Scientific Vita


Tobias Böttler

Academic Education and University Degrees

2003 - 2007
Medical Dissertation, Immunology, Department of Gastroenterology and Hepatology, Freiburg, Germany (Grade: summa cum laude) headed by Prof. Dr. H. Blum, supervised by Prof. Dr. Robert Thimme
2000 - 2007
Medical School at Freiburg University, Germany


Since 2014
Independent group leader at the Department of Gastroenterology and Hepatology, Freiburg University , Germany
Since 2012
Resident physician at the Department of Gastroenterology and Hepatology, Freiburg University, Germany headed by Prof. Dr. H. Blum/ Prof. Dr. Robert Thimme
2009 - 2012
Postdoctoral research at the La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA, supervised by Prof. Dr. Matthias von Herrath
2007 - 2009
Resident physician at the Department of Gastroenterology and Hepatology, Freiburg University, Germany headed by Prof. Dr. H. Blum
Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. 2015. Follicular T helper cell signatures on virus-specific CD4 T cells during acute and chronic HCV-infection. Gastroenterology, accepted
Boettler T, Moradpour D, Thimme R, Zoulim F. 2014. Bridging basic science and clinical research - the EASL Monothematic Conference on Translational Research in Viral Hepatitis. J Hepatol. 61:696-705. Review
Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M. 2013. Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. J Immunol. 191:5026-35.
Boettler T, Pagni PP, Jaffe R, Cheng Y, Zerhouni P, von Herrath M. 2013. The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. J Autoimmun 44:40-8.
Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG. 2012. OX40 facilitates control of a persistent virus infection. PLoS Pathog 8:e1002913.
Boettler T, von Herrath M. 2012. IL-7 receptor α blockade, an off-switch for autoreactive T cells. Proc Natl Acad Sci U S A 109:12270-1
Boettler T, Cheng Y, Ehrhardt K, von Herrath M. 2012. TGF-β blockade does not improve control of an established persistent viral infection. Viral Immunol 25:232-8.
Thimme R, Neagu M, Boettler T, Neumann-Haefelin C, Kersting N, Geissler M, Makowiec F, Obermaier R, Hopt UT, Blum HE, Spangenberg HC. 2008. Comprehensive analysis of the alpha- fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma. Hepatology 48:1821-33.
Boettler T, Panther E, Bengsch B, Nazarova N, Spangenberg HC, Blum HE, Thimme R. 2006. Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J Virol 80:3532-40.
Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsäcker F, Thimme R. 2005. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 79:7860-7.
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg