Scientific Vita

Prof. Dr.

Michael Nassal

Academic Education and University Degrees

Habilitation in Molecular Biology/Virology, Heidelberg University, Germany, Biological Faculty,
1977 - 1980
Ph.D. work, Biological Chemistry, MPI for Medical Research and Heidelberg University, Germany, Chemical Faculty (Grade: summa cum laude) supervised by Prof. Dr. Theo Wieland
1975 - 1977
Diploma work, Peptide Chemistry, MPI for Medical Research and Heidelberg University, Chemical Faculty (grade: very good) supervised by Prof. Dr. Christian Birr,
1970 - 1977
Study of Chemistry at Heidelberg University, Germany


Since 05/1997
Full Professor (C3) for Medical Molecular Biology, University of Freiburg, Germany, Medical Faculty
1989 - 1997
University Assistant (C1, C2) Microbiology, Heidelberg University & ZMBH, Heidelberg, Germany, Project Group Leader
1986 - 1989
Research Assistant, Center for Molecular Biology Heidelberg / ZMBH, Germany (with Heinz Schaller)
1983 - 1986
Postdoc (EMBO fellow), M.I.T., Cambridge, USA (with HG Khorana)
1980 - 1983
Research Assistant, MPI for Medical Research Heidelberg, Germany (with Th. Wieland)
Königer C, Wingert I, Marsmann M, Rösler C, Beck J, Nassal M. Involvement of the host DNA- repair enzyme TDP2 in formation of the covalently closed circular DNA persistance reservoir of hepatitis B viruses. Proc Natl Acad Sci U S A 111:E4244-53
Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, Sültmann H, Urban S. 2014. Hepatitis B and D viruses exploit sodium taurocholate co- transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 146:1070-83
Köck J, Rösler C, Zhang JJ, Blum HE, Nassal M§, Thoma C§. 2010. Generation of covalently closed circular DNA of Hepatitis B viruses via intracellular recycling is regulated in a virus specific manner. PLoS Pathog. 6:e1001082; §shared senior authorship
Sun D, Rösler C, Kidd-Ljunggren K, Nassal M. 2010. Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites. J Hepatol 52:817-26
Dallmeier K, Schultz U, Nassal M. 2008. Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytes. PLoS Pathog 4:e1000230
Beck J, Nassal M. 2007. Hepatitis B virus replication. World J Gastroenterol. 13:48-64. Review. (ranks #10 of all articles in total downloads [6058] from the journal site)
Stahl M, Retzlaff M, Nassal M, Beck J. 2007. Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system. Nucleic Acids Res 35: 6124-6136
Sun D, Nassal M. 2006. Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus. J Hepatol 45:636-45
Nassal M, Rieger A. 1996. A Bulged Region of the Hepatitis B Virus RNA Encapsidation Signal Contains the Replication Origin for Discontinuous First Strand DNA Synthesis. J Virol 70: 2764-2773
Nassal M, Junker-Niepmann M, Schaller H. 1990. Translational Inactivation of RNA Function: Discrimination against a Subset of Genomic Transcripts during HBV Nucleocapsid Assembly. Cell 63: 1357-1363
Department of Medicine II,
Molecular Biology University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg