Scientific Vita
Publi­cations
Con­tact

Dr. Dr.

Katrin Böttcher

Academic Education and University Degrees
04/2018 until now
Physician Scientist and junior research group leader Klinikum rechts der Isar der TU München, Department for Gastroenterology, Munich, Germany
2015 -2018
Honorary Clinical Fellow in Hepatology, Royal Free NHS Foundation Trust, London, UK
2014- 03/2017
PhD student at University College London, Division of Medicine, Institute for Liver and Digestive Health Title: “Investigating immunological and metabolic pathways involved in the pathogenesis of chronic liver disease” Advisor: Prof. Massimo Pinzani, MD, PhD, FRCP
2015
MD University of Bonn Grade: summa cum laude (with highest honour) Title: “Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance” Advisor: Prof. Dr. Percy A. Knolle
11/2013
License to practice medicine
2013
State examination in Medicine at University of Bonn grade 1.5 (1.0 max. - 6.0 min)
2006-2013
Medical studies at University of Bonn, Prague and London
2006
German Allgemeine Hochschulreife
1. Deschler S, Kager J, Erber J, Fricke L, Koyumdzhieva P, Georgieva A, Lahmer T, Wiessner JR, Voit F, Schneider J, Horstmann J, Iakoubov R, Treiber M, Winter C, Ruland J, Busch DH, Knolle PA, Protzer U, Spinner CD, Schmid RM, Quante M, Böttcher K. (2021) Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients. Viruses. 13(2): 241. doi: 10.3390/v13020241.
2. Böttcher K, Longato L, Marrone G, Mazza G, Ghemtio L, Hall A, Luong TV, Caruso S, Viollet B, Zucman-Rossi J, Pinzani M, Rombouts K. (2021) AICAR and Compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro. Am J Physiol Gastrointest Liver Physiol. 320(4):G543-G556. doi.org/10.1152/ajpgi.00262.2020.
3. Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A, Maralli M, Longato L, Thanapirom K, Vilia MG, Lombardi B, Crowley C, Crawford M, Karsdal MA, Leeming DJ, Marrone G, Bottcher K, Robinson B, Del Rio Hernandez A, Tamburrino D, Spoletini G, Malago M, Hall AR, Godovak-Zimmermann J, Luong TV, De Coppi P, Pinzani M, Rombouts K. (2019) Cirrhotic human liver extracellular matrix 3D scaffolds promote smad-dependent TGF-1 epithelial mesenchymal transition. Cells. 9(1):83. doi: 10.3390/cells9010083.
4. Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong T, Tsochatzis EA, Thorburn D, Pinzani M. (2018) MAIT cells are chronically activated in patients with autoimmune liver disease and promote pro-fibrogenic hepatic stellate cell activation. Hepatology. 68(1):172-186. doi: 10.1002/hep.29782.
5. Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Graeme A, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen Bertus, Ellinghaus D, Färkkilla M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Hirschfield GM, van Hoek B, Holm K, Hohenester S, Roksund Hov J, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum E, Milciewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vich Vila A, de Vries B, Zachou K, International PSC Study Group, The UK PSC Consortium, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weermsma RK. (2018) Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut. 67:1517-1524. doi: 10.1136/gutjnl-2016-313598.
6. Marrone G, De Chiara F, Böttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang Z, Marrali M, Fernández-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K. (2018) The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: a key regulator of the profibrogenic phenotype of human hepatic stellate cells. Hepatology. 68(3):1140-1153. doi: 10.1002/hep.30029.
7. Böttcher K, Pinzani M. (2017) Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents. Adv Drug Deliv Rev. 121:3-8. doi: 10.1016/j.addr.2017.05.016.
8. Singh HD, Otano I, Rombouts K, Singh KP, Peppa D, Gill US, Böttcher K, Kennedy PTF, Oben J, Pinzani M, Walczak H, Fusai G, Rosenberg WMC, Maini MK. (2017) TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis. Sci Rep. 7:5514. doi: 10.1038/s41598-017-05845-5.
9. Schölzel K, Schildberg FA, Welz M, Börner C, Geiger S, Kurts C, Heikenwälder M, Knolle PA, Wohlleber D. (2014). Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol 61:600-608. doi: 10.1016/j.jhep.2014.04.028 (related editorial: Carambia A, Herkel J. J Hepatol. Doi: 10.1016/j.jhep.2014.06.003).
Address
Technical University of Munich
TUM School of Medicine
Klinikum rechts der Isar
Klinik und Poliklinik für Innere Medizin II
Ismaninger Str. 22, 81675 Munich
Phone
+49 89 4140-9328
eMail
katrin.boettcher@mri.tum.de