Scientific Vita
Publi­cations
Con­tact

PD Dr.

Dirk Wohlleber

Academic Education and University Degrees

2003 - 2006
Ph.D. work, Biochemistry, Interfakultäres Institut für Biochemie, Tübingen, Germany supervised by Prof. Probst
2003 - 2003
Diploma work, Biochemistry, Interfakultäres Institut für Biochemie, Tübingen, Germany supervised by Prof. Probst
1998 - 2003
Study of Biochemistry at the University of Tübingen, Germany

Employment

2019 - today
Independent group leader at the Institute of Molecular Immunology, Technical University of Munich
Since 04/2014
Research group leader at the Institute of Molecular Immunology, Technische Universität München, Germany
2006 – 2014
Postdoc at the Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Germany
Schneider A, Kurz S, Manske K, Janas M, Heikenwalder M, Misgeld T, Aichler M, Weissmann S, Zischka H, Knolle PA, Wohlleber D. Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection. Scientific reports. 11;9(1):8492.
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, Hösslin M, Cullen J, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen C, Thimme R*, Youngblood B*, Zehn D*. 2019. Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection. Nature. 2019 571(7764):265-269. (*co-corresponding authors)
Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P*, Wohlleber D*, Kastenmüller W*. 2018. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 9(1):4805. (*equal contribution)
Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D. 2018. Outcome of Antiviral Immunity in the Liver is Shaped by the Level of Antigen Expressed in Infected Hepatocytes. Hepatology. 68(6):2089.
Schölzel K, Schildberg FA, Börner C, Geiger S, Kurts C, Heikenwälder M, Knolle PA, Wohlleber D. 2014. Cross-allocation of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance. J Hepatol. 61(3):600-8.
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA. 2013. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol. 14(6):574-83.
Böttcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Höchst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath MF, Busch DH, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze JL, Diehl L, Knolle PA. 2013. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell Rep. 3:779-95.
Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA. 2012. TNF-induced target cell killing by CTL activated through cross-presentation. Cell Rep. 2:478-87.
Böttcher JP, Knolle PA, Stabenow D. 2011. Mechanisms balancing tolerance and immunity in the liver. Dig Dis. 29(4):384-90.
Stabenow D, Frings M, Trück C, Gärtner K, Föerster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrant K, Protzer U, Knolle PA. 2010. Bioluminescence imaging allows measuring CD8 T cell function in the liver. Hepatology. 51:1430-7.
Address
Institute of Molecular Immunology and Experimental Oncology
Klinikum rechts der Isar
Technische Universität München
Trogerstr. 9
81675 München
eMail
dirk.wohlleber@tum.de