Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Ralf Bartenschlager

Academic Education and University Degrees

1999
Habilitation in Virology, University of Mainz, Germany; mentor: Prof. Dr. Matthias J. Reddehase
1987 - 1990
Ph.D. thesis, Molecular Biology, Center for Molecular Biology, Heidelberg, Germany, (Grade: summa cum laude) supervised by Prof. Dr. Heinz Schaller
1986 - 1987
Diploma work, Biology, Center for Molecular Biology, Heidelberg, Germany, supervised by Prof. Dr. Heinz Schaller
1981 - 1987
Study of Biology at Heidelberg University, Germany

Employment

Since 2014
Head of the Division “Virus-induced carcinogenesis”, German Cancer Research Center Heidelberg, Germany
Since 2002
Full professor (C4) for “Molecular Virology”, Heidelberg University, Germany
2000 - 2002
Full Professor for “Molecular Virology” (C3), Institute for Virology,University of Mainz, Germany
1999 - 2000
Associate professor at the Institute for Virology, University of Mainz, Germany
1994 - 1999
Independent group leader at the Institute for Virology, University of Mainz, Germany
1991 - 1993
Postdoc and leader of the HCV program “Central research Unit”, Hoffmann-LaRoche AG Basel, Switzerland
Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A*, Bartenschlager R*. 2015. Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. J Hepatol 63:829-37; *co-corresponding authors
Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R. 2012. Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 12:71-85.
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G. 2012. Viral immune modulators perturb the human molecular network by common and unique strategies. Nature 487:486-90.
Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Windisch MP, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R. 2012. Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology 56:2082-93.
Bauhofer O, Ruggieri A, Schmid B, Schirmacher P, Bartenschlager R. 2012. Persistance of HCV in Quiescent Hepatic Cells during an Interferon-Induced Antiviral Response. Gastroenterology 143:429-38
Reiss S#, Rebhan I#, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V*, Bartenschlager R*. 2011. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe 9:32-45. # equal contribution; *co-corresponding authors
Dazert E*, Neumann-Haefelin C*, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R*, Thimme R*.2009. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest 119:376-86. *co-first and -corresponding authors
Wakita, T*, Pietschmann T*, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M, Bartenschlager R*, Liang TJ. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Medicine 11:791-796. *equal contribution
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167–1172.
Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113.
Address
Department of Infectious Deseases, Molecular Virology
Medical Faculty, Heidelberg University
Im Neuenheimer Feld 345
69120 Heidelberg
eMail
ralf.bartenschlager@med.uni-heidelberg.de