Project Description
Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R. 2015. HBV-infected HepG2hNTCPcells serve as a novel immunological tool to ana- lyse the antiviral efficacy of CD8+ T cells in vitro. J Virol 89:7433-8
Nitschke K, Flecken T, Schmidt J, Gostick E, Marget M, Neumann-Haefelin C, Blum HE, Price DA, Thimme R. 2015. Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus- specific CD8+ T cells in chronic infection. J Virol 89:25-34
Bengsch B, Martin B, Thimme R. 2014. Restoration of HBV-specific CD8+ T cell function by PD-1 block- ade in inactive carrier patients is linked to T cell differentiation. J Hepatol 61:1212-9
Martin B, Hennecke N, Lohmann V, Kayser A, Neumann-Haefelin C, Kukolj G, Böcher WO, Thimme R. 2014. Restoration of HCV-specific CD8+ T cell functions by IFN-free therapy. J Hepatol 61:538-43
Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R. 2013. Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo. Gastroenterology 144:426-36.
Hofmann M, Oschowitzer A, Kurzhals SR, Krüger CC, Pircher H. 2013. Thymus-resident memory CD8+ T cells mediate local immunity. Eur J Immunol 43:2295-304
Hofmann M, Schweier O, Pircher H. 2012. Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations. Eur J Immunol 42:2484-90
Hofmann M, Pircher H. 2011. E-cadherin promotes accumulation of a unique memory CD8 T-cell popula- tion in murine salivary glands. Proc Natl Acad Sci USA 108:16741-6
Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. 2010. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 6:e1000947
Jo J, Aichele U, Kersting N, Klein R, Aichele P, Bisse E, Sewell AK, Blum HE, Bartenschlager R, Loh- mann V, Thimme R. 2009. Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication us- ing a noval immunological model. Gastroenterology 136:1391-401