group of Prof. Dr. R. Thimme, Department of Medicine II, University Hospital Freiburg, Germany
1998 - 2001
Doctoral thesis in the group of Prof. Dr. M. Müller, Institute of Biochemistry, University of Freiburg, Germany (grade: summa cum laude)
Nitschke K, Barriga A, Schmidt J, Timm J, Viazov S, Kuntzen T, Kim AY, Lauer GM, Allen TM, Gaudieri S, Rauch A, Lange CM, Sarrazin C, Eiermann T, Sidney J, Sette A, Thimme R, López D, Neumann-Haefelin C. 2014. HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. J Hepatol 60: 22-9.
Ashraf S, Nitschke K, Warshow UM, Brooks CR, Kim AY, Lauer GM, Hydes TJ, Cramp ME, Alexander G, Little AM, Thimme R, Neumann-Haefelin C, Khakoo SI. 2013. Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection. Hepatology 58:881-9.
Schmidt J, Iversen AK, Tenzer S, Gostick E, Price DA, Lohmann V, Distler U, Bowness P, Schild H, Blum HE, Klenerman P, Neumann-Haefelin C*, Thimme R*. 2012. Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus- specific CD8+ T-cell epitope. PLoS Pathog 8:e1003042. *equal contribution
Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet- Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM. 2011. Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology 54: 1157-1166.
Schmidt J, Neumann-Haefelin C, Altay T, Gostick E, Price DA, Lohmann V, Blum HE, Thimme R. 2011. Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency. J Virol 85:5232-6.
Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper M, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. 2010. The protective effect of HLA-B27 in hepatitis C virus infection requires presence of a genotype-specific immunodominant CD8+ T cell epitope. Hepatology 51: 54-62.
Dazert E*, Neumann-Haefelin C*, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen, HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. 2009. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest 119: 376-386. *equal contribution
Neumann-Haefelin C, Timm J, Spangenberg HC, Wischniowski N, Nazarova N, Kersting N, Roggendorf M, Allen TM, Blum HE, Thimme R. 2008. Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology 47:1824-36.
Neumann-Haefelin C, Frick DN, Wang JJ, Pybus OG, Salloum S, Narula GS, Eckart A, Biezynski A, Eiermann T, Klenerman P, Viazov S, Roggendorf M, Thimme R, Reiser M, Timm J. 2008. Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level. J Virol 82:3438-51.
Neumann-Haefelin C, McKiernan S, Ward S, Viazov S, Spangenberg HC, Killinger T, Baumert TF, Nazarova N, Sheridan I, Pybus O, von Weizsäcker F, Roggendorf M, Kelleher D, Klenerman P, Blum HE, Thimme R. 2006. Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. Hepatology 43:563-72.
Address
Department of Medicine II
University Hospital Freiburg
Hugstetter Strasse 55
79106 Freiburg
eMail
christoph.neumann-haefelin@uniklinik-freiburg.de