Scientific Vita
Publi­cations
Con­tact

Prof. Dr. Dr. hc.

Ralf Bartenschlager

Academic Education and University Degrees
1999
Habilitation in Virology, University of Mainz, Germany; mentor: Prof. Dr. Matthias J. Reddehase
1987 - 1990
Ph.D. thesis, Molecular Biology, Center for Molecular Biology, Heidelberg, Germany, (Grade: summa cum laude) supervised by Prof. Dr. Heinz Schaller
1986 - 1987
Diploma work, Biology, Center for Molecular Biology, Heidelberg, Germany, supervised by Prof. Dr. Heinz Schaller
1981 - 1987
Study of Biology at Heidelberg University, Germany

Employment
Since 2014
Head of the Division “Virus-induced carcinogenesis”, German Cancer Research Center Heidelberg, Germany
Since 2002
Full professor (C4) for “Molecular Virology”, Heidelberg University, Germany
2000 - 2002
Full Professor for “Molecular Virology” (C3), Institute for Virology,University of Mainz, Germany
1999 - 2000
Associate professor at the Institute for Virology, University of Mainz, Germany
1994 - 1999
Independent group leader at the Institute for Virology, University of Mainz, Germany
1991 - 1993
Postdoc and leader of the HCV program “Central research Unit”, Hoffmann-LaRoche AG Basel, Switzerland
1. Gillich N, Zhang Z, Binder M, Urban S, Bartenschlager R. Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication. J Hepatol. 2023. 78(1):78-89. doi: 10.1016/j.jhep.2022.08.041
2. Lauber C*, Seitz S*, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs JAG, Bartenschlager R. 2017. Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses. Cell Host Microbe. 22:387-399. doi: 10.1016/j.chom.2017.07.019 * equal contribution
3. Seitz S, Iancu C, Volz T, Mier W, Dandri M, Urban S, Bartenschlager R. A Slow Maturation Process Renders Hepatitis B Virus Infectious. Cell Host Microbe. 2016 Jul 13;20(1):25-35. doi: 10.1016/j.chom.2016.05.013
4. Bauhofer O, Ruggieri A, Schmid B, Schirmacher P, Bartenschlager R. Persistance of HCV in Quiescent Hepatic Cells during an Interferon-Induced Antiviral Response. Gastroenterology. 2012 Aug;143(2):429-38.e8. doi: 10.1053/j.gastro.2012.04.018
5. Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe. 2011 Jan 20;9(1):32-45. doi: 10.1016/j.chom.2010.12.002.
6. Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R*, Thimme R*. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 2009 Feb 2; 119(2): 376–386. doi: 10.1172/JCI36587. *co-corresponding authors
7. Pietschmann T, Kaul A, Koutsoudakis G, Shavinskaya A, Kallis S, Steinmann E, Abid K, Negro F, Dreux M, Cosset FL, Bartenschlager R. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7408-13. doi: 10.1073/pnas.0504877103
8. Wakita, T*, Pietschmann T*, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M, Bartenschlager R*, Liang TJ. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Medicine. 2005 Jul;11(7):791-6. doi: 10.1038/nm1268 (*equal contribution)
9. Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science. 1999 Jul 2;285(5424):110-3. doi: 10.1126/science.285.5424.110
10. Bartenschlager R, Schaller H. 1992. Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome. EMBO J 1992 Sep; 11(9): 3413–3420. doi: 10.1002/j.1460-2075.1992.tb05420.x
Address
Department of Infectious Deseases, Molecular Virology
Medical Faculty, Heidelberg University
Im Neuenheimer Feld 344
69120 Heidelberg
eMail
ralf.bartenschlager@med.uni-heidelberg.de