Scientific Vita
Publi­cations
Con­tact

PD Dr.

Dirk Wohlleber

Academic Education and University Degrees

2003 - 2006
Ph.D. work, Biochemistry, Interfakultäres Institut für Biochemie, Tübingen, Germany supervised by Prof. Probst
2003 - 2003
Diploma work, Biochemistry, Interfakultäres Institut für Biochemie, Tübingen, Germany supervised by Prof. Probst
1998 - 2003
Study of Biochemistry at the University of Tübingen, Germany

Employment

2019 - today
Independent group leader at the Institute of Molecular Immunology, Technische Universität München
Since 04/2014
Research group leader at the Institute of Molecular Immunology, Technische Universität München, Germany
2006 – 2014
Postdoc at the Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Germany
1. Brugger M, Laschinger M, Lampl S, Schneider A, Manske K, Esfandyari D, Huser N, Hartmann D, Steiger K, Engelhardt S, Wohlleber D*, Knolle PA*. (2022) High precision-cut liver slice model to study cell-autonomous antiviral defense of hepatocytes within their microenvironment. JHEP Rep. 4(5):100465. doi: 10.1016/j.jhepr.2022.100465. *equal contribution.
2. Harbauer AB, Schneider A, Wohlleber D. (2022) Analysis of mitochondria by single-organelle resolution. Annu Rev Anal Chem. 15,1-16. doi: 10.1146/annurev-anchem-061020-111722.
3. Manske K, Schneider A, Ko C, Knolle PA, Steiger K, Protzer U, Wohlleber D. (2021) In vivo bioluminescence imaging of HBV replicating hepatocytes allows for the monitoring of anti-viral immunity. Viruses 13(11):2273. doi: 10.3390/v13112273.
4. Lampl S*, Janas MK*, Donakonda S*, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Klager S, Kuster B, Wettmarshausen J, Muller C, Laschinger M, Hartmann D, Huser N, Perocchi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Kronke M, Zehn D, Protzer U, Heikenwalder M, Knolle PA*, Wohlleber D*. (2020) Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. J Hepatol 73,1347-1359. doi: 10.1016/j.jhep.2020.06.026. *equal contribution
5. Schneider A, Kurz S, Manske K, Janas M, Heikenwalder M, Misgeld T, Aichler M, Weissmann S, Zischka H, Knolle PA, Wohlleber D. (2019) Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection. Sci Rep. 9:8492. doi: 10.1038/s41598-019-44922-9.
6. Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, Hösslin M, Cullen J, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen C, Thimme R*, Youngblood B*, Zehn D*. (2019) Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection. Nature 571(7764):265-269 doi: 10.1038/s41586-019-1326-9. *co-corresponding authors.
7. Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle PA*, Wohlleber D*, Kastenmüller W*. (2018) Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 9(1):4805. doi: 10.1038/s41467-018-07213-x. *equal contribution.
8. Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D. (2018) Outcome of antiviral immunity in the liver is shaped by the level of antigen expressed in infected hepatocytes. Hepatology. 68(6):2089 doi: 10.1002/hep.30080.
9. Schölzel K, Schildberg FA, Börner C, Geiger S, Kurts C, Heikenwälder M, Knolle PA, Wohlleber D. (2014) Cross-allocation of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol. 61(3):600-8 doi:10.1016/j.jhep.2014.04.028.
10. Wohlleber D*, Kashkar H*, Gärtner K*, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwälder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA. (2012) TNF-induced target cell killing by CTL activated through cross-presentation. Cell Rep. 2(3):478-487 doi: 10.1016/j.celrep.2012.08.001. *equal contribution.
Address
Institute of Molecular Immunology and Experimental Oncology
Klinikum rechts der Isar
Technische Universität München
Trogerstr. 9
81675 München
eMail
dirk.wohlleber@tum.de