Scientific Vita

Prof (Apl) Dr.

Tobias Böttler

Academic Education and University Degrees
Habilitation in Internal Medicine, University of Freiburg (mentor: Prof. Dr. Robert Thimme)2003 - 2007
2000 - 2007
Medical School at Freiburg University, Germany

Since 2017
Attending physician at the Department of Gastroenterology and Hepatology, Freiburg University (Director: Prof. Dr. Robert Thimme)
Since 2014
Independent group leader at the Department of Gastroenterology and Hepatology, Freiburg University , Germany
Since 2012
Resident physician at the Department of Gastroenterology and Hepatology, Freiburg University, Germany headed by Prof. Dr. H. Blum/ Prof. Dr. Robert Thimme
2009 - 2012
Postdoctoral research at the La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA, supervised by Prof. Dr. Matthias von Herrath
2007 - 2009
Resident physician at the Department of Gastroenterology and Hepatology, Freiburg University, Germany headed by Prof. Dr. H. Blum
1. Wild K, Smits M, Killmer S, Strohmeier S, Neumann-Haefelin C, Bengsch B, Krammer F, Schwemmle M, Hofmann M, Thimme R, Zoldan K, Boettler T. (2021) Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination. Nat Commun. 12(1):6720. doi: 10.1038/s41467-021-27064-3.
2. Zoldan K, Ehrlich S, Killmer S, Wild K, Smits M, Russ M, Globig AM, Hofmann M, Thimme R, Boettler T. (2021) Th1-Biased hepatitis C virus-specific follicular T helper-like cells effectively support B cells after antiviral therapy. (2021) Front Immunol. 12:742061. doi: 10.3389/fimmu.2021.742061.
3. Basho K, Zoldan K, Schultheiss M, Bettinger D, Globig AM, Bengsch B, Neumann-Haefelin C, Klocperk A, Warnatz K, Hofmann M, Thimme R, Boettler T. (2021) IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis. J Hepatol. 74(3):649-660. doi: 10.1016/j.jhep.2020.10.012.
4. Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T*, Bengsch B*, Thimme R*, Hofmann M*, Neumann-Haefelin C*. (2021) Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nat Med. 27(1):78-85. doi: 10.1038/s41591-020-01143-2. *jointly supervised.
5. Smits M, Zoldan K, Ishaque N, Gu Z, Jechow K, Wieland D, Conrad C, Eils R, Fauvelle C, Baumert TF, Emmerich F, Bengsch B, Neumann-Haefelin C, Hofmann M, Thimme R, Boettler T. (2020) Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination. J Clin Invest. 130(2):998-1009. doi: 10.1172/JCI129642.
6. Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, Flecken T, Lang J, Ehrenmann P, Emmerich F, Hofmann M, Thimme R, Neumann-Haefelin C, Boettler T. (2019) OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection. J Hepatol. 70(6):1103-1113. doi: 10.1016/j.jhep.2019.02.016.
7. Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. (2016) Virus-specific CD4+ T cells have functional and phenotypic characteristics of follicular T-helper cells in patients with acute and chronic HCV infections. Gastroenterology. 150(3):696-706.e3. doi: 10.1053/j.gastro.2015.11.005.
8. Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M. (2013) Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. J Immunol. 191(10):5026-35. doi: 10.4049/jimmunol.1300013.
9. Boettler T, Panther E, Bengsch B, Nazarova N, Spangenberg HC, Blum HE, Thimme R. (2006) Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J Virol. 80(7):3532-40. doi: 10.1128/JVI.80.7.3532-3540.2006.
10. Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsäcker F, Thimme R. (2005) T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol. 79(12):7860-7. doi: 10.1128/JVI.79.12.7860-7867.2005.
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg