Scientific Vita

Dr. Dr.

Bertram Bengsch

Academic Education and University Degrees

Ph.D. thesis, Immunology, Department of Medicine II, University Hospital Freiburg, Germany,
2002 - 2008
Study of Medicine at Freiburg University, Germany


2017 -
Group leader / Heisenberg scholar, Dpt. of Medicine II, University Hospital Freiburg, Germany
2014 - 2017
Postdoctorate, Institute for Immunology, University of Pennsylvania, USA
2009 - 2014
Clinical and research fellow, Department of Medicine II, University Hospital Freiburg
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. Bioenergetic insufficiencies due to metabolic alterations are an early driver of CD8 T cell exhaustion. Immunity. 2016;45(2):358-73.
Bengsch B, Martin B, Thimme R. Restoration of HBV-specific CD8+ T-cell function by PD-1 blockade in inactive carrier patients is linked to T-cell differentiation. J Hepatol. 2014;61(6):1212-9
Bengsch B*, Seigel B*, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 2010;6:e1000947.
Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R. Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo. Gastroenterology. 2013;144(2):426-36.
Bengsch B*, Jo J*, Seigel B*, Rau SJ*, Schmidt J, Bisse E, Aichele P, Aichele U, Joeckel L, Royer C, Ferreira KS, Borner C, Baumert TF, Blum HE, Lohmann V, Fischer R, Thimme R. Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential. J Hepatol 2012;57(1):9-16
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg