Latest Publications



2019

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A. 2019. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol. 2019 Mar 4. doi: 10.1038/s41590-019-0323-3. (TP11)

Deng L, Jiang W, Wang X, Merz A, Hiet MS, Chen Y, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G. 2019. Syntenin regulates Hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes. J Hepatol. 2019 Mar 14. pii: S0168-8278(19)30147-3. doi:10.1016/j.jhep.2019.03.006. (TP09)

Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, Flecken T, Lang J, Ehrenmann P, Emmerich F, Hofmann M, Thimme R, Neumann-Haefelin C, Boettler T. 2019. OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection. J Hepatol. 2019 Feb 28. pii: S0168-8278(19)30131-X. doi: 10.1016/j.jhep.2019.02.016. (Epub ahead of print). (TP01, TP02, TP04)

Karimzadeh H, Kiraithe MM, Oberhardt V, Alizei ES, Bockmann J, Zur Wiesch JS, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C. 2019. Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level. Gastroenterology. 2019 Feb 12. pii: S0016-5085(19)30366-X. doi: 10.1053/j.gastro.2019.02.003. (Epub ahead of print). (TP01, TP02, TP03, TP14)

Schuch A, Salimi Alizei E, Heim K, Wieland D, Kiraithe MM, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M, Thimme R. 2019. Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut. 2019 Jan 8. pii: gutjnl-2018-316641. doi: 10.1136/gutjnl-2018-316641. (Epub ahead of print). (TP01, TP02, TP15, TP16, A01)

Xia Y, Schlapschy M, Morath V, Roeder N, Vogt EI, Stadler D, Cheng X, Dittmer U, Sutter K, Heikenwalder M, Skerra A, Protzer U. 2019. PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice. Antiviral Res. 161:134-143. doi: 10.1016/j.antiviral.2018.11.003. (TP06, TP14)

Bartenschlager R, Urban S, Protzer U. 2019. Towards curative therapy of chronic viral hepatitis. Z Gastroenterol. 57(1):61-73. doi: 10.1055/a-0824-1576. Review. (TP09, TP14, TP15)

Gehring AJ, Protzer U. 2019. Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection. Gastroenterology. 156(2):325-337. doi: 10.1053/j.gastro.2018.10.032. (TP14)



2018

Bubeck F, Hoffmann MD, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Börner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D. 2018. Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nat Methods. 15(11):924-927. (TP18, Z02)

Velkov S, Ott JJ, Protzer U, Michler T. 2018. The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.
Genes (Basel). 9(10). pii: E495. doi: 10.3390/genes9100495. (TP14)

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. 2018. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 9(1):4805. doi: 10.1038/s41467-018-07213-x. (TP05, TP13)

Luxenburger H, Neumann-Haefelin C, Thimme R, Boettler T. 2018. HCV-Specific T Cell Responses During and After Chronic HCV Infection. Viruses. 10(11). pii: E645. doi: 10.3390/v10110645. Review. (TP01, TP02, TP04)

Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M. 2018. NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection. J Hepatol. 2018 Oct 18. pii: S0168-8278(18)32458-9. doi: 10.1016/j.jhep.2018.10.006. (Epub ahead of print). (TP01. TP02, TP04, TP07)

Lazarus J, Block T, Bréchot C, Kramvis A, Miller V, Ninburg M, Penicaud MC, Protzer U, Razavi H, Thomas L, Wallace J, Cowie B. 2018. The hepatitis B epidemic and the urgent need for cure preparedness. Nature Reviews Gastroenterology and Hepatology. 15(9): 517-518. (TP14)

Lohmann V. 2018. Hepatitis C virus cell culture models: an encomium on basic research paving the road to therapy development. Med Microbiol Immunol. 2018 Oct 8. doi: 10.1007/s00430-018-0566-x. Review. (Epub ahead of print). (TP17)

Rehermann B, Thimme R. 2018. Insights From Antiviral Therapy into Immune Responses to HBV and HCV Infection. Gastroenterology. 2018 Sep 26. pii: S0016-5085(18)35037-6. doi: 10.1053/j.gastro.2018.08.061. (Epub ahead of print). (TP01)

Neumann-Haefelin C, Thimme R. 2018. Entering the spotlight: hepatitis B surface antigen-specific B cells. J Clin Invest. 128(10):4257-4259. Review. (TP01, TP02)

Qu B, Ni Y, Lempp FA, Vondran FWR, Urban S. 2018. T5 exonuclease hydrolysis of Hepatitis B Virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR. J Virol. 2018 Sep 19. pii: JVI.01117-18. doi: 10.1128/JVI.01117-18. (Epub ahead of print) (TP15)

Schmelas C, Grimm D. 2018. Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology. Biotechnol J. 13(9):e1700432. doi: 10.1002/biot.201700432. Review. (TP18)

Herrmann AK, Grimm D. 2018. High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious. J Mol Biol. 430(17):2626-2640. doi: 10.1016/j.jmb.2018.05.022. Review. (TP18)

Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D. 2018. AAVvector-mediated in vivo reprogramming into pluripotency.Nat Commun. 9(1):2651. doi: 10.1038/s41467-018-05059-x. (TP18)

Tu T, Budzinska MA, Vondran FWR, Shackel NA, Urban S. 2018. Hepatitis B virus DNA integration occurs early in the viral life cycle in an in vitro infection model via NTCP-dependent uptake of enveloped virus particles. J Virol. 2018 Feb 7. pii: JVI.02007-17. doi: 10.1128/JVI.02007-17. (Epub ahead of print) (TP15)

Tu T, Urban S. 2018. Virus entry and its inhibition to prevent and treat hepatitis B and hepatitis D virus infections. Curr Opin Virol. 30:68-79. doi: 10.1016/j.coviro.2018.04.004.Review. (TP15)

Budzinska MA, Shackel NA, Urban S, Tu T. 2018. Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion. Emerg Microbes Infect. 7(1):142. doi: 10.1038/s41426-018-0145-7. (TP15)

Budzinska MA, Shackel NA, Urban S, Tu T. 2018. Cellular Genomic Sites of Hepatitis B Virus DNA Integration. Genes (Basel). 9(7). pii: E365. doi: 10.3390/genes9070365. Review. (TP15)

Müncheberg S, Hay TR, Ip HW., Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S. 2018. E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression. J Virol. 92(13).pii: e00164-18. doi: 10.1128/JVI.00164-18. (TP16)

Inturi R., Mun K., Singethan K., Schreiner S, Punga T. 2018. Human Adenovirus Infection Counteracts Antiviral Activity of the celllar MKRN1 E3 Ubiquitin Ligase. J Virol. 17;92(3). pii: e01154-17. doi: 10.1128/JVI.01154-17. (TP16)

Freudenberger N., Hay R. T., Groitl P., Dobner T., Schreiner S, 2018. HAdV pV core protein is targeted by the host SUMOylation machinery to pursue essential viral functions. J Virol. 92(4). pii: e01451-17. doi: 10.1128/JVI.01451-17. (TP16)

Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. 2018. Hepatitis B virus (HBV) genome recycling and de novo secondary infection events maintain stable cccDNA levels. J Hepatol. 2018 Aug 21. pii: S0168-8278(18)32294-3. doi: 10.1016/j.jhep.2018.08.012. (Epub ahead of print) (TP14)

Schiwon M, Ehrke-Schulz E, Oswald A, Bergmann T, Michler T, Protzer U, Ehrhardt A. 2018. One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors. Mol Ther Nucleic Acids. 12:242-253. doi: 10.1016/j.omtn.2018.05.006. (TP18)

Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G, Pichlmair A. 2018. Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity. PLoS Pathog 14(4):e1006980. doi: 10.1371/journal.ppat.1006980. eCollection 2018 Apr. (TP11)

Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A. 2018. An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 Sep 3. doi: 10.1038/s41586-018-0484-5. (Epub ahead of print) (TP09, TP11)

Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T. 2018. microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology. 2018 Aug 27. pii: S0016-5085(18)34918-7. doi: 10.1053/j.gastro.2018.08.032. (Epub ahead of print) (TP6)

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D. 2018. Outcome of anti-viral immunity in the liver is shaped by the level of antigen expressed in infected hepatocytes. Hepatology. 2018 May 5. doi: 10.1002/hep.30080. (TP01, TP14, TP13, TP15; Bengsch associated) (Epub ahead of print)

Nassal M. 2018. Chronic hepatitis B: divide and conquer? Gut. 67(3):400-402. doi: 10.1136/gutjnl-2017-314255. (TP16)

Dembek C, Protzer U, Roggendorf M. 2018. Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination. Curr Opin Virol. 30:58-67. doi: 10.1016/j.coviro.2018.04.003. Review. (TP14)

Esser K, Lucifora J, Wettengel J, Singethan K, Glinzer A, Zerneke A, Protzer U. 2018. Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle. Antiviral
Research 151: 4-7. (TP14)

Hofmann M, Wieland D, Pircher H, Thimme R. 2018. Memory vs memory-like: The different facets of CD8+ T-cell memory in HCV infection.Immunol Rev. 283(1):232-237. doi: 10.1111/imr.12642. (TP01)

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M. 2018. Amino acid substitutions within HLA-B*27-restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8+ T cells. J Virol. 92(13). pii: e01891-17. doi: 10.1128/JVI.01891-17. (TP01, TP02, TP03, TP14)

Provine NM, Binder B, FitzPatrick MEB, Schuch A, Garner LC, Williamson KD, van Wilgenburg B, Thimme R, Klenerman P, Hofmann M. Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells. Front Immunol. 2018 Apr 23;9:756. doi: 10.3389/fimmu.2018.00756. eCollection 2018. (TP01)

Groepper C, Rufinatscha K, Schröder N, Stindt S, Ehlting C, Albrecht U, Bock HH, Bartenschlager R, Häussinger D, Bode JG. 2018. HCV modifies EGF signalling and upregulates production of CXCR2 ligands: role in inflammation and antiviral immune response. J Hepatol. 69(3):594-602. doi: 10.1016/j.jhep.2018.04.005 (TP09)

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V. 2018. Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes. Gastroenterology. 154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020. (TP01, TP02, TP09, TP11, TP17)

Zhang Z, Filzmayer C, Ni Y, Sültmann H, Mutz P, Hiet MS, Vondran FWR, Bartenschlager R, Urban S. 2018. Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes. J Hepatol. 69(1):25-35. doi: 10.1016/j.jhep.2018.02.021 (TP09, TP15)

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M. 2018. Single cell polarity in liquid phase facilitates tumour metastasis. Nat Commun. 9(1):887. doi: 10.1038/s41467-018-03139-6. (TP06, TP14)

Neufeldt CJ, Cortese M, Acosta EG, Bartenschlager R. 2018. Rewiring cellular networks by members of the Flaviviridae family. Nat Rev Microbiol.16(3):125-142. doi: 10.1038/nrmicro.2017.170. (TP09)

Mutz P, Metz P, Lempp FA, Bender S, Qu B, Schöneweis K, Seitz S, Tu T, Restuccia A, Frankish J, Dächert C, Schusser B, Koschny R, Polychronidis G, Schemmer P, Hoffmann K, Baumert TF, Binder M, Urban S, Bartenschlager R. 2018. HBV Bypasses the Innate Immune Response and Does not Protect HCV From Antiviral Activity of Interferon. Gastroenterology. 154(6):1791-1804.e22. doi: 10.1053/j.gastro.2018.01.044. (TP09, TP11, TP15).

Luxenburger H, Graß F, Baermann J, Boettler T, Marget M, Emmerich F, Panning M, Thimme R, Nitschke K, Neumann-Haefelin C. Differential virus-specific CD8(+) T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4. J Viral Hepat. 2018 Feb 3. doi: 10.1111/jvh.12874. (Epub ahead of print) PubMed PMID: 29397015. (TP01, TP02, TP04)

Utzschneider DT, Delpoux A, Wieland D, Huang X, Lai CY, Hofmann M, Thimme R, Hedrick SM. 2018. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep. 22(13):3454-3467. (TP01)

Boettler T, Thimme R. 2018. Lost in Inflammation: The Functional Conversion of Regulatory T Cells in Acute Hepatitis A Virus Infection. Gastroenterology. 154(4):798-800. doi: 10.1053/j.gastro.2018.02.003. (TP01, TP04)

Holze C, Michaudel C, Mackowiak C, Haas D. A, Benda C, Hubel P, Pennemann F. L, Schnepf, D, Wettmarshausen J, Braun M, Leung D.W, Amarasinghe G. K, Perocchi F, Staeheli P, Ryffel B, Pichlmair A. 2018. Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.Nature Immunology V19, pages130–140 doi:10.1038/s41590-017-0013-y (TP11)

Schmelas, C, Grimm D. 2018. Split Cas9, not hairs - advancing the therapeutic index of CRISPR technology.Biotechnol J. 2018 Jan 5. doi: 10.1002/biot.201700432. (Epub ahead of print) (TP18)

Ringelhan M, Pfister D, O'Connor T, Pikarsky E, Heikenwalder M. 2018.
The immunology of hepatocellular carcinoma. Nature Immunology. 19(3):222-232. (TP06)

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A. 2018. Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis. J Hepatol. 68(3):421-430. (TP01, TP07, TP09, TP17)



2017

Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs J, Bartenschlager R. 2017. Deciphering the origin and evolution of hepatitis B viruses by means of a family of nonenveloped fish viruses. Cell Host & Microbe. 22(3):387-399.e6. doi: 10.1016/j.chom.2017.07.019. (TP09)

Klöss V, Grünvogel O, Wabnitz G, Eigenbrod T, Ehrhardt S, Lasitschka F,Lohmann V, Dalpke AH. 2017. Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells. Front Immunol. 8:1238. doi: 10.3389/fimmu.2017.01238. eCollection 2017. (TP17)

Li Y, Xia Y, Han M, Chen G, Zhang D, Thasler W, Protzer U, Ning Q. 2017. IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection. Scientific Reports 7(1):12715. doi: 10.1038/s41598-017-13082-z. (TP14)

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R. 2017. Host-directed therapies for bacterial and viral infections. Nat Rev Drug Discov. 2017 Sep 22. doi: 10.1038/nrd.2017.162

P Lucarelli, M Schilling, C Kreutz, A Vlasov, ME Boehm, N Iwamoto, B Steiert, S Lattermann, M Wäsch, M Stepath, MS Matter, M Heikenwälder, K Hoffmann, D Deharde, G Damm, D Seehofer, M Muciek, N Gretz, WD Lehmann, J Timmer, U Klingmüller. 2017. Resolving the Combinatorial Complexity of Smad Protein Complex Formation and the Link to Gene Expression. Cell Systems, accepted (TP06, TP10).

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U. 2017. Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017. (TP10)

Lempp FA, Urban S. 2017. Hepatitis Delta Virus: Replication Strategy and Upcoming Therapeutic Options for a Neglected Human Pathogen. Viruses. 9(7). pii: E172. doi: 10.3390/v9070172. Review. (TP15)

Nassal M. 2017. Chronic hepatitis B: divide and conquer? Gut. 2017 Jul 13. pii: gutjnl-2017-314255. doi: 10.1136/gutjnl-2017-314255. (Epub ahead of print) (TP16)

Levander S, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, Bartenschlager R, Sällberg M. Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model. Gut. 2017 Jun 23. pii: gutjnl-2016-313579. doi: 10.1136/gutjnl-2016-313579. (Epub ahead of print). (TP09)

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017 Jun 12;31(6):771-789.e6. (TP05. TP06. TP13)

Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M. 2017. Phosphorylation of serine 225 in hepatitis C virus NS5A regulates protein-protein interactions. J Virol. 2017 Jun 14. pii: JVI.00805-17. doi: 10.1128/JVI.00805-17. (Epub ahead of print) (TP11)

Schreiner S, Nassal M. 2017. A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond? Viruses. 9(5). pii: E125. doi: 10.3390/v9050125. Review. (TP16)

Protzer U. 2017. Viral hepatitis: The bumpy road to animal models for HBV infection. Nat Rev Gastroenterol Hepatol. 14(6):327-328. Review (TP14, TP18)

Pollmann J, Rölle A, Hofmann M, Cerwenka A. 2017. Hepatitis C Virus and Human Cytomegalovirus-Natural Killer Cell Subsets in Persistent Viral Infections. Front Immunol. 8:566. Review (TP01, TP07)

Tu T, Bühler S, Bartenschlager R. Chronic viral hepatitis and its association with liver cancer. Biol Chem. 2017 Apr 29. pii: /j/bchm.just-accepted/hsz-2017-0118/hsz-2017-0118.xml. doi: 10.1515/hsz-2017-0118. (TP09)

Ko C, Michler T, Protzer U. Novel viral and host targets to cure hepatitis B. Curr Opin Virol. 2017 Apr 20;24:38-45. Review. (TP14)

Tu T, Budzinska MA, Shackel NA, Urban S. 2017. HBV DNA Integration: Molecular Mechanisms and Clinical Implications. Viruses. 9(4). pii: E75. doi: 10.3390/v9040075. Review. (TP15)

Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S. Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Hepatology. 2017 Feb 13. doi: 10.1002/hep.29112. (TP15, TP18)

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JM, Steinmann E. 2017. Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A. 114(12):E2430-E2439. doi: 10.1073/pnas.1619380114. (TP09)

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R. TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050. (TP01, TP02, TP05)

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M. Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Mol Cell. 2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021. (TP09, TP11, TP17)

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A. Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. MBio. 2017 Jan 10;8(1). pii: e02150-16. doi: 10.1128/mBio.02150-16. (TP09, TP12, TP17)

Golsaz-Shirazi F, Amiri MM, Farid S, Bahadori M, Bohne F, Altstetter S, Wolff L, Kazemi T, Khoshnoodi J, Hojjat-Farsangi M, Chudy M, Jeddi-Tehrani M, Protzer U, Shokri F. 2017. Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg). Antiviral Res. 144:153-163. (TP14)

Xia Y, Protzer U. Control of Hepatitis B Virus by Cytokines. Viruses. 2017 Jan 20;9(1). pii: E18. doi: 10.3390/v9010018. Review. (TP14, TP18)

Burwitz B, Wettengel J, Mück-Häusl M, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Reed N, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U**, Sacha J**. 2017. Hepatocytic Expression of Human Sodium-Taurocholate Cotransporting Polypeptide Enables Hepatitis B Virus Infection of Macaques. Nature Communications 8 (1): 2146. **co-corresponding authors. (TP14)




2016

Wohlleber D, Knolle PA. The role of liver sinusoidal cells in local hepatic immune surveillance. Clin Transl Immunology. 2016 Dec 9;5(12):e117. doi: 10.1038/cti.2016.74. Review. (TP05, TP08, TP13)

Pikarsky E, Heikenwalder M. 2016. Focal and Local: Ectopic Lymphoid Structures and Aggregates of Myeloid and Other Immune Cells in Liver. Gastroenterology. 151(5):780-783. doi: 10.1053/j.gastro.2016.09.029. (TP06)

Protzer U, Knolle P. "To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B. Gastroenterology. 2016 Nov;151(5):805-806. doi: 10.1053/j.gastro.2016.09.038 (TP05, TP08, TP14, TP18)

Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwalder M, Protzer U, Grimm D. Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO Mol Med. 2016 Sep 1;8(9):1082-98. doi: 10.15252/emmm.201506172. (TP06, TP14, TP18)

Hofmann M, Thimme R. MAIT be different-persisting dysfunction after DAA-mediated clearance of chronic hepatitis C virus infection. Eur J Immunol. 2016 Sep;46(9):2099-102. doi: 10.1002/eji.201646581. (TP01)

Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 2017 Jan 9;45(1):e3. doi: 10.1093/nar/gkw805. (TP09, TP18, Z2)