Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Veit Hornung

Academic Education and University Degrees

2004
MD doctoral thesis, University of Munich, LMU, Germany
1996 - 2003
Study of Medicine at the University of Munich, LMU, Germany including rotations at Harvard University (Boston, USA) and University of Zürich (Zürich, Switzerland).

Employment

10/2015
Chair of Immunobiochemistry, Gene Center and Department of Biochemistry Ludwig-Maximilians-University Munich (LMU), Germany
2014 - 2015
Director, Institute of Molecular Medicine, University Hospital, University of Bonn, Germany
2008 - 2013
Professor of Clinical Biochemistry (W2), Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Germany
2006 - 2008
Postdoctoral research fellow in the laboratories of Prof. Dr. Eicke Latz and Prof. Dr. Kate Fitzgerald in the Division of Infectious Diseases and Immunology at the University of Massachusetts Medical School in Worcester, USA
2005 - 2006
Group leader ‘Therapeutic Oligonucleotides’ in the Division of Clinical Pharmacology, LMU, Munich, Germany
2003 - 2006
Research fellow / Postdoctoral research fellow in the laboratory of Prof. Dr. Gunther Hartmann in the Division of Clinical Pharmacology at the University, Hospital Munich, LMU Germany
Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V. 2013. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503: 530-534.
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V. 2013. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498: 380-384.
Bartok E, Bauernfeind F, Khaminets MG, Jakobs C, Monks B, Fitzgerald KA, Latz E, Hornung V. 2013. iGLuc: a luciferase-based inflammasome and protease activity reporter. Nat Methods 10: 147-154.
Schmid-Burgk JL, Schmidt T, Kaiser V, Honing K, Hornung V. 2013. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes. Nat Biotechnol 31: 76-81.
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V*, Latz E*. 2010. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464: 1357-1361. * equal contributors
Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA*, Hornung V*. 2009. RIG-I- dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III- transcribed RNA intermediate. Nat Immunol 10: 1065-1072. * equal contributors
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. 2009. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458: 514-518.
Hornung V*, Bauernfeind F*, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9: 847-856. * equal contributors
Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G. 2006. 5'-Triphosphate RNA is the ligand for RIG-I. Science 314: 994-997.
Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G. 2005. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11: 263-270.
Address
Gene Center and Department of Biochemistry
Ludwig-Maximilians-University Munich (LMU)
Feodor-Lynen-Str. 25
81377 Munich
eMail
hornung@genzentrum.lmu.de