Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Roland Eils

Academic Education and University Degrees

1992 - 1995
PhD thesis in Mathematics and Computing, Heidelberg University, Germany, supervised by Prof. Jäger, Prof. Bock, Heidelberg University, Germany
1984 - 1990
Diploma in Math and Informatics, RWTH Aachen, Germany

Employment

Since 2004
Ordinarius of Bioinformatics & Functional Genomics, Heidelberg University, Germany
Since 2002
Division Head "Theoretical Bioinformatics" German Cancer Research Center Heidelberg, Germany
2000 - 2002
Head of the bioinformatics group „Intelligent bioinformatics systems“,German Cancer Research Center Heidelberg, Germany
1996 - 1999
Group Head, “Structure & Function in Cell Biology”, Heidelberg University, Germany
1996
Guest Researcher at Université de Grenoble, France
Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bar D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sultmann H, Provenzano M, Cancer I.P.o.E.O.P., Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G*, Eils R*, Plass C*, Santoro R* . 2015. BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nature Genetics 47: 22-30. *co-corresponding authors
Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R. 2014. Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis. Science Signaling 7: ra23
Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R. 2013. Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell 155: 567-581.
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R*, Lichter P*, Pfister SM*; International Cancer Genome Consortium PedBrain Tumor Project. 2013. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Genetics 45: 927-932. *co-corresponding authors
Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, Russell RB, Coco S, Tonini GP, Schüller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann MU, Frühwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, Collins VP, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo ML, Korbel JO, Korshunov A, Eils R*, Pfister SM*, Lichter P*. 2012.Dissecting the genomic complexity underlying medulloblastoma. Nature 488: 100-105. *co- corresponding authors
Neumann L, Pforr C, Beaudouin J, Pappa A, Fricker N, Krammer PH, Lavrik IN, Eils R. 2010. Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Molecular Systems Biology 6: 352.
Busch H, Camacho-Trullio D, Rogon Z, Breuhahn K, Angel P, Eils R*, Szabowski A*. 2008. Gene network dynamics controlling keratinocyte migration. Molecular Systems Biology 4: 199. *co-corresponding authors
Bacher CP, Guggiari M, Brors B, Augui S, Clerc P, Avner P, Eils R*, Heard E*. 2006. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat Cell Biol 8: 293-299. *co-coresponding authors.
Bentele M, Lavrik I, Ulrich M, Stosser S, Heermann DW, Kalthoff H, Krammer PH, Eils R. 2004. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol 166: 839-851.
Gerlich D, Beaudouin J, Gebhard M, Ellenberg J, Eils R. 2001. Four-dimensional imaging and quantitative reconstruction to analyse complex spatiotemporal processes in live cells. Nat Cell Biol 3: 852-855.
Address
Department for Bioinformatics & Functional Genomics,
Institute for Pharmacy and Molecular Biology (IPMB) and BioQuant Heidelberg University
Im Neuenheimer Feld 267
69120 Heidelberg
eMail
roland.eils@bioquant.uni-heidelberg.de