Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Percy A. Knolle

Academic Education and University Degrees
2000
Habilitation, University of Heidelberg, Heidelberg, Germany, mentor Prof.Meuer
1997
“Facharzt für Innere Medizin”
1992 - 1997
Assistant 1st Medical Clinic, University of Mainz, Prof. Meyer zum Büschenfelde, Mainz, Germany
1991 - 1992
Postdoc with BASF-Research Branch in Boston, USA
1989 - 1991
Experimental MD, German Cancer Research Center; supervised by Prof.Meuer, Heidelberg, Germany
1982 - 1988
Study of Medicine at the Universities of Frankfurt, Birmingham, Paris, Geneva, Strasbourg

Employment
Since 2013
Director Institute of Molecular Immunology and Experimental Oncology, Technische Universität München, Germany
2002 - 2012
Director Institute of Molecular Medicine, University of Bonn, Germany
1997 - 2002
Independent group leader at ZMBH (Prof. Schaller), Heidelberg, Germany
1992 - 1997
Assistant 1st Medical Clinic, University of Mainz, Prof. Meyer zum Büschenfelde, Germany
1. Wratil PR, Stern M, Priller A, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle PA*, Keppler OT*, Protzer U*. Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern. Nature Medicine 2022, 28: 496-503. 10.1038/s41591-022-01715-4 *equal contribution
2. Koerber N, Priller A, Yazici S, Bauer T, Winter C, Ruland J, Gerhard M, Haller B, Christa C, Zelger O, Roggendorf H, Halle M, Erber J, Lingor P, Keppler O, Zehn D, Protzer U, Knolle PA. Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents. Nature Communications 2022, 13: 153. 10.1038/s41467-021-27649-y
3. Dudek M, Pfister D, Donakonda S, Tilg H, Thimme R, Bottler T, Tacke F, Dufour JF, Haller D, Murray PJ, Heeren R, Zehn D, Böttcher JP, Heikenwälder M, Knolle PA. Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH. Nature 2021, 592: 444-449. 10.1038/s41586-021-03233-8
4. Pfister D, Nunez NG, Pinyol R, Govaere O, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle PA, Becher B, Llovet JM, Heikenwälder M. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature 2021, 592: 450-456. 10.1038/s41586-021-03362-0
5. Baumann T, Dunkel A, Schmid C, Schmitt S, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA*, Höchst B*. Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal. Nature Immunology 2020, 21: 555-566. 10.1038/s41590-020-0666-9 *equal contribution
6. Welz M, Eickhoff S, Abdullah Z, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle PA*, Wohlleber D*, Kastenmuller W*. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nature Communications. 2018, 9: 4805. 10.1038/s41467-018-07213-x *equal contribution
7. Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Heikenwalder M, Fatkenheuer G, Lang PA, Hartmann P, Knolle PA*, Schultze JL*. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nature Immunology. 2016, 17: 593-603. 10.1038/ni.3399 *equal contribution
8. Huang LR, Wohlleber D, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nature Immunology. 2013, 14: 574-583. 10.1038/ni.2573
9. Burgdorf S, Kautz A, Bohnert V, Knolle PA, Kurts C. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 2007, 316: 612-616. 10.1126/science.1137971
10. Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, Groettrup M, Momburg F, Arnold B, Knolle PA. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nature Medicine 2000, 6: 1348-1354. https://doir.org:10.1038/82161
Address
Institute of Molecular Immunology and Experimental Oncology
Klinikum München rechts der Isar der TUM
Ismaningerstr. 22
81675 München
eMail
percy.knolle@tum.de