Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Percy A. Knolle

Academic Education and University Degrees

2000
Habilitation, University of Heidelberg, Heidelberg, Germany, mentor Prof.Meuer
1997
“Facharzt für Innere Medizin”
1992 - 1997
Assistant 1st Medical Clinic, University of Mainz, Prof. Meyer zum Büschenfelde, Mainz, Germany
1991 - 1992
Postdoc with BASF-Research Branch in Boston, USA
1989 - 1991
Experimental MD, German Cancer Research Center; supervised by Prof.Meuer, Heidelberg, Germany
1982 - 1988
Study of Medicine at the Universities of Frankfurt, Birmingham, Paris, Geneva, Strasbourg

Employment

Since 2013
Director Institute of Molecular Immunology and Experimental Oncology, Technische Universität München, Germany
2002 - 2012
Director Institute of Molecular Medicine, University of Bonn, Germany
1997 - 2002
Independent group leader at ZMBH (Prof. Schaller), Heidelberg, Germany
1992 - 1997
Assistant 1st Medical Clinic, University of Mainz, Prof. Meyer zum Büschenfelde, Germany
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M*, Knolle PA*. 2013. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol 14: 574-583.*co-corresponding authors
Böttcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Hochst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath MF, Busch DH, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze JL, Diehl L, Knolle PA. 2013. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell reports 3: 779-795.
Protzer U, Maini MK, Knolle PA. 2012. Living in the liver: hepatic infections. Nat Rev Immunol 12: 201-213.Review.
Wohlleber D, Kashkar H, Gartner K, Frings MK, Odenthal M, Hegenbarth S, Borner C, Arnold B, Hammerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Kronke M, Knolle PA. 2012. TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Reports 2: 478-487.
Huang LR, Gabel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U. 2012. Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology 142: 1447-1450 e1443.
Thomson AW, Knolle PA. 2010. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol 10: 753-766. Review.
Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase MJ, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle PA. 2010. Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 138: 336-346.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. 2009. The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med 206: 2079-2089.
Diehl L, Schurich A, Grochtmann R, Hegenbarth S, Chen L, Knolle PA. 2008. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology 47: 296-305.
Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, Groettrup M, Momburg F, Arnold B, Knolle PA. 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med 2000 6: 1348-1354.
Address
Institute of Molecular Immunology and Experimental Oncology
Klinikum München rechts der Isar der TUM
Ismaningerstr. 22
81675 München
eMail
percy.knolle@tum.de