Scientific Vita

Prof. Dr.

Bertram Bengsch

Academic Education and University Degrees
Ph.D. thesis, Immunology, Department of Medicine II, University Hospital Freiburg, Germany,
2002 - 2008
Study of Medicine at Freiburg University, Germany

Starting 2020
Heisenberg Professorship (Deutsche Forschungsgemeinschaft, DFG)
2017 - 2019
EXCEL program for Excellent Clinician Scientists (Faculty of Medicine, Freiburg)
2017 -
Group leader / Heisenberg scholar, Dpt. of Medicine II, University Hospital Freiburg, Germany
2014 - 2017
Postdoctorate, Institute for Immunology, University of Pennsylvania, USA
2009 - 2014
Clinical and research fellow, Department of Medicine II, University Hospital Freiburg
Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ. 2018. Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity. 48(5):1029-1045.e5.
Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas K, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D’Andrea K, Gimotty PA, Buckley M, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ. 2017. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 545(7652):60-65.
Bengsch B, Ohtani T, Herati RS, Bovenschen N, Chang KM, Wherry EJ. 2017. Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. J Immunol Methods. pii: S0022-1759(17)30132-1.
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. 2016. Bioenergetic insufficiencies due to metabolic alterations are an early driver of CD8 T cell exhaustion. Immunity. 45(2):358-73.
Pauken KE, Sammons MA, Odorizzi PM, Manne SK, Godec J, Khan O, Drake AM, Chen Z, Sen D, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ. 2016. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 354(6316):1160-1165.
Globig AM, Hennecke N, Martin B, Seidl M, Ruf G, Hasselblatt P, Thimme R, Bengsch B. 2014. Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease. Inflamm Bowel Dis. 20(12):2321-9.
Bengsch B*, Martin B*, Thimme R. 2014. Restoration of HBV-specific CD8+ T-cell function by PD-1 blockade in inactive carrier patients is linked to T-cell differentiation. J Hepatol. 61(6):1212-9.
Bengsch B*, Seigel B*, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. 2010. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 6:e1000947.
Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R. 2013. Factors That Determine the Antiviral Efficacy of HCV-Specific CD8(+) T Cells Ex Vivo. Gastroenterology. 144(2):426-36.
Bengsch B*, Jo J*, Seigel B*, Rau SJ*, Schmidt J, Bisse E, Aichele P, Aichele U, Joeckel L, Royer C, Ferreira KS, Borner C, Baumert TF, Blum HE, Lohmann V, Fischer R, Thimme R. 2012. Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential. J Hepatol. 57(1):9-16.
(*equal contribution)
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg