Scientific Vita
Publi­cations
Con­tact

Dr.

Marco Binder

Academic Education and University Degree
2003 - 2007
Ph.D. thesis, Molecular Virology, Department of Infectious Diseases, Heidelberg University, Germany (highest grade: summa cum laude); supervised by Dr. Volker Lohmann / Prof. Ralf Bartenschlager
2001 - 2002
Diploma work, Biology, Stony Brook University (MCB program, Prof. Eckard Wimmer), New York, USA and University of Constance; Germany, supervised Prof. Patrick Hearing and Prof. Rolf Knippers (highest grade “sehr gut”)
1998 - 2003
Study of Biology at University of Constance, Germany

Employment
Since 2014
Independent group leader, division “Virus-associated carcinogenesis”, German Cancer Research Center Heidelberg, Germany
2011 - 2014
Research group leader, Dept. for Infectious Diseases, Heidelberg University, Germany
2009 - 2010
Postdoctoral Fellowship of the Medical Faculty Heidelberg, Germany associated with the Dept. for Infectious Diseases
2007 - 2008
Postdoc, Dept. Infectious Diseases, Heidelberg University, Germany
1. Colasanti O, Burm R, Huang H-E, Riedl T, Traut J, Gillich N, Li T-F, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee J-Y, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. (2023) Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation. J Hepatol. 28;S0168-8278(23)00309-4 doi: 10.1016/j.jhep.2023.04.023.
2. Gillich N, Zhang Z, Binder M, Urban S, Bartenschlager R. (2023) Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication. J Hepatol. 78(1):78-89. doi: 10.1016/j.jhep.2022.08.041.
3. Zander DY, Burkart SS, Wüst S, Magalhães VG, Binder M. (2022) Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death. Cell Death Dis. 13(4):364. doi: 10.1038/s41419-022-04797-7.
4. Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M*, Trump S*, Eils R*, Mall MA*, Lehmann I*. (2022) Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol. 40(3):319–324. doi: 10.1038/s41587-021-01037-9.
5. Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A. (2021) NUDT2 initiates viral RNA degradation by removal of 5′-phosphates. Nat Commun. 12(1):6918. doi: 10.1038/s41467-021-27239-y.
6. Urban C, Welsch H, Heine K, Wüst S, Haas DA, Dächert C, Pandey A, Pichlmair A*, Binder M*. (2021) Persistent innate immune stimulation results in IRF3-mediated but caspase-independent cytostasis. Viruses. 12(6):635. doi: 10.3390/v12060635.
7. Trump S*, Lukassen S*, Anker MS*, Chua RL*, Liebig J*, Thürmann L*, Corman VM*, Binder M*, Loske J, Klasa C, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Völker MT, Müller SD, Liebert UG, Ishaque N, Kaderali L, Sander L-E, Drosten C, Laudi S, Eils R, Conrad C, Landmesser U, Lehmann I. (2020) Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19. Nat Biotechnol. 39(6):1–12. doi: 10.1038/s41587-020-00796-1.
8. Kok F, Rosenblatt M, Teusel M, Nizharadze T, Magalhães VG, Dächert C, Maiwald T, Vlasov A, Wäsch M, Tyufekchieva S, Hoffmann K, Damm G, Seehofer D, Boettler T, Binder M, Timmer J, Schilling M, Klingmüller U. (2020) Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction. Mol Syst Biol. 16(7):e8955. doi: 10.15252/msb.20198955.
9. Namineni S, O’Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U,Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. (2020) A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 72(5):960–975. doi: 10.1016/j.jhep.2019.12.019.
10. Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M. (2017) Phosphorylation-dependent feedback inhibition of RIG-I by DAPK1 identified by kinome-wide siRNA screening. Mol Cell. 65(3):403-415.e8. doi 10.1016/j.molcel.2016.12.021.
Address
Division Virus-associated carcinogenesis (F170)
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
eMail
m.binder@dkfz.de