Scientific Vita

Prof. Dr.

Robert Thimme

Academic Education and University Degrees

Certificate Endocrinology
Habilitation in Internal Medicine, mentor Prof. Hubert E. Blum , University Hospital Freiburg, Germany
Certificate Gastroenterology
Certificate Gastroenterologic Oncology, DGVS
1998 - 2001
Postdoctoral fellowship at the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
1993 - 1994
Dissertation in the department of Virology, Albert-Ludwigs University of Freiburg, Germany grade: summa cum laude; supervised by Prof. Dr. Otto Haller
3. State Examination, Graduation in Human Medicine, Grade: summa cum laude
1991 - 1996
Study of Medicine at Albert-Ludwigs University of Freiburg, Germany
1989 - 1991
Study of Medicine at Free University of Berlin, Germany

Since 2013
Medical Director, Department of Internal Medicine II
2012 - 2013
Assistant Medical Director, Department of Internal Medicine II
2009 - 2013
Head of the newly founded Liver Centre of Freiburg, Germany
2009 -
Heisenberg Professorship W2 / W3 in Hepatology
2007 - 2013
Leading attending at Department of Internal Medicine II, University of Freiburg, Germany
2005 - 2009
Junior Professorship for Hepatitis Viral Infection
2001 - 2005
Special training in Gastroenterology at Department of Internal Medicine II, University of Freiburg, Germany
1996 - 1998
Medical Doctor at Department of Internal Medicine II, University of Freiburg, Germany
Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R. 2015. HBV-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro. J Virol 89:7433
Martin B, Hennecke N, Lohmann V, Kayser A, Neumann-Haefelin C, Kukolj G, Böcher WO, Thimme R. 2014. Restoration of HCV-specific CD8+ T-cell function by Interferon-free therapy. J Hepatol 61:538-43
Flecken T, Schmidt N, Hild S, Gostick E, Drognitz O, Zeiser R, Schemmer P, Bruns H, Eiermann T, Price DA, Blum HE, Neumann-Haefelin C, Thimme R. 2014. Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma. Hepatology 59:1415-26.
Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R. 2013. Factors that determine the antiviral efficacy of HCV-specific CD8+ T cells ex vivo. Gastroenterology 144: 426- 36.
Bengsch B, Seigel B, Flecken T, Wolanski J, Blum HE, Thimme R. 2012. Human Th17 cells express high levels of enzymatically active Dipeptidylpeptidase IV (CD26). J Immunol 188:5438- 47.
Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. 2010. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 6: e1000947.
Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R*, Thimme R*. 2009. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest 119: 376-86. * co-corresponding authors
Jo J, Aichele U, Kersting N, Klein R, Aichele P, Bisse E, Sewell AK, Blum HE, Bartenschlager R, Lohmann V, Thimme R. 2009. Analysis of CD8+ T cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology 136:1391-401.
Thimme R, Bukh J, Spangenberg HC, Wieland S, Pemberton J, Steiger C, Govindarajan S, Purcell RH, Chisari FV. 2002. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci U S A 99: 15661-8.
Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. 2001. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194: 1395-406.
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg, Germany