Scientific Vita
Publi­cations
Con­tact

Prof. Dr. Dr.

Bertram Bengsch

Academic Education and University Degrees
2013
Ph.D. thesis, Immunology, Department of Medicine II, University Hospital Freiburg, Germany,
2002 - 2008
Study of Medicine at Freiburg University, Germany

Employment
2020 - today
Heisenberg Professorship (Deutsche Forschungsgemeinschaft, DFG)
since 2020
Attending Physician, Clinic for Internal Medicine II, University Hospital Freiburg
2017 - 2019
EXCEL program for Excellent Clinician Scientists (Faculty of Medicine, Freiburg)
2017 -
Group leader / Heisenberg scholar, Dpt. of Medicine II, University Hospital Freiburg, Germany
2014 - 2017
Postdoctorate, Institute for Immunology, University of Pennsylvania, USA
2009 - 2014
Clinical and research fellow, Department of Medicine II, University Hospital Freiburg
Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. (2010) Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 6:e1000947. doi: 10.1371/journal.ppat.1000947.
2. Bengsch B, Martin B, Thimme R. (2014) Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation. J Hepatol 61:1212-1219. doi: 10.1016/j.jhep.2014.07.005.
3. Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. (2016) Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion. Immunity. 45: 358-373. doi: 10.1016/j.immuni.2016.07.008
4. Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ. (2018) Epigenomic-guided mass cytometry profiling reveals disease-specific features of exhausted CD8 T cells. Immunity. 48:1029-1045e1025. doi: 10.1016/j.immuni.2018.04.026.
5. Schulien I*, Kemming J*, Oberhardt V*, Wild K*, Seidel LM*, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T*, Bengsch B*, Thimme R*, Hofmann M*, Neumann-Haefelin C*. (2021) Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells. Nat Med. 27:78-85. doi: 10.1038/s41591-020-01143-2.
6. Schwabenland M*, Salie H*, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Puschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M*, Bengsch B*. (2021) Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity 54:1594-1610 e1511. doi: 10.1016/j.immuni.2021.06.002.
7. Barsch M, Salie H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger,D, Binder H, Wherry EJ, Schultheiss M, Thimme R, Bengsch B. (2022). T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. J Hepatol. 77: 397-409. doi: 10.1016/j.jhep.2022.02.032.
8. Boettler T*, Csernalabics B*, Salie H, Luxenburger H, Wischer L, Salimi Alizei E, Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M*, Bengsch B*. (2022) SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis. J Hepatol. 77:653-659. doi: 10.1016/j.jhep.2022.03.040.
9. Globig AM*, Hipp AV*, Otto-Mora P, Heeg M, Mayer LS, Ehl S, Schwacha H, Bewtra M, Tomov V, Thimme R, Hasselblatt P, Bengsch B. (2022) High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature. Nat Commun. 13:3688. doi: 10.1038/s41467-022-31229-z.
10. Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp AV, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B. (2022) Exhaustion of CD39-expressing CD8(+) T cells in Crohn's Disease is linked to clinical outcome. Gastroenterology 163:965-981 e931. doi: 10.1053/j.gastro.2022.06.045.
Address
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg
eMail
bertram.bengsch@uniklinik-freiburg.de