Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Ulrike Protzer

Academic Education and University Degrees

2005
Board Exam „Microbiology and Virology“
2002 - 2005
Training in Medical Microbiology, University Hospital Cologne,Germany
1996
Board exam „Internal Medicine“; Clinical training, University Hospital Mainz, Germany
1992 - 1996
Clinical training, University Hospital Mainz, Germany
1990 - 1991
“Arzt im Praktikum”, MD, full approbation as clinician
1982 - 1988
Medical School, University of Erlangen, Germany

Employment

Since 11/2007
Full professor (W3) and Chair of Virology, TUM Since 11/2007 Director Institute of Virology, TUM / HMGU
2002 - 2007
Junior group leader “Molecular Infectiology” at the Center for Molecular Medicine Cologne, Germany
1996- 2000
Postdoctoral scientist, Center of Molecular Biology Heidelberg, Germany Department “Virus – host interaction of hepatitis B virus” (H. Schaller)
Xia Y*, Stadler D*, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chao W-M, Wettengel J, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Thasler WE, Heikenwalder M, Protzer U. 2015. Interferon-γ and Tumor Necrosis Factor-α Produced by T cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology, 2015 Sep 25. pii: S0016-5085(15)01382-7. doi: 10.1053/j.gastro.2015.09.026. [Epub ahead of print]. * equal contribution
Lucifora J*, Xia Y*, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl M, Koppensteiner H, Li Y, Makowska Z, Volz T, Remouchamps C, Chou W-M, Thasler W, Hüser N, Durantel D, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M*, Protzer U*. 2014. Specific and non-hepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343: 1121- 1128. * equal contribution
Bohne F, Londoño M-C, Benítez C, Miquel R, Martínez-Llordella M, Russo C, Ortiz C, Bonaccorsi- Riani E, Brander C, Bauer T, Protzer U, Jaeckel E, Taubert R, Forns X, Navasa M, Berenguer M, Rimola A, Lozano J-J, and Sánchez-Fueyo A. 2014. Role of HCV-induced immune responses on the establishment of operational tolerance following liver transplantation in humans. Sci Transl Med 6:242ra81.
Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U. 2013. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology 145:456-65.
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M*, Knolle PA*. 2013. Intrahepatic myeloid cell-aggregates enable local CD8+ T cell expansion and successful immunotherapy against chronic viral liver infection. Nat Immunol 14: 574-583. * co-corresponding authors
Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U. 2012. Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology 142:1447-50.
Bohne F, Chmielewski M, Ebert G, Wiegmann K, Kürschner T, Schulze A, Urban S, Krönke M, Abken H, Protzer U. 2008. T cells Redirected Against Hepatitis B Virus Surface Proteins Eliminate Infected Hepatocytes. Gastroenterology 134: 239-47.
Protzer U, Seyfried S, Quasdorff M, Sass G, Svorcova M, Webb D, Bohne F, Hösel M, Schirmacher P, Tiegs G. 2007. Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection. Gastroenterology 133: 1156-65.
Protzer U, Nassal M, Chiang PW, Kirschfink M, Schaller H. 1999. Interferon gene transfer by a novel hepatitis B virus vector efficiently suppresses wildtype-virus infection. Proc Natl Acad Sci U S A 96: 10818-10823.
Protzer U, Naumann U, Bartenschlager R, Berg T, Hopf U, Meyer zum Büschenfelde KH, Neuhaus P, Gerken G. 1998. Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation. Hepatology 27: 254-263.
Address
Institute of Virology
Technische Universität München
Trogerstr. 30
81675 München
eMail
protzer@tum.de