Project Description

TP13: Dynamics of antiviral T cell immunity against viral infection of the liver

Infections of the liver by hepatotropic viruses are controlled by the adaptive immune system. The dynamics of the antiviral CD8+ T cell immune response leading either to viral clearance or to persistent infection are incompletely defined. Using innovative imaging technologies, in vivo bioluminescence imaging and multispectral optoacoustic imaging, we will determine the dynamics of CD8+ T cell priming, migration and effector function during viral hepatitis. The results will identify key determinants for protective antiviral immunity against hepatotropic infections.
Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. 2017. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 31(6):771-789.e6. doi: 1016/j.ccell.2017.05.006.
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Schölzel K, Schildberg FA, Welz M, Börner C, Geiger S, Kurts C, Heikenwalder M, Knolle PA, Wohlleber D. 2014. Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol 61:600-608
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Stabenow D*, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrant K, Protzer U, Knolle PA. 2010. Bioluminescence imaging allows measuring CD8+ T cell function in the liver. Hepatology 51: 1430-1437; *changed to Wohlleber after marriage.