Scientific Vita
Publi­cations
Con­tact

Dr.

Anna Kosinska

Academic Education and University Degrees
Aug. 2011 – present
Postdoctoral Scientist
Oct. 2007 - Jul. 2011
PhD in Viral immunology
Oct. 2002 - Jun. 2007
Master of Science
Employment
Sept. 2014 – present
Institute of Virology, Technische Universität / Helmholtz Zentrum München, Munich, Germany
1. Su J, Brunner L, Ates-Öz EA, Sacherl J, Frank G, Kerth AK, Thiele F, Wiegand M, Mogler C, Aguilar JC, Knolle PA, Collin N, Kosinska AD*, Protzer U*. Activation of CD4 T cells determines the success of therapeutic hepatitis B vaccination in HBV-carrier mouse models. J Hepatol. 2022 (officially accepted). (*authors contributed equally)

2. Sacherl J*, Kosinska AD*, Kemter K, Kächele M, Laumen SC, Kerth HA, Ates-Öz E, Wolff LS, Su J, Essbauer S, Sutter G, Scholz M, Singethan K, Altrichter J, Protzer U. A thermostable therapeutic vaccine is able to break immune tolerance in a mouse model of chronic hepatitis B. JHEP Reports 2022. doi: https://doi.org/10.1016/j.jhepr.2022.100603. (*authors contributed equally)
3. Kosinska AD, Festag J, Mück-Häusl M, Festag MM, Asen T, Protzer U. Immunogenicity and Antiviral Response of Therapeutic Hepatitis B Vaccination in a Mouse Model of HBeAg-Negative Persistent HBV Infection. Vaccines. 2021 Jul 31;9(8):841. doi: 10.3390/vaccines9080841. PMID: 34451966.
4. Michler T*, Kosinska AD*, Festag J, Bunse T, Su J, Ringelhan M, Imhof H, Grimm D, Steiger K, Mogler C, Heikenwalder M, Michel ML, Guzman CA, Milstein S, Sepp-Lorenzino L, Knolle P, Protzer U. Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice. Gastroenterology. 2020 May;158(6):1762-1775. doi: 10.1053/j.gastro.2020.01.032. PMID: 32001321. (*authors contributed equally)
5. Kosinska AD, Moeed A, Kallin N, Festag J, Su J, Steiger K, Michel ML, Protzer U, Knolle PA. Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection. Sci Rep. 2019 Jul 25;9(1):10808. doi: 10.1038/s41598-019-47149-w. PMID: 31346211.
6. Kosinska AD, Pishraft-Sabet L, Wu W, Fang Z, Lenart M, Chen J, Dietze KK, Wang C, Kemper T, Lin Y, Yeh SH, Liu J, Dittmer U, Yuan Z, Roggendorf M, Lu M. Low hepatitis B virus-specific T-cell response in males correlates with high regulatory T-cell numbers in murine models. Hepatology. 2017 Jul;66(1):69-83. doi: 10.1002/hep.29155. PMID: 28295453.
7. Kosinska AD, Zhang E, Johrden L, Liu J, Seiz PL, Zhang X, Ma Z, Kemper T, Fiedler M, Glebe D, Wildner O, Dittmer U, Lu M, Roggendorf M. Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model. PLoS Pathog. 2013 9(6):e1003391. doi: 10.1371/journal.ppat.1003391. PMID: 23785279.
8. Kosinska AD, Johrden L, Zhang E, Fiedler M, Mayer A, Wildner O, Lu M, Roggendorf M. DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model. J Virol. 2012 Sep;86(17):9297-310. doi: 10.1128/JVI.00506-12. PMID: 22718818.
Address
Institute of Virology
Technische Universität München / Helmholtz Zentrum München Trogerstraße 30, 81675 Munich, Germany
Phone
+49-89-4140-7359
eMail
anna.kosinska@helmholtz-muenchen.de