Scientific Vita

Prof. Dr.

Hartmut Hengel

Academic Education and University Degrees

Habilitation in Virology, University of Munich, Germany,
MD, University of Ulm, Germany supervised by Prof. Dr. Hermann Wagner, Institute of Microbiology, Department of Immunology
Medical license
1981 - 1987
Study of Medicine at Ulm University, Germany


Since 11/2012
Full professor and Director of the Institute of Virology, Albert-Ludwigs- University Freiburg, Germany
2004 - 2012
Full professor and Director of the Institute of Virology, Heinrich-Heine University Düsseldorf, Germany
Director and Professor at Robert Koch-Institute, Berlin, Germany
Chairperson of the study group „Immunobiology of Viral Infections“ of the "Gesellschaft für Virologie" (GfV)
Acting director, Department Infectious Diseases, Robert Koch-Institute Berlin, Germany
Teaching license in the field of Virology, Freie Universität Berlin, Germany
2000 - 2004
Director, Division of viral infections, Robert Koch-Institute Berlin, Germany
1996 - 1999
Group leader at the Gene Center, Ludwig-Maximilians-University Munich and at the Virology chair of Max von Pettenkofer Institute of LMU Munich, Germany (Prof. Dr. Ulrich H. Koszinowski)
Training in Hospital and Environment Hygiene, Department of Hygiene and Med. Microbiology, Hygiene Institute, Heidelberg University, Germany (Prof. Dr. H.-G. Sonntag)
1994 - 1995
Training in pediatrics, university pediatric clinic Heidelberg, Germany (Prof. Dr. Hans Joachim Bremer)
1993 - 1996
Scientist, Hygiene-Institute of Ruprecht-Karls-University Heidelberg, Department of Virology, Germany (Prof. Dr. Ulrich H. Koszinowski)
Guest Scientist, University of Leiden, The Netherlands, Department of Immunohematology and Blood Bank (Dr. E. Goulmy)
1990 - 1993
University of Ulm, Germany, Institute of Microbiology, Department of Virology (Prof. Dr. Ulrich H. Koszinowski)
1. Hengel H, Koopmann JO, Flohr T, Muranyi W, Goulmy E, Hämmerling GJ, Koszinowski UH, Momburg F. (1997) A viral ER resident glycoprotein inactivates the MHC encoded peptide transporter. Immunity. 6:623–32. doi: 10.1016/s1074-7613(00)80350-7.
2. Atalay R, Zimmermann A, Wagner M, Borst E, Benz C, Messerle M, Hengel H. (2002) Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcγ-receptor homologs. J Virol. 76:8596–608. doi: 10.1128/jvi.76.17.8596-8608.2002.
3. Zimmermann A, Trilling M, Wagner M, Bubic I, Wilborn M, Jonjic S, Koszinowski UH, Hengel H. (2005) A viral protein reveals a dual role for STAT2 in IFN-γ signaling and antiviral responses. J Exp Med. 201:1543–53. doi: 10.1084/jem.20041401.
4. Lenac T, Budt M, Arapovic J, Hasan M, Zimmermann A, Simic H, Krmpotic A, Messerle M, Ruzsics Z, Koszinowski UH, Hengel H, Jonjic S. (2006) The herpesviral Fc receptor fcr-1 as a potent down-regulator of the NKG2D ligands MULT-1 and H60. J Exp Med. 203:1843–50. doi: 10.1084/jem.20060514.
5. Stern-Ginossar N, Elefant N, Zimmermann A, Wolf DG, Saleh N, Biton M, Horwitz E, Prokocimer Z, Prichard M, Goldman-Wohl D, Greenfield C, Yagel S, Hengel H, Altuvia Y, Margalit H, Mandelboim O. (2007) Host immune system gene targeting by a viral miRNA. Science. 317:376–81. doi: 10.1126/science.1140956.
6. Stern-Ginossar N, Weisburd B, Michalski A, Le VTK, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS. (2012) Decoding human cytomegalovirus. Science. 338:1088–93. doi: 10.1126/science.1227919.
7. Corrales-Aguilar E, Trilling M, Reinhard H, Mercé-Maldonado E, Widera M, Schaal H, Zimmermann A, Mandelboim O, Hengel H. (2013) A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors. J Immunol Methods. 387:21–35. doi: 10.1016/j.jim.2012.09.006
8. Corrales-Aguilar E, Trilling M, Hunold K, Fiedler M, Le VTK, Reinhard H, Ehrhardt K, Mercé-Maldonado E, Alijev E, Zimmermann A, Johnson DC, Hengel H. (2014) Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. PLoS Pathog. 10(5):e1004131. doi: 10.1371/journal.ppat.1004131.
9. Rölle A, Pollmann J, Ewen E-M, Halenius A, Hengel H, Cerwenka A. (2014) CD14+cells, IL-12 and HLA-E drive NKG2C+NK cell expansion in HCMV infection. J Clin Invest. 124:5305–16. doi: 10.1172/JCI77440.
10. Kolb P, Hoffmann K, Sievert A, Reinhard H, Merce-Maldonado E, Le-Trilling VTK, Halenius A, Gütle D, Hengel H. (2021) Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation. Elife. 10:e63877. doi: 10.7554/eLife.63877.
Institute of Virology
University Medical Center Freiburg Hermann-Herder-Strasse 11
79104 Freiburg