Scientific Vita

Prof. Dr.

Ursula Klingmüller

Academic Education and University Degrees

Venia Legendi in Cell Biology, University of Heidelberg, Germany
Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg, Germany
Graduate Studies at the University of Heidelberg, Doctoral Thesis, (grade: summa cum laude) supervised by Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg (ZMBH), Germany,
Diploma in Molecular Biology, Cell Biology and Virology, University of Heidelberg, Germany, Diploma Thesis, supervised by Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg (ZMBH), Germany, (with distinction)
Bachelor of Science, University of Bayreuth, Germany (with distinction, November 1985)
High School Diploma, Bayreuth, Germany


Since 2011
W3 Professor, Heidelberg University, Germany
Since 2007
Head of the Division “Systems Biology of Signal Transduction”, German Cancer Research Center (DKFZ), Heidelberg, Germany
2003 - 2007
Group Leader of the Theodor Boveri-Group "Systems Biology of Signal Transduction", German Cancer Research Center (DKFZ), Heidelberg, Germany
1996 - 2003
Group Leader of an independent junior group, Hans-Spemann-Laboratories, Max-Planck-Institute Freiburg, Germany
1993 - 1996
Postdoctoral Fellow, Whitehead Institute for Biomedical Research, Group of Prof. Dr. Harvey F. Lodish, Cambridge, USA
1992 -1993
Postdoctoral Fellow, Harvard Medical School, Group of Prof. Dr. Lewis C. Cantley, Boston, USA
D’Alessandro LA, Samaga R, Maiwald T, Rho SH, Bonefas S, Raue A, Iwamoto N, Kienast A, Waldow K, Meyer R, Schilling M, Timmer J, Klamt S, Klingmüller U. 2015. Disentangling the complexity of HGF signaling in combining qualitative and quantitative modeling. PLoS Comput Biol 11:e1004192.
Mueller S, Huard J, Waldow K, Huang X, D’Alessandro LA, Bohl S, Börner K, Grimm D, Klamt S, Klingmüller U, Schilling M. 2015. T160-phosphorylated CDK2 defines threshold for HGF- dependent proliferation in primary hepatocytes. Mol Sys Biol 11:795.
Raue A, Schilling M, Bachmann J, Matteson M, Schelker M, Kaschek D, Hug S, Kreutz C, Harms BD, Theis FJ, Klingmüller U, Timmer J. 2013. Lessons learned from quantitative dynamical modeling in systems biology. PLoS One 8:e74335.
Hahn B, D'Alessandro LA, Depner S, Waldow K, Boehm ME, Bachmann J, Schilling M, Klingmüller U, Lehmann WD. 2013. Cellular ERK phospho-form profiles with conserved preference for a switch-like pattern. J. Proteome Res 12:637-646.
Bachmann J, Raue A, Schilling M, Boehm ME, Kreutz C, Kaschek, D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U. 2011. Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Sys Biol 7:516.
Becker V, Schilling M, Bachmann J, Baumann U, Raue A, Maiwald T, Timmer J, Klingmüller U. 2010. Covering a Broad Dynamic Range – Information Processing at the Erythropoietin Receptor. Science 328:1404-1408.
Maiwald T, Schneider A, Busch H, Sahl S, Gretz N, Weiss TS, Kummer U, Klingmüller U. 2010. Combining theoretical analysis and experimental data generation reveals IRF9 as crucial factor for accelerating interferon a induced early anti-viral signalling. FEBS J 277:4741-54.
Schilling M, Maiwald T, Hengl S, Winter D, Kolch W, Lehmann WD, Timmer J, Klingmüller U. 2009. Combined Theoretical and Experimental Analysis Links Isoform-specific MAP-kinase Signaling to Cellular Decisions. Mo. Sys Biol 5:334.
Urban S, Breiner KM, Fehler F, Klingmüller U, Schaller H. 1998. Avian Hepatitis B Virus infection is initiated by the interaction of a distinct Pre-S subdomain with the cellular receptor. J Virol 72:8089-8097.
Klingmüller U, Schaller H. 1993. Hepadnavirus infection requires interaction between the viral PreS domain and a specific hepatocellular receptor. J Virol 67:7414-7422.
Division of Systems Biology of Signal Transduction
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg