Latest Publications



2017

Lempp FA, Urban S. 2017. Hepatitis Delta Virus: Replication Strategy and Upcoming Therapeutic Options for a Neglected Human Pathogen. Viruses. 9(7). pii: E172. doi: 10.3390/v9070172. Review. (TP15)

Nassal M. 2017. Chronic hepatitis B: divide and conquer? Gut. 2017 Jul 13. pii: gutjnl-2017-314255. doi: 10.1136/gutjnl-2017-314255. (Epub ahead of print) (TP16)

Levander S, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, Bartenschlager R, Sällberg M. Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model. Gut. 2017 Jun 23. pii: gutjnl-2016-313579. doi: 10.1136/gutjnl-2016-313579. (Epub ahead of print). (TP09)

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017 Jun 12;31(6):771-789.e6. (TP05. TP06. TP13)

Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M. 2017. Phosphorylation of serine 225 in hepatitis C virus NS5A regulates protein-protein interactions. J Virol. 2017 Jun 14. pii: JVI.00805-17. doi: 10.1128/JVI.00805-17. (Epub ahead of print) (TP11)

Schreiner S, Nassal M. 2017. A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond? Viruses. 9(5). pii: E125. doi: 10.3390/v9050125. Review. (TP16)

Protzer U. 2017. Viral hepatitis: The bumpy road to animal models for HBV infection. Nat Rev Gastroenterol Hepatol. 14(6):327-328. Review (TP14, TP18)

Pollmann J, Rölle A, Hofmann M, Cerwenka A. 2017. Hepatitis C Virus and Human Cytomegalovirus-Natural Killer Cell Subsets in Persistent Viral Infections. Front Immunol. 8:566. Review (TP01, TP07)

Tu T, Bühler S, Bartenschlager R. Chronic viral hepatitis and its association with liver cancer. Biol Chem. 2017 Apr 29. pii: /j/bchm.just-accepted/hsz-2017-0118/hsz-2017-0118.xml. doi: 10.1515/hsz-2017-0118. (TP09)

Ko C, Michler T, Protzer U. Novel viral and host targets to cure hepatitis B. Curr Opin Virol. 2017 Apr 20;24:38-45. Review. (TP14)

Tu T, Budzinska MA, Shackel NA, Urban S. 2017. HBV DNA Integration: Molecular Mechanisms and Clinical Implications. Viruses. 9(4). pii: E75. doi: 10.3390/v9040075. Review. (TP15)

Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S. Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Hepatology. 2017 Feb 13. doi: 10.1002/hep.29112. (TP15, TP18)

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R. TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050. (TP01, TP02, TP05)

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M. Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Mol Cell. 2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021. (TP09, TP11, TP17)

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A. Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. MBio. 2017 Jan 10;8(1). pii: e02150-16. doi: 10.1128/mBio.02150-16. (TP09, TP12, TP17)

Xia Y, Protzer U. Control of Hepatitis B Virus by Cytokines. Viruses. 2017 Jan 20;9(1). pii: E18. doi: 10.3390/v9010018. Review. (TP14, TP18)


2016

Wohlleber D, Knolle PA. The role of liver sinusoidal cells in local hepatic immune surveillance. Clin Transl Immunology. 2016 Dec 9;5(12):e117. doi: 10.1038/cti.2016.74. Review. (TP05, TP08, TP13)

Protzer U, Knolle P. "To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B. Gastroenterology. 2016 Nov;151(5):805-806. doi: 10.1053/j.gastro.2016.09.038 (TP05, TP08, TP14, TP18)

Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwalder M, Protzer U, Grimm D. Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO Mol Med. 2016 Sep 1;8(9):1082-98. doi: 10.15252/emmm.201506172. (TP06, TP14, TP18)

Hofmann M, Thimme R. MAIT be different-persisting dysfunction after DAA-mediated clearance of chronic hepatitis C virus infection. Eur J Immunol. 2016 Sep;46(9):2099-102. doi: 10.1002/eji.201646581. (TP01)

Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 2017 Jan 9;45(1):e3. doi: 10.1093/nar/gkw805. (TP09, TP18, Z2)