Scientific Vita


Katrin Böttcher

Academic Education and University Degrees
04/2018 until now
Physician Scientist and junior research group leader Klinikum rechts der Isar der TU München, Department for Gastroenterology, Munich, Germany
2015 -2018
Honorary Clinical Fellow in Hepatology, Royal Free NHS Foundation Trust, London, UK
2014- 03/2017
PhD student at University College London, Division of Medicine, Institute for Liver and Digestive Health Title: “Investigating immunological and metabolic pathways involved in the pathogenesis of chronic liver disease” Advisor: Prof. Massimo Pinzani, MD, PhD, FRCP
MD University of Bonn Grade: summa cum laude (with highest honour) Title: “Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance” Advisor: Prof. Dr. Percy A. Knolle
License to practice medicine
State examination in Medicine at University of Bonn grade 1.5 (1.0 max. - 6.0 min)
Medical studies at University of Bonn, Prague and London
German Allgemeine Hochschulreife
1. Deschler S, Kager J, Erber J, Fricke L, Koyumdzhieva P, Georgieva A, Lahmer T, Wiessner JR, Voit F, Schneider J, Horstmann J, Iakoubov R, Treiber M, Winter C, Ruland J, Busch DH, Knolle PA, Protzer U, Spinner CD, Schmid RM, Quante M and Böttcher K. Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients. Viruses 2021. 13(2): 241
2. Böttcher K, Longato L, Marrone G, Mazza G, Ghemtio L, Hall A, Luong TV, Caruso S, Viollet B, Zucman-Rossi J, Pinzani M and Rombouts K. AICAR and Compound C negatively modulate HCCinduced primary human hepatic stellate cell activation in vitro. American Journal of Physiology Gastrointestinal and Liver Physiology 2021.
3. Huber W, Lorenz G, Heilmaier M, Böttcher K, Sahm P, Middelhoff M, Ritzer B, Schulz D, Bekka E, Hesse F, Poszler A, Geisler F, Spinner CD, Schmid RM and Lahmer T. Extracorporeal multiorgan support including CO2-removal with the ADVanced Organ Support (ADVOS) system for COVID-19: A case report. The International Journal of Artificial Organs 2020. DOI: 10.1177/0391398820961781
4. Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A, Maralli M, Longato L, Thanapirom K, Vilia MG, Lombardi B, Crowley C, Crawford M, Karsdal MA, Leeming DJ, Marrone G, Bottcher K, et al. Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-b1 Epithelial Mesenchymal Transition. Cells 2019 .10.3390/cells9010083.
5. Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong T, et al. MAIT cells are chronically activated in patients with autoimmune liver disease and promote pro-fibrogenic hepatic stellate cell activation. Hepatology 2018. 68(1):172-186
6. Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, et al. Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut 2018;67:1517-1524.
7. Marrone G, De Chiara F, Böttcher K, Levi A, Dhar D, Longato L, Mazza G, et al. The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells. Hepatology 2018; 68(3):1140-1153
8. Böttcher K, Pinzani M. Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents. Adv Drug Deliv Rev 2017;121:3-8.
9. Singh HD, Otano I, Rombouts K, Singh KP, Peppa D, Gill US, Böttcher K, et al. TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis. Sci Rep 2017;7:5514.
10. Schölzel K, Schildberg FA, Welz M, Börner C, Geiger S, Kurts C, Heikenwälder M, et al. Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol 2014;61:600-608.
Technical University of Munich
TUM School of Medicine
Klinikum rechts der Isar
Klinik und Poliklinik für Innere Medizin II
Ismaninger Str. 22, 81675 Munich
+49 89 4140-9328