Latest Publications



2024

Hofmann M, Thimme R, Schamel WW. PD-1 and LAG-3: synergistic fostering of T cell exhaustion. Signal Transduct Target Ther. 2024 Oct 18;9(1):291. (TP01, TP20)

Salié H, Wischer L, D'Alessio A, Godbole I, Suo Y, Otto-Mora P, Beck J, Neumann O, Stenzinger A, Schirmacher P, Fulgenzi CAM, Blaumeiser A, Boerries M, Roehlen N, Schultheiß M, Hofmann M, Thimme R, Pinato DJ, Longerich T, Bengsch B. Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma. Gut. 2024 Oct 14:gutjnl-2024-332837. doi: 10.1136/gutjnl-2024-332837. Epub ahead of print. PMID: 39349005. (TP01, TP20, TP21, Z02)

Heim K, Sagar, Sogukpinar Ö, Llewellyn-Lacey S, Price DA, Emmerich F, Kraft ARM, Cornberg M, Kielbassa S, Knolle P, Wohlleber D, Bengsch B, Boettler T, Neumann-Haefelin C, Thimme R, Hofmann M. Attenuated effector T cells are linked to control of chronic HBV infection. Nat Immunol. 2024 Sep;25(9):1650-1662. doi: 10.1038/s41590-024-01928-4. (TP01, TP02 ,TP04 ,TP05 ,TP13 , TP20, TP21)

Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Fürst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, Öllinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Böttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA. “A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection.” Nature (2024). DOI: https://doi.org/10.1038/s41586-024-07630-7 (TP05, TP14, TP18, TP01, Z02, TP13)

Fiehn F, Beisel C, Binder M. Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals. Curr Opin Virol. 2024 Jun 25;67:101423. doi: 10.1016/j.coviro.2024.101423. Epub ahead of print. (TP11)

Gnouamozi GE, Zhang Z, Prasad V, Lauber C, Seitz S, Urban S. Analysis of Replication, Cell Division-Mediated Spread, and HBV Envelope Protein-Dependent Pseudotyping of Three Mammalian Delta-like Agents. Viruses 2024,16,859. https://doi.org/10.3390/v16060859 (TP15, TP23)

Hofmann S, Luther J, Plank V, Oswald A, Mai J, Simons I, Miller J, Falcone V, Hansen-Palmus L, Hengel H, Nassal M, Protzer U, Schreiner S. Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection. Microbiol Spectr. 2024 Apr 3:e0378823. doi: 10.1128/spectrum.03788-23. Epub ahead of print. (TP14, TP16, TP19)

Gruber C, Krautner L, Bergant V, Grass V, Ma Z, Rheinemann L, Krus A, Reinhardt F, Mazneykova L, Rocha-Hasler M, Truong DJ, Westmeyer GG, Pichlmair A, Ebert G, Giesert F, Wurst W. Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting. Cell Discov. 2024 Apr 12;10(1):42. doi: 10.1038/s41421-024-00672-1. (TP11)

Göttig L, Schreiner S. E4orf1: The triple agent of adenovirus - Unraveling its roles in oncogenesis, infectious obesity and immune responses in virus replication and vector therapy. Tumour Virus Res. 2024 Feb 28;17:200277. doi: 10.1016/j.tvr.2024.200277. Epub ahead of print. (TP16)

Göttig L, Jummer S, Staehler L, Groitl P, Karimi M, Blanchette P, Kosulin K, Branton PE, Schreiner S. The human adenovirus PI3K-Akt activator E4orf1 is targeted by the tumor suppressor p53. J Virol 0:e01701-23. (TP16)

Seitz S, Bartenschlager R. Cutting edges in the hepatitis B virus genome: How RNA splicing is involved in modulating virus ultrastructure to promote infection. J Hepatol. 2024 Mar 7:S0168-8278(24)00148-X. doi: 10.1016/j.jhep.2024.02.029. Epub ahead of print. PMID: 38460792.(TP09, TP23)

Su J, Taji ZH, Kosinska AD, Oz EA, Xie Z, Bielytskyi P, Shein M, Hagen P, Esmaeili S, Steiger K, Protzer U, Schütz AK, Introducing adjuvant-loaded particulate hepatitis B core antigen as an alternative therapeutic hepatitis B vaccine component, JHEP Reports 6.4 (2024): 100997, doi: https://doi.org/10.1016/j.jhepr.2023.100997. (TP14, TP18, TP23)



2023

Groth C, Maric J, Garcés Lázaro I, Hofman T, Zhang Z, Ni Y, Keller F, Seufert I, Hofmann M, Neumann-Haefelin C, Sticht C, Rippe K, Urban S, Cerwenka A. Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity. Front Immunol. 2023 Dec 8;14:1287367. doi: 10.3389/fimmu.2023.1287367. (TP02, TP07, TP15, TP20, Z03)

H. Mohsenin, H. J. Wagner, M. Rosenblatt, S. Kemmer, F. Drepper, P. Huesgen, J. Timmer, W. Weber, Design of a Biohybrid Materials Circuit with Binary Decoder Functionality. Adv. Mater. 2024, 36, 2308092. https://doi.org/10.1002/adma.202308092 (TP10)

Festag J, Festag MM, Asen T, Wettengel JM, Mück-Häusl MA, Abdulhaqq S, Stahl-Hennig C, Sacha JB, Burwitz BJ, Protzer U, Wisskirchen K. Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures. Hum Gene Ther. 2023 Dec;34(23-24):1204-1218. doi: 10.1089/hum.2023.035. (TP14)

Hiebinger F, Kudulyte A, Chi H, Burbano De Lara S, Ilic D, Helm B, Welsch H, Dao Thi VL, Klingmüller U, Binder M. Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression. Cancer Cell Int. 2023 Dec 8;23(1):315. doi: 10.1186/s12935-023-03150-y.(TP10, TP11, TP22)

Wittkop L, Boettler T. More than shots in the dark: driving vaccine efficacy in cirrhosis. Gut. 2023 Dec 7;73(1):8-9. doi: 10.1136/gutjnl-2023-329867. (TP04)

Csernalabics B, Marinescu MS, Maurer L, Kelsch L, Werner J, Baumann K, Zoldan K, Panning M, Reuken P, Bruns T, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Dao Thi VL, Boettler T. Efficient formation and maintenance of humoral and CD4 T cell immunity targeting the viral capsid in acute-resolving hepatitis E infection. J Hepatol. 2023 Dec 26:S0168-8278(23)05370-9. doi: 10.1016/j.jhep.2023.12.016. (TP01, TP02, TP04, TP20, TP21, TP22)

Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Corrigendum to "Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation" [J Hepatol (2023) 645-656]. J Hepatol. 2023 Nov 30:S0168-8278(23)05282-0. doi: 10.1016/j.jhep.2023.11.007. Erratum for: J Hepatol. 2023 Sep;79(3):645-656. (TP05, TP06, TP20, Z03)

Guo H, Li Q, Li C, Hou Y, Ding Y, Liu D, Ni Y, Tang R, Zheng K, Urban S, Wang W. Molecular determinants within the C-termini of L-HDAg that regulate hepatitis D virus replication and assembly. JHEP Rep. 2023 Nov 15;6(1):100961. doi: 10.1016/j.jhepr.2023.100961. (TP15)

Sandy S Burkart, Darius Schweinoch, Jamie Frankish, Carola Sparn, Sandra Wüst, Christian Urban, Marta Merlo, Vladimir G Magalhães, Antonio Piras, Andreas Pichlmair, Joschka Willemsen, Lars Kaderali, Marco Binder (2023) Life Science Alliance Aug 2023, 6 (10) e202302059; DOI: 10.26508/lsa.202302059 (TP11)

Guo H, Li Q, Li C, Hou Y, Ding Y, Liu D, Ni Y, Tang R, Zheng K, Urban S, Wang W. Molecular determinants within the C-termini of L-HDAg that regulate hepatitis D virus replication and assembly. JHEP Rep. 2023 Nov 15;6(1):100961. doi: 10.1016/j.jhepr.2023.100961. (TP15)

Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Gross O, Pearce EL, Herrmann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B. Enolase represents a metabolic checkpoint controlling the differential exhaustion programs of hepatitis virus-specific CD8+ T cells. Gut. 2023 Oct;72(10):1971-1984. doi: 10.1136/gutjnl-2022-328734. (TP01, TP02, TP04, TP05, TP13, TP20, TP21, Z03)

Pham MT, Lee JY, Ritter C, Thielemann R, Meyer J, Haselmann U, Funaya C, Laketa V, Rohr K, Bartenschlager R. Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the
hepatitis C virus. PLoS Pathog. 2023 Jul 28;19(7):e1011052. doi: 10.1371/journal.ppat.1011052. (TP09)

Allweiss L, Testoni B, Yu M, Lucifora J, Ko C, Qu B, Lütgehetmann M, Guo H, Urban S, Fletcher SP, Protzer U, Levrero M, Zoulim F, Dandri M. (2023) Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure. Gut. 72(5):972-983. doi: 10.1136/gutjnl-2022-328380. (TP14, TP15)

Anolli MP, Degasperi E, Allweiss L, Sangiovanni A, Maggioni M, Scholtes C, Oberhardt V, Neumann-Haefelin C, Dandri M, Zoulim F, Lampertico P. (2023) A 3-year course of bulevirtide monotherapy may cure HDV infection in cirrhotics. J Hepatol. 78(4): 876-880. doi: 10.1016/j.jhep.2022.12.023. (TP02)

Magalhães VG, Lukassen S, Drechsler M, Loske J, Burkart SS, Wüst S, Jacobsen E-M, Röhmel J, Mall MA, Debatin K-M, Eils R, Autenrieth S, Janda A, Lehmann I, Binder M. (2023) Enhanced airway epithelial response to SARS-CoV-2 infection in children is critically tuned by the cross-talk between immune and epithelial cells. bioRxi. doi: 10.1101/2023.05.17.541103.(TP11)

Hackstein CP*, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kummerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA*, Abdullah Z*. (2023) Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. J Hepatol. S0168-8278(23)00158-7. doi: 10.1016/j.jhep.2023.02.026. (TP05)

Poos AM, Prokoph N, Przybilla MJ, Mallm JP, Steiger S, Seufert I, John L, Tirier SM, Bauer K, Baumann A, Rohleder J, Munawar U, Rasche L, Kortum KM, Giesen N, Reichert P, Huhn S, Muller-Tidow C, Goldschmidt H, Stegle O, Raab MS, Rippe K*, Weinhold N* (2023) Resolving therapy resistance mechanisms in multiple myeloma by multi-omics subclone analysis. Blood Jun 30;blood.2023019758. doi: 10.1182/blood.2023019758. (Z03)

Pfister S, Rabl J, Wiegand T, Mattei S, Malär AA, Lecoq L, Seitz S, Bartenschlager R, Böckmann A, Nassal M, Boehringer D, Meier BH. (2023) Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style. Nat Commun. 14:1574. doi.org/10.1038/s41467-023-37068-w. (TP09, TP23)

Hofmann S, Plank V, Groitl P, Skvorc N, Hofmann K, Luther J, Ko C, Zimmerman P, Bruss V, Stadler D, Carpentier A, Rezk S, Nassal M, Protzer U, Schreiner S. SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA. Microbiol Spectr. 2023 May 18:e0044623. doi: 10.1128/spectrum.00446-23. (TP14, TP16)

Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie C, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FWF, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation. J Hepatol. 2023 Apr 28;S0168-8278(23)00309-4. doi: 10.1016/j.jhep.2023.04.023. (TP06, TP09, TP11, TP17)

Kotsiliti E, ..., Hofmann M, Rippe K, Zitzlesberger H, Weber A, Malek N, Lüdde T, Vucur M, Augustin HG, Flavell R, Parnas O, Rad R, Pabst O, Henderson NC, Huber S, Macpherson A, Knolle P, Claasen M, Geier A, Trautwein C, Unger K, Elinav E, Waisman A, Abdullah Z, Haller D, Tacke F, Anstee QM, Heikenwalder M. (2023) Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling. J Hepatol. 2023 May 9:S0168-8278(23)00325-2. doi: 10.1016/j.jhep.2023.04.037. (TP05, TP06, TP20, Z03)

Wedemeyer H, Schöneweis K,Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Urban S. Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial. Lancet Infect Dis. 2023 Jan;23(1):117-129. doi: 10.1016/S1473-3099(22)00318-8. (TP15)

Luxenburger H, Neumann-Haefelin C. Liver-resident CD8+ T cells in viral hepatitis: not always good guys. J Clin Invest. 2023 Jan 3;133(1):e165033. doi: 10.1172/JCI165033. (TP02)

Luxenburger H, Reeg D, Lang-Meli J, Reinscheid M, Eisner M, Bettinger D, Oberhardt V, Alizei ES, Wild K,Graeser A, Karl V, Sagar, Emmerich F, Klein F, Panning M, Huzly D, Bengsch B, Boettler T, Elling R, Thimme R, Hofmann M, Neumann-Haefelin C. Boosting compromised SARS-CoV-2-specific immunity with mRNA vaccination in liver transplant recipients. J Hepatol 2023, May;78(5):1017-1027. doi: 10.1016/j.jhep.2023.02.007. (TP01, TP02, TP04, TP20, TP21).

Su J, Brunner L, Ates Oz E, Sacherl J, Frank G, Kerth HA, Thiele F, Wiegand M, Mogler C, Aguilar JC, Knolle PA, Collin N, Kosinska AD, Protzer U. Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models. J Hepatol. 2023 Apr;78(4):717-730. doi: 10.1016/j.jhep.2022.12.013. (TP05, TP18, Z02)

Wührl M, Ringelhan M, Ehmer U, Schneider J, Kager J, Lahmer T, Schneider A, Weichert W, Mogler C. (Seltene) infektiöse Hepatitiden als wichtige Differenzialdiagnose der unklaren Hepatopathie. Pathologie (Heidelb). 2023 Feb;44(1):53-62. German. doi: 10.1007/s00292-022-01167-0. (Z02)

Esser K, Cheng X, Wettengel JM, Lucifora J, Hansen-Palmus L, Austen K, Roca Suarez AA, Heintz S, Testoni B, Nebioglu F, Pham MT, Yang S, Zernecke A, Wohlleber D, Ringelhan M, Broxtermann M, Hartmann D, Hüser N, Mergner J, Pichlmair A, Thasler WE, Heikenwalder M, Gasteiger G, Blutke A, Walch A, Knolle PA, Bartenschlager R, Protzer U. (2023) Hepatitis B virus targets lipid transport pathways to infect hepatocytes,Cellular and Molecular Gastroenterology and Hepatology, 2023,ISSN 2352-345X,https://doi.org/10.1016/j.jcmgh.2023.03.011. (TP05, TP06, TP09, TP11, TP13, TP14)

Muckenhuber M, Seufert I, Müller-Ott K, Mallm JP, Klett LC, Knotz C, Hechler J, Kepper N, Erdel F, Rippe K. Epigenetic signals that direct cell type-specific interferon beta response in mouse cells. Life Sci Alliance. 2023 Feb 2;6(4):e202201823. doi: 10.26508/lsa.202201823. (Z03)



2022

Sacherl J, Kosinska AD, Kemter K, Kächele M, Laumen SC, Kerth HA, Öz EA, Wolff LS, Su J, Essbauer S, Sutter G, Scholz M, Singethan K, Altrichter J, Protzer U. Efficient stabilization of therapeutic hepatitis B vaccine components by amino-acid formulation maintains its potential to break immune tolerance. JHEP Rep. 2022 Oct 13;5(2):100603. doi: 10.1016/j.jhepr.2022.100603. (TP18)

Isken O, Pham MT, Schwanke H, Schlotthauer F, Bartenschlager R, et al. (2022) Characterization of a multipurpose NS3 surface patch coordinating HCV replicase assembly and virion morphogenesis. PLOS Pathogens 18(10): e1010895. https://doi.org/10.1371/journal.ppat.1010895 (TP09)

Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. (TP09)

Gillich N, Zhang Z, Binder M, Urban S, Bartenschlager R. Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication. J Hepatol. 2022 Sep 21:S0168-8278(22)03113-0. doi: 10.1016/j.jhep.2022.08.041. (TP09, TP11, TP15)

Zhang Z, Ni Y, Lempp FA, Walter L, Mutz P, Bartenschlager R, Urban S. Hepatitis D virus-induced interferon response and administered interferons control cell division-mediated virus spread. J Hepatol. 2022 Oct;77(4):957-966. doi: 10.1016/j.jhep.2022.05.023. (TP09, TP15)

Qu B, Nebioglu F, Leuthold MM, Ni Y, Mutz P, Beneke J, Erfle H, Vondran FWR, Bartenschlager R, Urban S, Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen, JHEP Reports, 2022, 100551, ISSN 2589-5559, https://doi.org/10.1016/j.jhepr.2022.100551. (TP09, TP15)

Dudek M, Lohr K, Donakonda S, Baumann T, Lüdemann M, Hegenbarth S, Dübbel L, Eberhagen C, Michailidou S, Yassin A, Prinz M, Popper B, Rose-John S, Zischka H, Knolle PA. IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells. Cell Rep. 2022 Feb 15;38(7):110389. doi: 10.1016/j.celrep.2022.110389. (TP05)

Lang-Meli J, Neumann-Haefelin C. Prophylactic vaccination against hepatitis D virus superinfection: from fiction to reality? Gut. 2022 Oct 19;gutjnl-2022-328381. doi: 10.1136/gutjnl-2022-328381. (TP02)

Chen P, Wojdyla JA, Colasanti O, Li Z, Qin B, Wang M, Lohmann V, Cui S. Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA. Nucleic Acids Res. 2022 Aug 10:gkac671. doi: 10.1093/nar/gkac671. (TP17)

Reinscheid M, Luxenburger H, Karl V, Graeser A, Giese S, Ciminski K, Reeg DB, Oberhardt V, Roehlen N, Lang-Meli J, Heim K, Gross N, Baum C, Rieg S, Speer C, Emmerich F, Breisinger S, Steinmann D, Bengsch B, Boettler T, Kochs G, Schwemmle M, Thimme R, Neumann-Haefelin C, Hofmann M. COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation. Nat Commun. 2022 Aug 8;13(1):4631. doi: 10.1038/s41467-022-32324-x. (TP01,TP02, TP04, TP20, TP21)

Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B. T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. (TP01, TP02, TP04, TP20, TP21)

Tu T, Zehnder B, Wettengel JM, Zhang H, Coulter S, Ho V, Douglas MW, Protzer U, George J, Urban S. Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells. JHEP Rep. 2022 Jun 15;4(9):100514. doi: 10.1016/j.jhepr.2022.100514. (TP15, TP14, TP18)

Mai J, Stubbe M, Hofmann S, Masser S, Dobner T, Boutell C, Groitl P, Schreiner S. PML alternative splice products differentially regulate HAdV productive infection. Microbiol Spectr. 2022 Aug 31;10(4):e0078522. doi: 10.1128/spectrum.00785-22. (TP16)

Debelec-Butuner B, Quitt O, Schreiber S, Momburg F, Wisskirchen K, Protzer U. Activation of distinct antiviral T-cell immunity: A comparison of bi- and trispecific T-cell engager antibodies with a chimeric antigen receptor targeting HBV envelope proteins. Frontiers in Immunology 2022, 13: 1029214e (TP16)

Kim ES, Zhou J, Zhang H, Marchetti A, van de Klundert M, Cai D, Yu X, Mitra B, Liu Y, Wang M, Protzer U, Guo H. Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA. PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576. (TP14, TP18)

Heuss C, Rothhaar P, Burm R, Lee JY, Ralfs P, Uta Haselmann,Luisa J. Ströh, Colasanti O, Tran C S, Schäfer N, Schnitzler P, Merle U, Bartenschlager R, Patel A, Graw F, Krey T, Laketa V, Meuleman P, Lohmann V (2022) A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo. PLOS Pathogens 18(6): e1010472. https://doi.org/10.1371/journal.ppat.1010472 (TP09, TP17)

Lorenza A. D’Alessandro, Ursula Klingmüller, Marcel Schilling; Deciphering signal transduction networks in the liver by mechanistic mathematical modelling. Biochem J 30 June 2022; 479 (12): 1361–1374. doi: https://doi.org/10.1042/BCJ20210548 (TP10)

Silva DN, Chrobok M, Rovesti G, Healy K, Wagner AK, Maravelia P, Gatto F, Mazza M, Mazzotti L, Lohmann V, Sällberg Chen M, Sällberg M, Buggert M, Pasetto A. Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products. Front Immunol. 2022 Jun 16;13:896242. doi: 10.3389/fimmu.2022.896242. (TP17)

Zhang C, Freistaedter A, Schmelas C, Gunkel M, Dao Thi VL, Grimm D. An RNA Interference/Adeno-Associated Virus Vector-Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus. Hepatol Commun. 2022 Apr;6(4):878-888. doi: 10.1002/hep4.1842 (TP18, TP22)

Harati Taji Z, Bielytskyi P, Shein M, Sani MA, Seitz S, Schütz AK. Transient RNA Interactions Leave a Covalent Imprint on a Viral Capsid Protein. J Am Chem Soc. 2022 May 18;144(19):8536-8550. doi: 10.1021/jacs.1c12439. (TP23)

Kemming J, Gundlach S, Panning M, Huzly D, Huang J, Lütgehetmann M, Pischke S, Schulze zur Wiesch J, Emmerich F, Llewellyn-Lacey S, Price DA, Tanriver Y, Warnatz K, Boettler T, Thimme R, Hofmann M, Fischer N, Neumann-Haefelin C, Mechanisms of CD8+ T-cell failure in chronic hepatitis E virus infection, Journal of Hepatology, 2022, https://doi.org/10.1016/j.jhep.2022.05.019. (TP01, TP02, TP04, TP20)

Lang-Meli J, Luxenburger H, Wild K, Karl V, Oberhardt V, Salimi Alizei E, Graeser A, Reinscheid M, Roehlen N, Reeg DB, Giese S, Ciminski K, Götz V, August D, Rieg S, Waller CF, Wengenmayer T, Staudacher D, Huzly D, Bengsch B, Kochs G, Schwemmle M, Emmerich F, Boettler T, Thimme R, Hofmann M, Neumann-Haefelin C. SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals. Nat Microbiol. 2022 Apr 28. doi: 10.1038/s41564-022-01106-y. (TP01, TP02, TP04, TP20, TP21)

Zander DY, Burkart SS, Wüst S, Magalhães VG, Binder M. Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death. Cell Death Dis. 2022 Apr 18;13(4):364. doi: 10.1038/s41419-022-04797-7. (TP11)

Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Alizei ES , Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M, Bengsch B SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis, Journal of Hepatology, 2022, https://doi.org/10.1016/j.jhep.2022.03.040. (TP01, TP02, TP04, TP20, TP21, Z02)

Boettler T , Gill U S, Allweiss L., Pollicino T., Tavis J E, Zoulim F, Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection, JHEP Reports, Volume 4(6), 2022, 100480, ISSN 2589-5559, https://doi.org/10.1016/j.jhepr.2022.100480. (TP04)

Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng CC, Yazici S, Christa C, Jeske S, Lupoli G, Vogt T, Albanese M, Mejías-Pérez E, Bauernfried S, Graf N, Mijocevic H, Vu M, Tinnefeld K, Wettengel J, Hoffmann D, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle P, Keppler OT, Protzer U. Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern. Nat Med. 2022 Mar;28(3):496-503. doi: 10.1038/s41591-022-01715-4. (TP05, TP14, TP18)

Siegler JJ, Correia MP, Hofman T, Prager I, Birgin E, Rahbari NN, Watzl C, Stojanovic A, Cerwenka A. (2022) Human ILC3 exert TRAIL-mediated cytotoxicity towards cancer cells. Front Immunol. 13:742571. doi: 10.3389/fimmu.2022.742571. (TP07)

Koerber N, Priller A , Yazici S, Bauer T, Cheng CC, Mijočević H, Wintersteller H, Jeske S, Vogel E, Feuerherd M, Tinnefeld K, Winter C, Ruland J, Gerhard M, Haller B, Christa C, Zelger O, Roggendorf H, Halle M, Erber J, Lingor P, Keppler O, Zehn D, Protzer U, Knolle PA. Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents. Nat Commun 13, 153 (2022). https://doi.org/10.1038/s41467-021-27649-y (TP05, TP14, TP18)

Bunse T, Kosinska AD, Michler T, Protzer U. PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B. Biomolecules. 2022 Mar 18;12(3):470. doi: 10.3390/biom12030470. (TP14, TP18)

Brugger M, Laschinger M, Lampl S, Schneider A, Manske K, Esfandyari D, Hüser N, Hartmann D, Steiger K, Engelhardt S, Wohlleber D, Knolle PA. High precision-cut liver slice model to study cell-autonomous antifviral defense of hepatocytes within their microenvironment. JEHP Rep. 2022 Mar 6;4(56):100465. doi: 10.1016/j.hepr.2022.100465 (TP05, TP13)

Harbauer AB, Schneider A, Wohlleber D. Analysis of Mitochondria by Single-Organelle Resolution. Annu Rev Anal Chem (Palo Alto Calif). 2022 Feb 18. doi: 10.1146/annurev-anchem-061020-111722 (TP13)

Maurer L, El Andari J, Rapti K, Spreyer L, Steinmann E, Grimm D, Dao Thi VL. Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector. Viruses. 2022 Jan 27;14(2):266. doi: 10.3390/v14020266. (TP18, TP22)

Oberhardt V, Hofmann M, Thimme R, Neumann-Haefelin C. Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection. Viruses. 2022 Jan 20;14(2):198. doi: 10.3390/v14020198. (TP01, TP02, TP04, TP20)

Neufeldt CJ, Cerikan B, Cortese M, Frankish J, Lee JY, Plociennikowska A, Heigwer F, Prasad V, Joecks S, Burkart SS, Zander DY, Subramanian B, Gimi R, Padmanabhan S, Iyer R, Gendarme M, El Debs B, Halama N, Merle U, Boutros M, Binder M, Bartenschlager R. SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB. Commun Biol. 2022 Jan 12;5(1):45. doi: 10.1038/s42003-021-02983-5.
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Wagner KI, Mateyka LM, Jarosch S, Grass V, Weber S, Schober K, Hammel M, Burrell T, Kalali B, Poppert H, Beyer H, Schambeck S, Holdenrieder S, Strötges-Achatz A, Haselmann V, Neumaier M, Erber J, Priller A, Yazici S, Roggendorf H, Odendahl M, Tonn T, Dick A, Witter K, Mijočević H, Protzer U, Knolle PA, Pichlmair A, Crowell CS, Gerhard M, D'Ippolito E, Busch DH. Recruitment of highly cytotoxic CD8+ T cell receptors in mild SARS-CoV-2 infection. Cell Rep. 2022 Jan 11;38(2):110214. doi: 10.1016/j.celrep.2021.110214 (TP05, TP11, TP14)



2021

Wild K, Smits M, Killmer S, Strohmeier S, Neumann-Haefelin C, Bengsch B, Krammer F, Schwemmle M, Hofmann M, Thimme R, Zoldan K, Boettler T. Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination. Nat Commun. 2021 Nov 18;12(1):6720. doi: 10.1038/s41467-021-27064-3. (TP01, TP02, TP04, TP20, TP21)

Maurer L, El Andari J, Rapti K, Spreyer L, Steinmann E, Grimm D, Dao Thi VL. Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector. Viruses. 2022; 14(2):266. https://doi.org/10.3390/v14020266 (TP18, TP22)

Delphin M, Desmares M, Schuehle S, Heikenwalder M, Durantel D, Faure-Dupuy S. How to get away with liver innate immunity? A viruses' tale. Liver Int. 2021 Nov;41(11):2547-2559. doi: 10.1111/liv.15054. (TP06)

Lempp FA, Roggenbach I, Nkongolo S, Sakin V, Schlund F, Schnitzler P, Wedemeyer H, Le Gal F, Gordien E, Yurdaydin C, Urban S. A Rapid Point-of-Care Test for the Serodiagnosis of Hepatitis Delta Virus Infection Viruses. 2021 Dec; 13(12): 2371. Published online 2021 Nov 26. doi: 10.3390/v13122371 (TP15)

Schreiber S, Honz M, Mamozai W, Kurktschiev P, Schiemann M, Witter K, Moore E, Zielinski C, Sette A, Protzer U, Wisskirchen K. Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors. Mol Ther Methods Clin Dev. 2021 Oct 29;23:476-489. doi: 10.1016/j.omtm.2021.10.012.(TP18, Z02)

Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A. NUDT2 initiates viral RNA degradation by removal of 5′-phosphates Nat Commun. 2021; 12: 6918. doi: 10.1038/s41467-021-27239-y (TP11, TP18)

Altstetter, S.M.; Quitt, O.; Pinci, F.; Hornung, V.; Lucko, A.M.; Wisskirchen, K.; Jung, S.; Protzer, U. Hepatitis-D Virus Infection Is Not Impaired by Innate Immunity but Increases Cytotoxic T-Cell Activity Cells. 2021 Nov; 10(11): 3253. doi: 10.3390/cells10113253 (TP14)

Knolle PA, Huang LR, Kosinska A, Wohlleber D, Protzer U. Improving Therapeutic Vaccination against Hepatitis B-Insights from Preclinical Models of Immune Therapy against Persistent Hepatitis B Virus Infection. Vaccines (Basel). 2021 Nov 16;9(11):1333. doi: 10.3390/vaccines9111333. (TP05, TP18)

Manske K, Schneider A, Ko C, Knolle PA, Steiger K, Protzer U, Wohlleber D.In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity Viruses. 2021 Nov; 13(11): 2273. doi: 10.3390/v13112273 (TP05, TP18)

Tabata K, Prasad V, Paul D, Lee JY, Pham MT, Twu WI, Neufeldt CJ, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Lüchtenborg C, V'kovski P, Hörmann K, Müller AC, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brügger B, Bartenschlager R. Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun. 2021 Dec 14;12(1):7276. doi: 10.1038/s41467-021-27511-1. (TP09, TP17)

Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, Tabata K, Bartenschlager R. Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation. Cell Rep. 2021 Nov 23;37(8):110049. doi: 10.1016/j.celrep.2021.110049. (TP09)

Quitt O, Luo S, Meyer M, Xie Z, Golsaz-Shirazi F, Loffredo-Verde E, Festag J, Bockmann JH, Zhao L, Stadler D, Chou WM, Tedjokusumo R, Wettengel JM, Ko C, Noeßner E, Bulbuc N, Shokri F, Lüttgau S, Heikenwälder M, Bohne F, Moldenhauer G, Momburg F, Protzer U. T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice. J Hepatol. 2021 Nov;75(5):1058-1071. doi: 10.1016/j.jhep.2021.06.022. (TP06, TP14)

Rapti K., Grimm D. Adeno-Associated Viruses (AAV) and Host Immunity – A Race Between the Hare and the Hedgehog Front Immunol. 2021; 12: 753467. doi: 10.3389/fimmu.2021.753467 (TP18)

Roggenbach I, Chi X, Lempp FA, Qu B, Walter L, Wu R, Gao X, Schnitzler P, Ding Y, Urban S, Niu J. HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection. Viruses. 2021 Sep 10;13(9):1799. doi: 10.3390/v13091799. (TP15)

Faure-Dupuy S, Riedl T, Rolland M, Hizir Z, Reisinger F, Neuhaus K, Schuehle S, Remouchamps C, Gillet N, Schönung M, Stadler M, Wettengel J, Barnault R, Parent R, Schuster LC, Farhat R, Prokosch S, Leuchtenberger C, Öllinger R, Engleitner T, Rippe K, Rad R, Unger K, Tscharahganeh D, Lipka DB, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwälder M. Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p. JHEP Rep. 2021 Aug 25;3(6):100354. doi: 10.1016/j.jhepr.2021.100354. (TP06, TP14)

Salimi Alizei E, Hofmann M, Thimme R, Neumann-Haefelin C. Mutational escape from cellular immunity in viral hepatitis: variations on a theme. Curr Opin Virol. 2021 Oct;50:110-118. doi: 10.1016/j.coviro.2021.08.002. (TP01, TP02, TP20)

Oswald A, Chakraborty A, Ni Y, Wettengel JM, Urban S, Protzer U. Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus. Sci Rep. 2021 Oct 5;11(1):19799. doi: 10.1038/s41598-021-99263-3. (TP14, TP15)

Wüst S, Schad P, Burkart S, Binder M. Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses. Cells. 2021 Sep 30;10(10):2600. doi: 10.3390/cells10102600. (TP11)

Zoldan K, Ehrlich S, Killmer S, Wild K, Smits M, Russ M, Globig AM, Hofmann M, Thimme R, Boettler T. Th1-Biased Hepatitis C Virus-Specific Follicular T Helper-Like Cells Effectively Support B Cells After Antiviral Therapy. Front Immunol. 2021 Sep 30;12:742061. doi: 10.3389/fimmu.2021.742061. (TP01, TP04, TP20)

Urban S, Neumann-Haefelin C, Lampertico P. Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease. Gut. 2021 Sep;70(9):1782-1794. doi: 10.1136/gutjnl-2020-323888. (TP02, TP15)

Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T, Bengsch B, Thimme R, Hofmann M, Neumann-Haefelin C. Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nat Med. 2021 Jan;27(1):78-85. doi: 10.1038/s41591-020-01143-2. (TP01, TP02, TP04, TP20, TP21)

Kosinska, A.D.; Festag, J.; Mück-Häusl, M.; Festag, M.M.; Asen, T.; Protzer, U. Immunogenicity and Antiviral Response of Therapeutic Hepatitis B Vaccination in a Mouse Model of HBeAg-Negative, Persistent HBV Infection Vaccines (Basel) 2021 Aug; 9(8): 841. doi: 10.3390/vaccines9080841 (TP14)

Wettengel, J.M., Linden, B., Esser, K., Laue, M., Burwitz, B.J., Protzer, U Rapid and Robust Continuous Purification of High-Titer Hepatitis B Virus for In Vitro and In Vivo Applications Viruses. 2021 Aug; 13(8): 1503. doi: 10.3390/v13081503 (TP14)

Kremer LPM, Cerrizuela S, Dehler S, Stiehl T, Weinmann J, Abendroth H, Kleber S, Laure A, El Andari J, Anders S, Marciniak-Czochra A, Grimm D, Martin-Villalba A. High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone. Mol Ther Methods Clin Dev. 2021 Jul 16;23:33-50. doi: 10.1016/j.omtm.2021.07.001. (TP18)

Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I. Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol. 2021 Aug 18. doi: 10.1038/s41587-021-01037-9. (TP11)

Koch J, Uckeley ZM, Doldan P, Stanifer M, Boulant S, Lozach PY. TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. EMBO J. 2021 Aug 16;40(16):e107821. doi: 10.15252/embj.2021107821. (TP22)

Chen Q, Coto-Llerena M, Suslov A, Teixeira RD, Fofana I, Nuciforo S, Hofmann M, Thimme R, Hensel N, Lohmann V, Ng CKY, Rosenberger G, Wieland S, Heim MH. Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nat Commun. 2021 Aug 12;12(1):4882. doi: 10.1038/s41467-021-25218-x. (TP01, TP17, TP20)

Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U. Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20. EMBO Rep. 2021 Jun 4;22(6):e49568. doi: 10.15252/embr.201949568. (TP06, TP09, TP11, TP14, TP16)

Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M. Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine. Nature. 2021 Sep;597(7875):268-273. doi: 10.1038/s41586-021-03841-4. (TP01, TP02, TP04, TP20)

Kamel W, Noerenberg M, Cerikan B, Chen H, Järvelin AI, Kammoun M, Lee JY, Shuai N, Garcia-Moreno M, Andrejeva A, Deery MJ, Johnson N, Neufeldt CJ, Cortese M, Knight ML, Lilley KS, Martinez J, Davis I, Bartenschlager R, Mohammed S, Castello A. Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection. Mol Cell. 2021 Jul 1;81(13):2851-2867.e7. doi: 10.1016/j.molcel.2021.05.023. (TP09)

Rappez L, Stadler M, Triana S, Gathungu RM, Ovchinnikova K, Phapale P, Heikenwalder M, Alexandrov T. SpaceM reveals metabolic states of single cells. Nat Methods. 2021 Jul;18(7):799-805. doi: 10.1038/s41592-021-01198-0. (TP06)

Rennert C, Tauber C, Fehrenbach P, Heim K, Bettinger D, Sogukpinar Ö, Schuch A, Zecher BF, Bengsch B, Lang SA, Bronsert P, Björkström NK, Fichtner-Feigl S, Schultheiss M, Thimme R, Hofmann M. Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma. Cells. 2021 Jun 2;10(6):1369. doi: 10.3390/cells10061369. (TP01, TP20, TP21)

Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252. doi: 10.1038/s41586-021-03493-4. (TP11, TP14, TP18)

Deczkowska A, David E, Ramadori P, Pfister D, Safran M, At The B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A, Ben-Ari Z, Heikenwälder M, Elinav E, Amit I. XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis. Nat Med. 2021 Jun;27(6):1043-1054. doi: 10.1038/s41591-021-01344-3. (TP06)

Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Thimme R, Bengsch B. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions. Immunity. 2021 Jun 9. doi: 10.1016/j.immuni.2021.06.002. (TP01, TP02, TP04, TP20, TP21)

Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenbergeg C, Schneider M, Heßling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwalder M. HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence. Hepatology. 2021 May 15. doi: 10.1002/hep.31902.(TP06, TP14)

Dudek, M., Pfister, D., Donakonda, S. ...R. Thimme, T. Böttler, F. Tacke, J.-F. Dufour, D. Haller, P. J. Murray, R. Heeren, D. Zehn, J.P. Böttcher, M. Heikenwälder & Percy A. Knolle Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH. Nature 592, 444–449 (2021). (TP01, TP04, TP05, TP06)

Hofmann S, Stubbe M, Mai J, Schreiner S. Double-edged role of PML nuclear bodies during human adenovirus infection. Virus Res. 2021 Apr 2;295:198280. doi: 10.1016/j.virusres.2020.198280. (TP16)

Flommersfeld S, Böttcher JP, Ersching J, Flossdorf M, Meiser P, Pachmayr LO, Leube J, Hensel I, Jarosch S, Zhang Q, Zeeshan Chaudhry M, Andrae I, Schiemann M, Busch DH, Cicin-Sain L, Sun JC, Gasteiger G, Victora GD, Höfer T, Buchholz VR, Grassmann S. Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. 2021 Immunity. 54:2288-2304 e2287. (Z02)

Pfister, D., Núñez, N.G., Pinyol, R., ... Knolle P, ... Heikenwalder M (2021) NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature (2021). https://doi.org/10.1038/s41586-021-03362-0 (TP05, TP06)

Tu T, Zhang H, Urban S. Hepatitis B Virus DNA Integration: In Vitro Models for Investigating Viral Pathogenesis and Persistence. Viruses. 2021 Jan 26;13(2):180. doi: 10.3390/v13020180. (TP15)

Schuren, A., Boer, I., Bouma, E. M., Van de Weijer, M. L., Costa, A. I., Hubel, P., Pichlmair, A., Lebbink, R. J., & Wiertz, E. (2021). The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I. Molecules (Basel, Switzerland), 26(2), 287. https://doi.org/10.3390/molecules26020287 (TP11)

Basho K, Zoldan K, Schultheiss M, Bettinger D, Globig A-M, Bengsch B, Neumann-Haefelin C, Klocperk A, Warnatz K, Hofmann M, Thimme R, Boettler T. IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis. J Hepatol. 2021 Mar;74(3):649-660. doi: 10.1016/j.jhep.2020.10.012. (TP01, TP02, TP04, TP20)

Zhang C, Freistaedter A, Schmelas C, Gunkel M, Dao Thi VL, Grimm D. An RNA Interference/Adeno-Associated Virus Vector-Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus. 2021 Hepatol Commun doi: 10.1002/hep4.1842 (TP18, TP22)

Hensel N, Gu Z, Sagar, Wieland D, Jechow K, Kemming J, Llewellyn-Lacey S, Gostick E, Sogukpinar O, Emmerich F, Price DA, Bengsch B, Boettler T, Neumann-Haefelin C, Eils R, Conrad C, Bartenschlager R, Grün D, Ishaque N, Thimme R, Hofmann M. Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection. Nat Immunol. 2021 Feb;22(2):229-239. doi: 10.1038/s41590-020-00817-w. (TP01, TP02, TP04, TP09, TP 20, TP21)

Conlon TM, John-Schuster G, Heide D, Pfister D, Lehmann M, Hu Y, Ertüz Z, Lopez MA, Ansari M, Strunz M, Mayr C, Angelidis I, Ciminieri C, Costa R, Kohlhepp MS, Guillot A, Günes G, Jeridi A, Funk MC, Beroshvili G, Prokosch S, Hetzer J, Verleden SE, Alsafadi H, Lindner M, Burgstaller G, Becker L, Irmler M, Dudek M, Janzen J, Goffin E, Gosens R, Knolle P, Pirotte B, Stoeger T, Beckers J, Wagner D, Singh I, Theis FJ, de Angelis MH, O'Connor T, Tacke F, Boutros M, Dejardin E, Eickelberg O, Schiller HB, Königshoff M, Heikenwalder M, Yildirim AÖ. Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung. Nature. 2021 Jan;589(7842):E6. doi: 10.1038/s41586-020-03087-6. Erratum for: Nature. 2020 Dec;588(7836):151-156. (TP05, TP06)

Thimme R. T cell immunity to hepatitis C virus: Lessons for a prophylactic vaccine. J Hepatol. 2021 Jan;74(1):220-229. doi: 10.1016/j.jhep.2020.09.022.(TP01)



2020

Heim K, Binder B, Sagar, Wieland D, Hensel N, Llewellyn-Lacey S, Gostick E, Price DA, Emmerich F, Vingerhoet H, Kraft ARM, Cornberg M, Boettler T, Neumann-Haefelin C, Zehn D, Bengsch B, Hofmann M, Thimme R. TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut. 2021 Aug; 70(8): 1550–1560. (TP01, TP02, TP04, TP20)

Zhang Z, Urban S. New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies. J Hepatol. 2021 Mar;74(3):686-699. doi: 10.1016/j.jhep.2020.11.032. (TP15)

Krey K, Babnis AW, Pichlmair A. System-Based Approaches to Delineate the Antiviral Innate Immune Landscape. Viruses. 2020 Oct 21;12(10):1196. doi: 10.3390/v12101196. (TP11)

Jung, S., Jacobs, K., Shein, M., Schütz, A. K., Mohr, F., Stadler, H., Stadler, D., Lucko, A. M., Altstetter, S. M., Wilsch, F., Deng, L., Protzer, U (2020). Efficient and reproducible depletion of hepatitis B virus from plasma derived extracellular vesicles. Journal of extracellular vesicles, 10(2), e12040. https://doi.org/10.1002/jev2.12040 (TP14, TP23)

Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R. 2020. Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies. Cell Host Microbe. 2020 Nov 17:S1931-3128(20)30620-X. doi: 10.1016/j.chom.2020.11.003. (TP09, TP22)

Tu, T., Zehnder, B., Qu, B., & Urban, S. (2020). De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA. JHEP reports : innovation in hepatology, 3(1), 100195. https://doi.org/10.1016/j.jhepr.2020.100195 (TP15)

Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T, Bengsch B, Thimme R, Hofmann M, Neumann-Haefelin C. Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nat Med. 2020 Nov 12. doi: 10.1038/s41591-020-01143-2. (TP01, TP02, TP04, TP11, TP20, TP21)

Robichon K, Maiwald T, Schilling M, Schneider A, Willemsen J, Salopiata F, Teusel M, Kreutz C, Ehlting C, Huang J, Chakraborty S, Huang X, Damm G, Seehofer D, Lang PA, Bode JG, Binder M, Bartenschlager R, Timmer J, Klingmüller U. Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses. PLoS Pathog. 2020 Oct 1;16(10):e1008461. doi: 10.1371/journal.ppat.1008461. (TP09, TP10, TP11)

Vassilaki N, Frakolaki E, Kalliampakou KI, Sakellariou P, Kotta-Loizou I, Bartenschlager R, Mavromara P. 2020. A Novel Cis-Acting RNA Structural Element Embedded in the Core Coding Region of the Hepatitis C Virus Genome Directs Internal Translation Initiation of the Overlapping Core+1 ORF. Int J Mol Sci. 2020 Sep 22;21(18):E6974. doi: 10.3390/ijms21186974. (TP09)

Tu T, Zehnder B, Qu B, Ni Y, Main N, Allweiss L, Dandri M, Shackel N, George J, Urban S. A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance. Antiviral Res. 2020 Sep;181:104865. doi: 10.1016/j.antiviral.2020.104865. (TP15)

Kemming J, Thimme R, Neumann-Haefelin C. Adaptive Immune Response against Hepatitis C Virus. Int J Mol Sci. 2020 Aug 6;21(16):5644. doi: 10.3390/ijms21165644. (TP01, TP02)

Urban C, Welsch H, Heine K, Wüst S, Haas DA, Dächert C, Pandey A, Pichlmair A, Binder M. Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis. Viruses. 2020 Jun 11;12(6):635. doi: 10.3390/v12060635. (TP11)

Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Kläger S, Küster B, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perocchi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. J Hepatol. 2020 Jun 26:S0168-8278(20)30398-6. doi: 10.1016/j.jhep.2020.06.026. (TP05, TP06, TP10, TP11, TP13, TP16, TP18)

Kok F, Rosenblatt M, Teusel M, Nizharadze T, Gonçalves Magalhães V, Dächert C, Maiwald T, Vlasov A, Wäsch M, Tyufekchieva S, Hoffmann K, Damm G, Seehofer D, Boettler T, Binder M, Timmer J, Schilling M, Klingmüller U. 2020. Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction. Molecular Systems Biology 2020 Jul;16(7):e8955. doi: 10.15252/msb.20198955. (TP10)

Seitz S, Habjanič J, Schütz AK, Bartenschlager R. 2020. The Hepatitis B Virus Envelope Proteins: Molecular Gymnastics Throughout the Viral Life Cycle. 2020. Annu Rev Virol. 2020 Jun 29. doi: 10.1146/annurev-virology-092818-015508 (TP09, TP04, TP11, TP23)

Che C Colpitts, Ridewood S., Schneiderman B., Warne J., Tabata K., Caitlin F Ng, Bartenschlager R, Selwood DL, Towers. GJ 2020. Hepatitis C virus exploits cyclophilin A to evade PKR. eLife. 2020; 9: e52237. doi: 10.7554/eLife.52237 (TP09)

Stanifer ML, Kee C, Cortese M, Zumaran CM, Triana S, Mukenhirn M, Kraeusslich HG, Alexandrov T, Bartenschlager R, Boulant S. 2020. Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells. Cell Rep. 2020 Jul 7;32(1):107863. doi: 10.1016/j.celrep.2020.107863 (TP09, TP22)

Stubbe M, Mai J, Paulus C, Stubbe H.C, Berscheminski J, Karimi M, Hofmann S, Weber E, Hadian K, Hay R, Groitl P, Nevels M, Dobner T, Schreiner S 2020. Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers. mBio, 11(2), e00049-20. https://doi.org/10.1128/mBio.00049-20 (TP19)

Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A. 2020. Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. 2020 May 20:S1074-7613(20)30182-5. doi: 10.1016/j.immuni.2020.05.001. (TP07)

Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJ, Boldanova T, Zhang Y, Brueggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E. 2020. C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol. 2020 Apr 12. pii: S0168-8278(20)30209-9. doi: 10.1016/j.jhep.2020.03.047. (TP09)

Dao Thi VL, Wu X, Belote RL, Andreo U, Takacs CN, Fernandez JP, Vale-Silva LA, Prallet S, Decker CC, Fu RM, Qu B, Uryu K, Molina H, Saeed M, Steinmann E, Urban S, Singaraja RR, Schneider WM, Simon SM, Rice CM. Stem cell-derived polarized hepatocytes. Nat Commun. 2020 Apr 3;11(1):1677. doi: 10.1038/s41467-020-15337-2.

Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B. 2020. Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nat Immunol. 21(5):555-566. (TP05, TP06)

Andrä I, Ulrich H, Dürr S, Soll D, Henkel L, Angerpointner C, Ritter J, Przibilla S, Stadler H, Effenberger M, Busch DH, Schiemann M. 2020. An Evaluation of T-Cell Functionality After Flow Cytometry Sorting Revealed p38 MAPK Activation. Cytometry A. 97(2):171-183. doi: 10.1002/cyto.a.23964. (Z02)

Börner K, Kienle E, Huang LY, Weinmann J, Sacher A, Bayer P, Stüllein C, Fakhiri J, Zimmermann L, Westhaus A, Beneke J, Beil N, Wiedtke E, Schmelas C, Miltner D, Rau A, Erfle H, Kräusslich HG, Müller M, Agbandje-McKenna M, Grimm D.Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening. Mol Ther. 2020 Feb 13. pii: S1525-0016(20)30095-2. doi: 10.1016/j.ymthe.2020.02.009. (TP18)

Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. 2020. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 72(5):960-975. (TP05, TP06, TP11, TP13, TP14)

Michler T, Kosinska AD, Festag J, Bunse T, Su J, Ringelhan M, Imhof H, Grimm D, Steiger K, Mogler C, Heikenwalder M, Michel ML, Guzman CA, Milstein S, Sepp-Lorenzino L, Knolle P, Protzer U. 2020. Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-titer HBV Carrier Mice. Gastroenterology. 158(6):1762-1775. (TP05, TP06, TP18)

Binder B, Thimme R. CD4+ T cell responses in human viral infection: lessons from hepatitis C. J Clin Invest. 2020 Feb 3;130(2):595-597. doi: 10.1172/JCI133222.

Smits M, Zoldan K, Ishaque N, Gu Z, Jechow K, Wieland D, Conrad C, Eils R, Fauvelle C, Baumert TF, Emmerich F, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Boettler T. 2020. Follicular T helper cells shape the HCV-specific CD4 T cell repertoire after viral elimination. J Clin Invest. 130(2):998-1009. (TP01, TP02, TP04, Z02)

Winkler F, Bengsch B. 2020. Use of Mass Cytometry to Profile Human T Cell Exhaustion. Front Immunol. 2020 Jan 22;10:3039. doi: 10.3389/fimmu.2019.03039.



2019

A. Hass H, Loos C, Alvarez ER, Timmer J, Hasenauer J, Kreutz C. 2019. Benchmark Problems for Dy-namic Modeling of Intracellular Processes. Bioinformatics. Bioinformatics 35: 3073-3082. (TP10)

Ackermann C, Smits M, Woost R, Eberhard JM, Peine S, Kummer S, Marget M, Kuntzen T, Kwok WW, Lohse AW, Jacobs T, Boettler T, Schulze Zur Wiesch J. 2019. HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules. Sci Rep. 9(1):10624. (TP04)

Lang J, Neumann-Haefelin C, Thimme R. Immunological cure of HBV infection. 2019. Hepatol Int. 13(2):113-124. (TP01, TP02)

Gebhardt A, Bergant V, Schnepf D, Moser M, Meiler A, Togbe D, Mackowiak C, Reinert LS, Paludan SR, Ryffel B, Stukalov A, Staeheli P, Pichlmair A. 2019. The alternative cap-binding complex is required for antiviral defense in vivo.PLoS Pathog. 2019 Dec 19;15(12):e1008155. (TP11)

Lee JS, Tabata K, Twu WI, Rahman MS, Kim HS, Yu JB, Jee MH, Bartenschlager R, Jang SK. 2019. RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection. PLoS Pathog. 2019 Sep 16;15(9):e1008021. doi: 10.1371/journal.ppat.1008021. (TP09)

Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Jühling F, Oudot MA, Virzì A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Everaert C, Jovanovic M, Mertins P, Carr SA, Chayama K, Dali-Youcef N, Ricci R, Bardeesy NM, Fujiwara N, Gevaert O, Zeisel MB, Hoshida Y, Pochet N, Baumert TF. 2019. Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development. Gastroenterology. 2019 Aug;157(2):537-551.e9. doi: 10.1053/j.gastro.2019.04.003. Epub 2019 Apr 9. (TP09)

Hu J, Protzer U, Siddiqui A. 2019. Revisiting Hepatitis B virus: Challenges of Curative Therapies. J Virol. 2019 Aug 2. pii: JVI.01032-19. doi: 10.1128/JVI.01032-19. (Epub ahead of print). Review. (TP14)

Ramadori P, Klag T, Malek NP, Heikenwalder M. 2019. Platelets in chronic liver disease, from bench to bedside. JHEP Rep. 1(6):448-459. eCollection 2019 Dec. Review. (TP06)

Faure-Dupuy S, Delphin M, Aillot L, Dimier L, Lebossé F, Fresquet J, Parent R, Sebastian Matter M, Rivoire M, Bendriss-Vermare N, Salvetti A, Heide D, Flores L, Klumpp K, Lam A, Zoulim F, Heikenwälder M, Durantel D, Lucifora J. 2019. Hepatitis B Virus-induced modulation of liver macrophage function promotes hepatocyte infection. J Hepatol. 2019 Jul 23. pii: S0168-8278(19)30422-2. doi: 10.1016/j.jhep.2019.06.032. (Epub ahead of print) (TP06)

Kosinska AD, Moeed A, Kallin N, Festag J, Su J, Steiger K, Michel ML, Protzer U, Knolle PA. 2019. Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection. Sci Rep.9(1):10808. doi: 10.1038/s41598-019-47149-w.(TP05, TP14)

Lempp FA, Schlund F, Rieble L, Nussbaum L, Link C, Zhang Z, Ni Y, Urban S. 2019. Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation. Nat Commun. 10(1):2265. doi: 10.1038/s41467-019-10211-2. (TP15)

Wing PA, Davenne T, Wettengel J, Lai AG, Zhuang X, Chakraborty A, D'Arienzo V, Kramer C, Ko C, Harris JM, Schreiner S, Higgs M, Roessler S, Parish JL, Protzer U, Balfe P, Rehwinkel J, McKeating JA. 2019. A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis. Life Sci Alliance. 2019 Mar 27;2(2). pii: e201900355. doi: 10.26508/lsa.201900355. (TP14, TP16)

Bockmann JH, Stadler D, Xia Y, Ko C, Wettengel JM, Zur Wiesch JS, Dandri M, Protzer U. 2019. Comparative analysis of the antiviral effects mediated by type I and III interferons in hepatitis B virus infected hepatocytes. J Infect Dis. 2019 Mar 29. pii: jiz143. doi: 10.1093/infdis/jiz143. (Epub ahead of print) (TP14)

Wisskirchen K, Kah J, Malo A, Asen T, Volz T, Allweiss L, Wettengel JM, Lütgehetmann M, Urban S, Bauer T, Dandri M, Protzer U. 2019. T cell receptor grafting allows virological control of Hepatitis B virus infection. J Clin Invest. 129(7):2932-2945. doi: 10.1172/JCI120228. (TP14, TP15, Z2)

Schneider A, Kurz S, Manske K, Janas M, Heikenwälder M, Misgeld T, Aichler M, Weissmann SF, Zischka H, Knolle P, Wohlleber D. 2019. Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection. Sci Rep. 9(1):8492. (TP05, TP06, TP13)

Lee JY, Cortese M, Haselmann U, Tabata K, Romero-Brey I, Funaya C, Schieber NL, Qiang Y, Bartenschlager M, Kallis S, Ritter C, Rohr K, Schwab Y, Ruggieri A, Bartenschlager R. 2019. Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment. Cell Rep. 27(12):3602-3617.e5. doi: 10.1016/j.celrep.2019.05.063. (TP09, TP12)

Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hösslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R*, Youngblood B*, Zehn D*. 2019. TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature. 571(7764):265-269. doi: 10.1038/s41586-019-1326-9. *equal contribution (TP01, TP05, TP13)

Płaszczyca A, Scaturro P, Neufeldt CJ, Cortese M, Cerikan B, Ferla S, Brancale A, Pichlmair A, Bartenschlager R. 2019. A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle. PLoS Pathog. 15(5):e1007736 (TP11)

Lohmann V, Bartenschlager R. 2019. Indelibly Stamped by Hepatitis C Virus Infection: Persistent Epigenetic Signatures Increasing Liver Cancer Risk. Gastroenterology. 156(8):2130-2133. (TO09, TP17)

Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park JW, Oh SW, Fujita T, Hou F, Binder M, Hur S. 2019. Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity. Cell. 177(5):1187-1200.e16. doi: 10.1016/j.cell.2019.03.017. (TP11)

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. 2019. Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med. 25(4):641-655. doi: 10.1038/s41591-019-0379-5. (TP05, TP06)

Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Jühling F, Oudot MA, Virzì A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Everaert C, Jovanovic M, Mertins P, Carr SA, Chayama K, Dali-Youcef N, Ricci R, Bardeesy NM, Fujiwara N, Gevaert O, Zeisel MB, Hoshida Y, Pochet N, Baumert TF. 2019. Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development. Gastroenterology 157(2):537-551.e9. doi: 10.1053/j.gastro.2019.04.003 (TP09)

Deng L, Jiang W, Wang X, Merz A, Hiet MS, Chen Y, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G. Syntenin regulates Hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes. J Hepatol. 271(1):52-61. doi: 10.1016/j.jhep.2019.03.006 (TP09)

Scaturro P, Pichlmair A. 2019. Oxeiptosis: a discreet way to respond to radicals. Curr Opin Immunol. 2019 Feb;56:37-43. doi: 10.1016/j.coi.2018.10.006. (TP11)

Hoffmann MD, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, Mastel M, Börner K, Eils R, Grimm D, Niopek D. 2019. Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic Acids Res. 47(13):e75. doi: 10.1093/nar/gkz271 (TP18, Z2)

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A. 2019. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol. 2019 Mar 4. doi: 10.1038/s41590-019-0323-3. (TP11)

Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, Flecken T, Lang J, Ehrenmann P, Emmerich F, Hofmann M, Thimme R, Neumann-Haefelin C, Boettler T. 2019. OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection. J Hepatol. 70(6):1103-1113. doi: 10.1016/j.jhep.2019.02.016 (TP01, TP02, TP04)

Karimzadeh H, Kiraithe MM, Oberhardt V, Alizei ES, Bockmann J, Zur Wiesch JS, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C. 2019. Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level. Gastroenterology. 2019 Feb 12. pii: S0016-5085(19)30366-X. doi: 10.1053/j.gastro.2019.02.003. (Epub ahead of print). (TP01, TP02, TP03, TP14)

Schuch A, Salimi Alizei E, Heim K, Wieland D, Kiraithe MM, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M, Thimme R. 2019. Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut. 2019 Jan 8. pii: gutjnl-2018-316641. doi: 10.1136/gutjnl-2018-316641. (Epub ahead of print). (TP01, TP02, TP15, TP16, A01)

Xia Y, Schlapschy M, Morath V, Roeder N, Vogt EI, Stadler D, Cheng X, Dittmer U, Sutter K, Heikenwalder M, Skerra A, Protzer U. 2019. PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice. Antiviral Res. 161:134-143. doi: 10.1016/j.antiviral.2018.11.003. (TP06, TP14)

Bartenschlager R, Urban S, Protzer U. 2019. Towards curative therapy of chronic viral hepatitis. Z Gastroenterol. 57(1):61-73. doi: 10.1055/a-0824-1576. Review. (TP09, TP14, TP15)

Gehring AJ, Protzer U. 2019. Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection. Gastroenterology. 156(2):325-337. doi: 10.1053/j.gastro.2018.10.032. (TP14)



2018

Bubeck F, Hoffmann MD, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Börner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D. 2018. Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nat Methods. 15(11):924-927. (TP18, Z02)

Velkov S, Ott JJ, Protzer U, Michler T. 2018. The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.Genes (Basel). 9(10). pii: E495. doi: 10.3390/genes9100495. (TP14)

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. 2018. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 9(1):4805. doi: 10.1038/s41467-018-07213-x. (TP05, TP13)

Luxenburger H, Neumann-Haefelin C, Thimme R, Boettler T. 2018. HCV-Specific T Cell Responses During and After Chronic HCV Infection. Viruses. 10(11). pii: E645. doi: 10.3390/v10110645. Review. (TP01, TP02, TP04)

Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M. 2018. NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection. J Hepatol. 2018 Oct 18. pii: S0168-8278(18)32458-9. doi: 10.1016/j.jhep.2018.10.006. (Epub ahead of print). (TP01. TP02, TP04, TP07)

Lazarus J, Block T, Bréchot C, Kramvis A, Miller V, Ninburg M, Penicaud MC, Protzer U, Razavi H, Thomas L, Wallace J, Cowie B. 2018. The hepatitis B epidemic and the urgent need for cure preparedness. Nature Reviews Gastroenterology and Hepatology. 15(9): 517-518. (TP14)

Lohmann V. 2018. Hepatitis C virus cell culture models: an encomium on basic research paving the road to therapy development. Med Microbiol Immunol. 2018 Oct 8. doi: 10.1007/s00430-018-0566-x. Review. (Epub ahead of print). (TP17)

Rehermann B, Thimme R. 2018. Insights From Antiviral Therapy into Immune Responses to HBV and HCV Infection. Gastroenterology. 2018 Sep 26. pii: S0016-5085(18)35037-6. doi: 10.1053/j.gastro.2018.08.061. (Epub ahead of print). (TP01)

Neumann-Haefelin C, Thimme R. 2018. Entering the spotlight: hepatitis B surface antigen-specific B cells. J Clin Invest. 128(10):4257-4259. Review. (TP01, TP02)

Qu B, Ni Y, Lempp FA, Vondran FWR, Urban S. 2018. T5 exonuclease hydrolysis of Hepatitis B Virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR. J Virol. 2018 Sep 19. pii: JVI.01117-18. doi: 10.1128/JVI.01117-18. (Epub ahead of print) (TP15)

Schmelas C, Grimm D. 2018. Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology. Biotechnol J. 13(9):e1700432. doi: 10.1002/biot.201700432. Review. (TP18)

Herrmann AK, Grimm D. 2018. High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious. J Mol Biol. 430(17):2626-2640. doi: 10.1016/j.jmb.2018.05.022. Review. (TP18)

Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D. 2018. AAVvector-mediated in vivo reprogramming into pluripotency.Nat Commun. 9(1):2651. doi: 10.1038/s41467-018-05059-x. (TP18)

Tu T, Budzinska MA, Vondran FWR, Shackel NA, Urban S. 2018. Hepatitis B virus DNA integration occurs early in the viral life cycle in an in vitro infection model via NTCP-dependent uptake of enveloped virus particles. J Virol. 2018 Feb 7. pii: JVI.02007-17. doi: 10.1128/JVI.02007-17. (Epub ahead of print) (TP15)

Tu T, Urban S. 2018. Virus entry and its inhibition to prevent and treat hepatitis B and hepatitis D virus infections. Curr Opin Virol. 30:68-79. doi: 10.1016/j.coviro.2018.04.004.Review. (TP15)

Budzinska MA, Shackel NA, Urban S, Tu T. 2018. Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion. Emerg Microbes Infect. 7(1):142. doi: 10.1038/s41426-018-0145-7. (TP15)

Budzinska MA, Shackel NA, Urban S, Tu T. 2018. Cellular Genomic Sites of Hepatitis B Virus DNA Integration. Genes (Basel). 9(7). pii: E365. doi: 10.3390/genes9070365. Review. (TP15)

Müncheberg S, Hay TR, Ip HW., Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S. 2018. E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression. J Virol. 92(13).pii: e00164-18. doi: 10.1128/JVI.00164-18. (TP16)

Inturi R., Mun K., Singethan K., Schreiner S, Punga T. 2018. Human Adenovirus Infection Counteracts Antiviral Activity of the celllar MKRN1 E3 Ubiquitin Ligase. J Virol. 17;92(3). pii: e01154-17. doi: 10.1128/JVI.01154-17. (TP16)

Freudenberger N., Hay R. T., Groitl P., Dobner T., Schreiner S, 2018. HAdV pV core protein is targeted by the host SUMOylation machinery to pursue essential viral functions. J Virol. 92(4). pii: e01451-17. doi: 10.1128/JVI.01451-17. (TP16)

Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. 2018. Hepatitis B virus (HBV) genome recycling and de novo secondary infection events maintain stable cccDNA levels. J Hepatol. 2018 Aug 21. pii: S0168-8278(18)32294-3. doi: 10.1016/j.jhep.2018.08.012. (Epub ahead of print) (TP14)

Schiwon M, Ehrke-Schulz E, Oswald A, Bergmann T, Michler T, Protzer U, Ehrhardt A. 2018. One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors. Mol Ther Nucleic Acids. 12:242-253. doi: 10.1016/j.omtn.2018.05.006. (TP18)

Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G, Pichlmair A. 2018. Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity. PLoS Pathog 14(4):e1006980. doi: 10.1371/journal.ppat.1006980. eCollection 2018 Apr. (TP11)

Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A. 2018. An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 Sep 3. doi: 10.1038/s41586-018-0484-5. (Epub ahead of print) (TP09, TP11)

Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T. 2018. microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology. 2018 Aug 27. pii: S0016-5085(18)34918-7. doi: 10.1053/j.gastro.2018.08.032. (Epub ahead of print) (TP6)

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D. 2018. Outcome of anti-viral immunity in the liver is shaped by the level of antigen expressed in infected hepatocytes. Hepatology. 2018 May 5. doi: 10.1002/hep.30080. (TP01, TP14, TP13, TP15; Bengsch associated) (Epub ahead of print)

Nassal M. 2018. Chronic hepatitis B: divide and conquer? Gut. 67(3):400-402. doi: 10.1136/gutjnl-2017-314255. (TP16)

Dembek C, Protzer U, Roggendorf M. 2018. Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination. Curr Opin Virol. 30:58-67. doi: 10.1016/j.coviro.2018.04.003. Review. (TP14)

Esser K, Lucifora J, Wettengel J, Singethan K, Glinzer A, Zerneke A, Protzer U. 2018. Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle. Antiviral
Research 151: 4-7. (TP14)

Luxenburger H, Graß F, Baermann J, Boettler T, Marget M, Emmerich F, Panning M, Thimme R, Nitschke K, Neumann-Haefelin C. Differential virus-specific CD8+ T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4. J Viral Hepat 2018, Jul;25(7):779-790. doi: 10.1111/jvh.12874. (TP01, TP02, TP04)

Hofmann M, Wieland D, Pircher H, Thimme R. 2018. Memory vs memory-like: The different facets of CD8+ T-cell memory in HCV infection.Immunol Rev. 283(1):232-237. doi: 10.1111/imr.12642. (TP01)

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M. 2018. Amino acid substitutions within HLA-B*27-restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8+ T cells. J Virol. 92(13). pii: e01891-17. doi: 10.1128/JVI.01891-17. (TP01, TP02, TP03, TP14)

Provine NM, Binder B, FitzPatrick MEB, Schuch A, Garner LC, Williamson KD, van Wilgenburg B, Thimme R, Klenerman P, Hofmann M. Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells. Front Immunol. 2018 Apr 23;9:756. doi: 10.3389/fimmu.2018.00756. eCollection 2018. (TP01)

Groepper C, Rufinatscha K, Schröder N, Stindt S, Ehlting C, Albrecht U, Bock HH, Bartenschlager R, Häussinger D, Bode JG. 2018. HCV modifies EGF signalling and upregulates production of CXCR2 ligands: role in inflammation and antiviral immune response. J Hepatol. 69(3):594-602. doi: 10.1016/j.jhep.2018.04.005 (TP09)

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V. 2018. Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes. Gastroenterology. 154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020. (TP01, TP02, TP09, TP11, TP17)

Zhang Z, Filzmayer C, Ni Y, Sültmann H, Mutz P, Hiet MS, Vondran FWR, Bartenschlager R, Urban S. 2018. Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes. J Hepatol. 69(1):25-35. doi: 10.1016/j.jhep.2018.02.021 (TP09, TP15)

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M. 2018. Single cell polarity in liquid phase facilitates tumour metastasis. Nat Commun. 9(1):887. doi: 10.1038/s41467-018-03139-6. (TP06, TP14)

Neufeldt CJ, Cortese M, Acosta EG, Bartenschlager R. 2018. Rewiring cellular networks by members of the Flaviviridae family. Nat Rev Microbiol.16(3):125-142. doi: 10.1038/nrmicro.2017.170. (TP09)

Mutz P, Metz P, Lempp FA, Bender S, Qu B, Schöneweis K, Seitz S, Tu T, Restuccia A, Frankish J, Dächert C, Schusser B, Koschny R, Polychronidis G, Schemmer P, Hoffmann K, Baumert TF, Binder M, Urban S, Bartenschlager R. 2018. HBV Bypasses the Innate Immune Response and Does not Protect HCV From Antiviral Activity of Interferon. Gastroenterology. 154(6):1791-1804.e22. doi: 10.1053/j.gastro.2018.01.044. (TP09, TP11, TP15).

Luxenburger H, Graß F, Baermann J, Boettler T, Marget M, Emmerich F, Panning M, Thimme R, Nitschke K, Neumann-Haefelin C. Differential virus-specific CD8(+) T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4. J Viral Hepat. 2018 Feb 3. doi: 10.1111/jvh.12874. (Epub ahead of print) PubMed PMID: 29397015. (TP01, TP02, TP04)

Utzschneider DT, Delpoux A, Wieland D, Huang X, Lai CY, Hofmann M, Thimme R, Hedrick SM. 2018. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep. 22(13):3454-3467. (TP01)

Boettler T, Thimme R. 2018. Lost in Inflammation: The Functional Conversion of Regulatory T Cells in Acute Hepatitis A Virus Infection. Gastroenterology. 154(4):798-800. doi: 10.1053/j.gastro.2018.02.003. (TP01, TP04)

Holze C, Michaudel C, Mackowiak C, Haas D. A, Benda C, Hubel P, Pennemann F. L, Schnepf, D, Wettmarshausen J, Braun M, Leung D.W, Amarasinghe G. K, Perocchi F, Staeheli P, Ryffel B, Pichlmair A. 2018. Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.Nature Immunology V19, pages130–140 doi:10.1038/s41590-017-0013-y (TP11)

Schmelas, C, Grimm D. 2018. Split Cas9, not hairs - advancing the therapeutic index of CRISPR technology.Biotechnol J. 2018 Jan 5. doi: 10.1002/biot.201700432. (Epub ahead of print) (TP18)

Ringelhan M, Pfister D, O'Connor T, Pikarsky E, Heikenwalder M. 2018.
The immunology of hepatocellular carcinoma. Nature Immunology. 19(3):222-232. (TP06)

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A. 2018. Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis. J Hepatol. 68(3):421-430. (TP01, TP07, TP09, TP17)



2017

Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs J, Bartenschlager R. 2017. Deciphering the origin and evolution of hepatitis B viruses by means of a family of nonenveloped fish viruses. Cell Host & Microbe. 22(3):387-399.e6. doi: 10.1016/j.chom.2017.07.019. (TP09)

Klöss V, Grünvogel O, Wabnitz G, Eigenbrod T, Ehrhardt S, Lasitschka F,Lohmann V, Dalpke AH. 2017. Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells. Front Immunol. 8:1238. doi: 10.3389/fimmu.2017.01238. eCollection 2017. (TP17)

Li Y, Xia Y, Han M, Chen G, Zhang D, Thasler W, Protzer U, Ning Q. 2017. IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection. Scientific Reports 7(1):12715. doi: 10.1038/s41598-017-13082-z. (TP14)

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R. 2017. Host-directed therapies for bacterial and viral infections. Nat Rev Drug Discov. 2017 Sep 22. doi: 10.1038/nrd.2017.162

P Lucarelli, M Schilling, C Kreutz, A Vlasov, ME Boehm, N Iwamoto, B Steiert, S Lattermann, M Wäsch, M Stepath, MS Matter, M Heikenwälder, K Hoffmann, D Deharde, G Damm, D Seehofer, M Muciek, N Gretz, WD Lehmann, J Timmer, U Klingmüller. 2017. Resolving the Combinatorial Complexity of Smad Protein Complex Formation and the Link to Gene Expression. Cell Systems, accepted (TP06, TP10).

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U. 2017. Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017. (TP10)

Lempp FA, Urban S. 2017. Hepatitis Delta Virus: Replication Strategy and Upcoming Therapeutic Options for a Neglected Human Pathogen. Viruses. 9(7). pii: E172. doi: 10.3390/v9070172. Review. (TP15)

Nassal M. 2017. Chronic hepatitis B: divide and conquer? Gut. 2017 Jul 13. pii: gutjnl-2017-314255. doi: 10.1136/gutjnl-2017-314255. (Epub ahead of print) (TP16)

Levander S, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, Bartenschlager R, Sällberg M. Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model. Gut. 2017 Jun 23. pii: gutjnl-2016-313579. doi: 10.1136/gutjnl-2016-313579. (Epub ahead of print). (TP09)

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017 Jun 12;31(6):771-789.e6. (TP05. TP06. TP13)

Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M. 2017. Phosphorylation of serine 225 in hepatitis C virus NS5A regulates protein-protein interactions. J Virol. 2017 Jun 14. pii: JVI.00805-17. doi: 10.1128/JVI.00805-17. (Epub ahead of print) (TP11)

Schreiner S, Nassal M. 2017. A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond? Viruses. 9(5). pii: E125. doi: 10.3390/v9050125. Review. (TP16)

Protzer U. 2017. Viral hepatitis: The bumpy road to animal models for HBV infection. Nat Rev Gastroenterol Hepatol. 14(6):327-328. Review (TP14, TP18)

Pollmann J, Rölle A, Hofmann M, Cerwenka A. 2017. Hepatitis C Virus and Human Cytomegalovirus-Natural Killer Cell Subsets in Persistent Viral Infections. Front Immunol. 8:566. Review (TP01, TP07)

Tu T, Bühler S, Bartenschlager R. Chronic viral hepatitis and its association with liver cancer. Biol Chem. 2017 Apr 29. pii: /j/bchm.just-accepted/hsz-2017-0118/hsz-2017-0118.xml. doi: 10.1515/hsz-2017-0118. (TP09)

Ko C, Michler T, Protzer U. Novel viral and host targets to cure hepatitis B. Curr Opin Virol. 2017 Apr 20;24:38-45. Review. (TP14)

Tu T, Budzinska MA, Shackel NA, Urban S. 2017. HBV DNA Integration: Molecular Mechanisms and Clinical Implications. Viruses. 9(4). pii: E75. doi: 10.3390/v9040075. Review. (TP15)

Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S. Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Hepatology. 2017 Feb 13. doi: 10.1002/hep.29112. (TP15, TP18)

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JM, Steinmann E. 2017. Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A. 114(12):E2430-E2439. doi: 10.1073/pnas.1619380114. (TP09)

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R. TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050. (TP01, TP02, TP05)

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M. Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Mol Cell. 2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021. (TP09, TP11, TP17)

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A. Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. MBio. 2017 Jan 10;8(1). pii: e02150-16. doi: 10.1128/mBio.02150-16. (TP09, TP12, TP17)

Golsaz-Shirazi F, Amiri MM, Farid S, Bahadori M, Bohne F, Altstetter S, Wolff L, Kazemi T, Khoshnoodi J, Hojjat-Farsangi M, Chudy M, Jeddi-Tehrani M, Protzer U, Shokri F. 2017. Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg). Antiviral Res. 144:153-163. (TP14)

Xia Y, Protzer U. Control of Hepatitis B Virus by Cytokines. Viruses. 2017 Jan 20;9(1). pii: E18. doi: 10.3390/v9010018. Review. (TP14, TP18)

Burwitz B, Wettengel J, Mück-Häusl M, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Reed N, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U**, Sacha J**. 2017. Hepatocytic Expression of Human Sodium-Taurocholate Cotransporting Polypeptide Enables Hepatitis B Virus Infection of Macaques. Nature Communications 8 (1): 2146. **co-corresponding authors. (TP14)




2016

Wohlleber D, Knolle PA. The role of liver sinusoidal cells in local hepatic immune surveillance. Clin Transl Immunology. 2016 Dec 9;5(12):e117. doi: 10.1038/cti.2016.74. Review. (TP05, TP08, TP13)

Pikarsky E, Heikenwalder M. 2016. Focal and Local: Ectopic Lymphoid Structures and Aggregates of Myeloid and Other Immune Cells in Liver. Gastroenterology. 151(5):780-783. doi: 10.1053/j.gastro.2016.09.029. (TP06)

Protzer U, Knolle P. "To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B. Gastroenterology. 2016 Nov;151(5):805-806. doi: 10.1053/j.gastro.2016.09.038 (TP05, TP08, TP14, TP18)

Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwalder M, Protzer U, Grimm D. Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO Mol Med. 2016 Sep 1;8(9):1082-98. doi: 10.15252/emmm.201506172. (TP06, TP14, TP18)

Hofmann M, Thimme R. MAIT be different-persisting dysfunction after DAA-mediated clearance of chronic hepatitis C virus infection. Eur J Immunol. 2016 Sep;46(9):2099-102. doi: 10.1002/eji.201646581. (TP01)

Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch MP, Schmidt F, Theis FJ, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 2017 Jan 9;45(1):e3. doi: 10.1093/nar/gkw805. (TP09, TP18, Z2)