Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Dirk Grimm

Academic Education and University Degrees

2001 - 2007
Postdoctoral fellow / Research associate, Stanford University School of Medicine, Stanford, CA, USA, laboratory of Prof. Dr. Mark Kay
1999 - 2001
Postdoctoral fellow, Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany supervised by Dr. Jürgen Kleinschmidt
1995 - 1998
Ph.D. work, Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany (Grade: summa cum laude) supervised by Dr.Jürgen Kleinschmidt
1994 - 1994
Diploma work, Biology, German Cancer Research Center, Heidelberg, Germany supervised by Prof. Dr. Walter Pyerin
1988 - 1994
Study of Biology at Kaiserslautern & Heidelberg Universities, Germany

Employment

2017 - present
Full professor for viral vector technologies, Heidelberg University Hospital
2007 - 2017
Research group leader at the Department of Infectious Diseases/Virology and Cluster of Excellence CellNetworks
Mockenhaupt S, Grosse S, Rupp D, Bartenschlager R, Grimm D. 2015. Alleviation of off-target effects from vector-encoded shRNAs via co-delivered RNA decoys. PNAS 112:E4007-16
Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D. 2014. AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically-attenuated malarial parasites. Mol Ther 22: 2130-2141
Börner K, Niopek D, Cotugno G, Kaldenbach M, Pankert T, Willemsen J, Zhang X, Schürmann N, Mockenhaupt S, Serva A, Hiet AS, Wiedtke E, Castoldi M, Starkuviene V, Erfle H, Gilbert DF, Bartenschlager R, Boutros M, Binder M, Streetz K, Kräusslich HG, Grimm D. 2013. Robust RNAi enhancement via human Argonaute-2 over-expression from plasmids, viral vectors and cell lines. Nucleic Acids Res 41:e199
Schürmann N, Trabuco LG, Bender C, Russell RB, Grimm D. 2013. Molecular dissection of human Argonaute proteins by DNA shuffling. Nat Struct Mol Biol 20: 818-826
Gu S, Jin L, Zhang F, Huang Y, Grimm D, Rossi J, Kay MA. 2011. The thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proc Natl Acad Sci USA 108: 9208-9213
Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh S, Börner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D. 2010. Low-level shRNA cytotoxicity can contribute to MYC- induced hepatocellular carcinoma in mice. Mol Ther 18: 161-170
Grimm D, Wang L, Lee JS, Schürmann N, Gu S, Börner K, Storm TA, Kay MA. 2010. Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. J Clin Invest 120: 3106-3119
Grimm D, Lee JS, Wang L, Desai T, Akache B, Storm TA, Kay MA. 2008. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and re-targeting of adeno-associated viruses. J Virol 82: 5887-5911
Grimm D, Streetz KS, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA. 2006. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441: 537-541
Grimm D, Zhou S, Nakai H, Thomas CE, Storm TA, Fuess S, Matsushita T, Allen J, Surosky R, Lochrie M, Meuse L, McClelland A, Colosi P, Kay MA. 2003. Pre-clinical in vivo evaluation of pseudotyped adeno-associated virus (AAV) vectors for liver gene therapy. Blood 102: 2412-2419
Address
Department of Infectious Diseases, Virology,
Medical Faculty, Heidelberg University
Im Neuenheimer Feld 267
69120 Heidelberg
eMail
dirk.grimm@bioquant.uni-heidelberg.de