Research group leader, Molecular Virology, University Heidelberg
Scientific Vita
Publications
Contact
Dr.
Stefan Seitz
Professional career
Since 2020
Since 2011
Research Associate in the group of Prof. Dr. Ralf Bartenschlager, Dept. of Infectious Diseases, Molecular Virology, University Heidelberg.
2002 - 2010
Research Associate in the group of Prof. Dr. Stephan Urban, Dept. of Infectious Diseases, Molecular Virology, University Heidelberg.
University training and degree
1999
3rd State Examination in Medicine
1995 - 1997
Study of Molecular Biology, Center for Molecular Biology, Heidelberg, supervised by Prof. Dr. Heinz Schaller
1991 - 1999
Study of Medicine at University Erlangen, Heidelberg and Mannheim
1. Harati Taji Z, Bielytskyi P, Shein M, Sani MA, Seitz S*, Schütz AK*. (2022) Transient RNA interactions leave a covalent imprint on a viral capsid protein. J Am Chem Soc. 144:8536-8550. DOI: 10.1021/jacs.1c12439. *co-corresponding authors.2. Seitz S, Habjanič J, Schütz AK, Bartenschlager R. (2020) The hepatitis B virus envelope proteins: molecular gymnastics throughout the viral life cycle. Annu Rev Virol. 7:263-288. DOI: 10.1146/annurev-virology-092818-015508.3. Lauber C*, Seitz S*,**, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs JAG, Bartenschlager R. (2017) Deciphering the origin and evolution of hepatitis B viruses by means of a family of non-enveloped fish viruses. Cell Host Microbe. 22:387-399. DOI: 10.1016/j.chom.2017.07.019. *equal contribution, **corresponding author.4. Seitz S, Iancu C, Volz T, Mier W, Dandri M, Urban S, Bartenschlager R. (2016) A slow maturation process renders hepatitis B virus infectious. Cell Host Microbe. 20:25-35. DOI: 10.1016/j.chom.2016.05.013. 5. Seitz S, Urban S, Antoni C, Böttcher B. (2007) Cryo-electron microscopy of hepatitis B virions reveals variability in envelope capsid interactions. EMBO J. 26:4160-4167. DOI: 10.1038/sj.emboj.7601841.6. Pfister S, Rabl J, Wiegand T, Mattei S, Malär AA, Lecoq L, Seitz S, Bartenschlager R, Böckmann A, Nassal M, Boehringer D, Meier BH. (2023) Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style. Nat Commun. 14:1574. DOI: 10.1038/s41467-023-37068-w.7. Petersen J, Dandri M, Mier W, Lütgehetmann M, Volz T, von Weizsäcker F, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S. (2008) Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol. 26:335-341. DOI: 10.1038/nbt1389.8. Mutz P, Metz P, Lempp FA, Bender S, Qu B, Schöneweis K, Seitz S, Tu T, Restuccia A, Frankish J, Dächert C, Schusser B, Koschny R, Polychronidis G, Schemmer P, Hoffmann K, Baumert TF, Binder M, Urban S, Bartenschlager R. (2018) HBV bypasses the innate immune response and does not protect HCV from antiviral activity of interferon. Gastroenterology. 154:1791-1804. DOI: 10.1053/j.gastro.2018.01.044.9. Corcuera A, Stolle K, Hillmer S, Seitz S, Lee JY, Bartenschlager R, Birkmann A, Urban A. (2018) Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro. Antiviral Res. 158:135-142. DOI: 10.1016/j.antiviral.2018.07.011.10. Binder M, Eberle F, Seitz S, Mücke N, Hüber CM, Kiani N, Kaderali L, Lohmann V, Dalpke A, Bartenschlager R. (2011) Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem. 286:27278-87. DOI: 10.1074/jbc.M111.256974.
- Address
- Department of Infectious Deseases, Molecular Virology
Medical Faculty, Heidelberg University
Im Neuenheimer Feld 344
69120 Heidelberg - stefan.seitz@med.uni-heidelberg.de