Project Description

TP11: Global effects on host cell signalling by continuous stimulation of innate antiviral responses in persistent viral infections

Virus infection triggers pathogen recognition receptors, which will activate several antiviral effector pathways. This is a dynamic and transient process that typically ceases concomitant with a reduction of the pathogen-derived stimulus, ultimately reestablishing resting-state homeostasis. The situation is different in persistent infections, such as Hepatitis C, B or D virus infection, where permanent presence of viral compounds continuously stimulates antiviral pathways, leading to a perturbed, infected-state homeostasis. With state-of-the-art MS technology, this project will characterize the molecular alterations of the cellular signaling network during infected-state homeostasis, and establish their functional consequences for innate, but also adaptive immune responses to chronic hepatitis viruses.
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Binder M, Kochs G, Bartenschlager R, Lohmann V. 2007. Hepatitis C virus escape from the interferon regulato- ry factor 3 pathway by a passive and active evasion strategy. Hepatology 46: 1365–1374.
Pichlmair A, ..., Reis e Sousa C. 2006. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'- phosphates. Science 314: 997–1001.
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