Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Maike Hofmann

Academic Education and University Degrees

2007 - 2012
Ph.D. thesis, Molecular Medicine / Immunology, Institute of Immunology, Medical Center – University of Freiburg, Germany supervised by Prof. Dr. Hanspeter Pircher
2007
Diploma thesis, Molecular Medicine, Institute of Immunology, Medical Center- University of Freiburg, Germany supervised by Prof. Dr.Hanspeter Pircher
2002 - 2007
Studies in Molecular Medicine, University of Freiburg, Germany

Employment

Since 2024
Heisenberg Professor for Translational Cellular Immunology, Department of Medicine II - Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center - University of Freiburg
Since 2016
Group Leader, Department of Medicine II - Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center - University of Freiburg
Since 2014 - 2016
Scientist, Department of Medicine II - Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center - University of Freiburg, Germany
2014 - 2014
Postdoc, University spin-off cytena / Department for Microsystems Engineering, University of Freiburg, Germany
2012 - 2014
Postdoc, Institute of Immunology, Medical Center - University of Freiburg, Germany
1. Reinscheid M*, Luxenburger H*, Karl V*, Graeser A*, Giese S*, Ciminski K*, Reeg DB*, Oberhardt V, Roehlen N, Lang-Meli J, Heim K, Gross N, Baum C, Rieg S, Speer C, Emmerich F, Breisinger S, Steinmann D, Bengsch B, Boettler T, Kochs G, Schwemmle M, Thimme R*, Neumann-Haefelin C*, Hofmann M*. (2022) COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation. Nat Commun. 8;13(1):4631. doi: 10.1038/s41467-022-32324-x. *co-senior authors/co-corresponding authors.
2. Lang-Meli J, Luxenburger H, Wild K, Karl V, Oberhardt V, Salimi Alizei E, Graeser A, Reinscheid M, Roehlen N, Reeg DB, Giese S, Ciminski K, Götz V, August D, Rieg S, Waller CF, Wengenmayer T, Staudacher D, Huzly D, Bengsch B, Kochs G, Schwemmle M, Emmerich F, Boettler T, Thimme R*, Hofmann M*, Neumann-Haefelin C*. (2022) Nat Microbiol. 7:675-679. doi: 10.1038/s41564-022-01106-y. *co-corresponding authors.
3. Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MC, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Thimme R*, Neumann-Haefelin C*, Hofmann M*. (2021) Nature 597(7875), 268-273. doi: 10.1038/s41586-021-03841-4. *co-senior authors/co-corresponding authors.
4. Hensel N, Gu Z, Sagar, Wieland D, Jechow K, Kemming J, Llewellyn-Lacey S, Gostick E, Sogukpinar O, Emmerich F, Price DA, Bengsch B, Boettler T, Neumann-Haefelin C, Eils R, Conrad C, Bartenschlager R, Grün D, Ishaque N, Thimme,R*, Hofmann M*. (2021) Memory-like HCV-specific CD8(+) T cells retain a molecular scar after cure of chronic HCV infection. Nat Immunol. 229-239. doi: 10.1038/s41590-020-00817-w. *co-senior authors/co-corresponding authors.
5. Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T, Bengsch B, Thimme R*, Hofmann M*, Neumann-Haefelin C*. (2021) Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells. Nat Med. 27(1),78-85; doi:10.1038/s41591-020-01143-2. #co-senior authors/co-corresponding authors.
6. Heim K, Binder B, Sagar, Wieland D, Hensel N, Llewellyn-Lacey S, Gostick E, Price DA, Emmerich F, Vingerhoet H, Kraft ARM, Cornberg M, Boettler T, Neumann-Haefelin C, Zehn D, Bengsch B, Hofmann M*, Thimme R*. (2020) TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut 70(8),1550-1560; doi:10.1136/gutjnl-2020-322404. *co-senior authors/co-corresponding authors.
7. Schuch A, Zecher BF, Müller PA, Correia, MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M. (2019) NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection. J Hepatol. 70(3),351-360. doi:10.1016/j.jhep.2018.10.006.
8. Provine NM, Binder B, FitzPatrick MEB, Schuch A, Garner LC, Williamson KD, van Wilgenburg B, Thimme R, Klenermann P, Hofmann M. (2018) Unique and common features of innate-like human Vδ2(+) γδT cells and mucosal-associated invariant T cells. Front Immunol. 9,756. doi:10.3389/fimmu.2018.00756.
9. Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M*, Thimme R*. (2017) TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 8,15050; doi:10.1038/ncomms15050, *co-senior authors.
10. Hofmann M, Pircher H. (2011) E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands. Proc Natl Acad Sci U S A. 108(40),16741-16746; doi:10.1073/pnas.
Address
Department of Medicine II,
University Hospital Freiburg
Hugstetterstr.55
79106 Freiburg
eMail
maike.hofmann@uniklinik-freiburg.de