Scientific Vita

Prof. Dr.

Ursula Klingmüller

Academic Education and University Degrees

Venia Legendi in Cell Biology, University of Heidelberg, Germany
Habilitation and Venia Legendi in Molecular Biology and Genetics, University of Freiburg, Germany
Graduate Studies at the University of Heidelberg, Doctoral Thesis, (grade: summa cum laude) supervised by Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg (ZMBH), Germany,
Diploma in Molecular Biology, Cell Biology and Virology, University of Heidelberg, Germany, Diploma Thesis, supervised by Prof. Dr. Heinz Schaller, Center for Molecular Biology Heidelberg (ZMBH), Germany, (with distinction)
Bachelor of Science, University of Bayreuth, Germany (with distinction, November 1985)
High School Diploma, Bayreuth, Germany


Since 2011
W3 Professor, Heidelberg University, Germany
Since 2007
Head of the Division “Systems Biology of Signal Transduction”, German Cancer Research Center (DKFZ), Heidelberg, Germany
2003 - 2007
Group Leader of the Theodor Boveri-Group "Systems Biology of Signal Transduction", German Cancer Research Center (DKFZ), Heidelberg, Germany
1996 - 2003
Group Leader of an independent junior group, Hans-Spemann-Laboratories, Max-Planck-Institute Freiburg, Germany
1993 - 1996
Postdoctoral Fellow, Whitehead Institute for Biomedical Research, Group of Prof. Dr. Harvey F. Lodish, Cambridge, USA
1992 -1993
Postdoctoral Fellow, Harvard Medical School, Group of Prof. Dr. Lewis C. Cantley, Boston, USA
Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U. 2018. Resolving the combinatorial complexity of Smad protein complex formation and its link to gene expression. Cell Systems. 6(1):75-89.e11.
Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Timmer J, Schilling M, Höfer T, Klingmüller U. 2017. Protein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation. Molecular Systems Biology. 13(1):904.
Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygiel M, Müller-Decker K, Lucarelli P, Wäsch M, Mairbäurl H, Rabe KF, Kugler C, Vollmer E, Reck M, Scheufele S, Kröger M, Ammerpohl O, Siebert R, Goldmann T, Klingmüller U. 2016. Downregulation of the TGF-ß pseudoreceptor BAMBI in non-small cell lung cancer enhances TGF-ß signaling and invasion. Cancer Research. 76(13):3785-3801.
Iwamoto N, D’Alessandro LA, Depner S, Hahn B, Kramer BA, Lucarelli P, Vlasov A, Stepath M, Böhm ME, Deharde D, Damm G, Seehofer D, Lehmann WD, Klingmüller U, Schilling M. 2016. Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation. Science Signaling. 9(413):ra13.
Mueller S, Huard J, Waldow K, Huang X, D’Alessandro LA, Bohl S, Börner K, Grimm D, Klamt S, Klingmüller U, Schilling M. 2015. T160-phosphorylated CDK2 defines threshold for HGF-dependent proliferation in primary hepatocytes. Molecular Systems Biology. 11(3):795.
Bachmann J, Raue A, Schilling M, Boehm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U. 2011. Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Molecular Systems Biology. 7:516.
Raia V, Schilling M, Böhm M, Hahn B, Kowarsch A, Raue A, Sticht C, Bohl S, Saile M, Möller P, Gretz N, Timmer J, Theis F, Lehmann WD, Lichter P, Klingmüller U. Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets. Cancer Research. 71(3):693-704.
Becker V, Schilling M, Bachmann J, Baumann U, Raue A, Maiwald T, Timmer J, Klingmüller U. 2010. Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor. Science. 328(5984):1404-8.
Swameye I, Muller TG, Timmer J, Sandra O, Klingmuller U. 2003. Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based dynamic modeling. Proc. Natl. Acad. Sci. USA. 100(3):1028-33.
Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 80(5):729-738.
Division of Systems Biology of Signal Transduction
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg