Scientific Vita


Alessia Ruggieri

Academic Education and University Degrees

1999 - 2003
PhD thesis in Virology, Ecole Normale Supérieure de Lyon, France supervised by Dr. Francois-Loic Cosset
1998 - 1999
Diploma thesis, University of Lyon, France supervised by Dr. Francois-Loic Cosset
1995 - 1998
Studies in Cellular, Molecular Biology and Virology Metz and Lyon, France


Since 11/2013
Group Leader in the Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Germany
2008 - 2013
Postdoctoral in the lab of Prof. Ralf Bartenschlager, University of Heidelberg, Germany
2004 - 2008
Postdoctoral in the lab of Dr. Jens Mayer, at the Institute of Human Genetics, University of Saarland, Germany
Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A*, Bartenschlager R*. 2015. Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. J Hepatol 63:829-37 * co-corresponding author
deChassey B, Aublin A, Ruggieri A, Pradezynski F, Davoust-Nataf N, Chantier T, Meyniel L, Tafforeau L, Mangeot P, Ciancia C, Navratil V, Rabourdin-Combe C, Bartenschlager R, André P, Lotteau V. 2013. The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication. PLoS Pathog. 9:e1003440
Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V. 2013. The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A. PLoS Pathog. 9:e1003359
Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R. 2012. Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 12:71-85.
Bauhofer O, Ruggieri A, Schmid B, Schirmacher P, Bartenschlager R. 2012. Persistance of HCV in Quiescent Hepatic Cells during an Interferon-Induced Antiviral Response. Gastroenterology 143:429-438
Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R. 2012. Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology 56:2082-93
Ruggieri A, Maldener E, Sauter M, Mueller-Lantzsch N, Meese E, Fackler OT, Mayer J. 2009. Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec. Retrovirology 16:6-17
Flockerzi A, Ruggieri A, Frank O, Medstrand P, Kopper B, Wullich B, Seifarth W, Leib-Mösch C, Meese E, Mayer J. 2008. Expression Pattern of transcribed human endogenous HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project. BMC Genomics 9: 354
Flockerzi A, Maydt J, Frank O, Ruggieri A, Maldener E, Seifarth W, Medstrand P, Lengauer T, Meyerhans A, Leib-Mosch C, Meese E. Mayer J. 2007. Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination. Retrovirology 4: 39-50
Ruggieri A*, Cheynet V*, Oriol G, Blond JL, Boson B, Vachot L, Verrier B, Cosset FL, Mallet F. 2005. Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope. J Virol 79:5585-93 *equal contributions
Department of Infectious Diseases
Molecular Virology Medical Faculty
Heidelberg University
Im Neuenheimer Feld 344
69120 Heidelberg