Scientific Vita
Publi­cations
Con­tact

PD Dr.

Tobias Böttler

Academic Education and University Degrees
2018
Habilitation in Internal Medicine, University of Freiburg (mentor: Prof. Dr. Robert Thimme)2003 - 2007
2000 - 2007
Medical School at Freiburg University, Germany

Employment
Since 2017
Attending physician at the Department of Gastroenterology and Hepatology, Freiburg University (Director: Prof. Dr. Robert Thimme)
Since 2014
Independent group leader at the Department of Gastroenterology and Hepatology, Freiburg University , Germany
Since 2012
Resident physician at the Department of Gastroenterology and Hepatology, Freiburg University, Germany headed by Prof. Dr. H. Blum/ Prof. Dr. Robert Thimme
2009 - 2012
Postdoctoral research at the La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA, supervised by Prof. Dr. Matthias von Herrath
2007 - 2009
Resident physician at the Department of Gastroenterology and Hepatology, Freiburg University, Germany headed by Prof. Dr. H. Blum
Smits M, Zoldan K, Ishaque N, Gu Z, Jechow K, Wieland D, Conrad C, Eils R, Fauvelle C, Baumert TF, Emmerich F, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Boettler T. 2019. Follicular T helper cells shape the HCV-specific CD4 T cell repertoire after viral elimination. J Clin Invest. [Epub ahead of print]
Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, Flecken T, Lang J, Ehrenmann P, Emmerich F, Hofmann M, Thimme R, Neumann-Haefelin C, Boettler T. 2019. OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection. J Hepatol. 70(6):1103-1113.
Adam L, Zoldan K, Hofmann M, Schultheiss M, Bettinger D, Neumann-Haefelin C, Thimme R, Boettler T. 2018. Follicular T Helper Cell Signatures in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis. Hepatol Commun. 2:1051-1063.
Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. 2016. Virus-Specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-Helper Cells in Patients With Acute and Chronic HCV Infections. Gastroenterology. 150:696-706.
Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M. 2013. Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. J Immunol. 191:5026-35.
Boettler T, Pagni PP, Jaffe R, Cheng Y, Zerhouni P, von Herrath M. 2013. The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. J Autoimmun. 44:40-8.
Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG. 2012. OX40 facilitates control of a persistent virus infection. PLoS Pathog. 8:e1002913.
Boettler T, Cheng Y, Ehrhardt K, von Herrath M. 2012. TGF-β blockade does not improve control of an established persistent viral infection. Viral Immunol. 25:232-8.
Boettler T, Panther E, Bengsch B, Nazarova N, Spangenberg HC, Blum HE, Thimme R. 2006. Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J Virol. 80:3532-40.
Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsäcker F, Thimme R. 2005. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol. 79:7860-7.
Address
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg
eMail
tobias.boettler@uniklinik-freiburg.de