Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Ulrike Protzer

Academic Education and University Degrees

2005
Board Exam „Microbiology and Virology“
2002 - 2005
Training in Medical Microbiology, University Hospital Cologne,Germany
1996
Board exam „Internal Medicine“; Clinical training, University Hospital Mainz, Germany
1992 - 1996
Clinical training, University Hospital Mainz, Germany
1990 - 1991
“Arzt im Praktikum”, MD, full approbation as clinician
1982 - 1988
Medical School, University of Erlangen, Germany

Employment

Since 11/2007
Full professor (W3) and Chair of Virology, TUM Since 11/2007 Director Institute of Virology, TUM / HMGU
2002 - 2007
Junior group leader “Molecular Infectiology” at the Center for Molecular Medicine Cologne, Germany
1996- 2000
Postdoctoral scientist, Center of Molecular Biology Heidelberg, Germany Department “Virus – host interaction of hepatitis B virus” (H. Schaller)
Wisskirchen K*, Kah J*, Malo A, Asen T, Volz T, Allweiss L, Wettengel JM, Lütgehetmann M, Urban S, Bauer T, Dandri M*, Protzer U*. 2019. T-Cell Receptor Grafting allows Virological Control of Hepatitis B Virus Infection. J Clin Invest. 30: 130. Doi 10.1172/JCI120228. (*equal contribution)
Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. 2018. Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. 2018. Journal of Hepatology. 69(6):1231-1241. doi: 10.1016/j.jhep.2018.08.012.
Burwitz B°, Wettengel J°, Mück-Häusl M°, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Reed N, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U*, Sacha J*. 2017. Hepatocytic Expression of Human Sodium-Taurocholate Cotransporting Polypeptide Enables Hepatitis B Virus Infection of Macaques. Nature Communications. 15; 8 (1): 2146. (*work jointly supervised by)
Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwalder M, Protzer U*, Grimm D*. 2016. Blocking sense strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO Mol Medicine. 8(9):1082-98. (*equal contribution)
Xia Y*, Stadler D*, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chao W-M, Wettengel J, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Thasler WE, Heikenwalder M and Protzer U. 2016. Interferon-γ and Tumor Necrosis Factor-α Produced by T cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology. 150:194-202. (*equal contribution)
Lucifora J*, Xia Y*, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl M, Koppensteiner H, Li Y, Makowska Z, Volz T, Remouchamps C, Chou W-M, Thasler W, Hüser N, Durantel D, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M*, Protzer U*. 2014. Specific and non-hepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 343: 1121-1128. (*equal contribution)
Bohne F, Londoño M-C, Benítez C, Miquel R, Martínez-Llordella M, Russo C, Ortiz C, Bonaccorsi-Riani E, Brander C, Bauer T, Protzer U, Jaeckel E, Taubert R, Forns X, Navasa M, Berenguer M, Rimola A, Lozano J-J, Sánchez-Fueyo A. 2014. Role of HCV-induced immune responses on the establishment of operational tolerance following liver transplantation in humans. Sci Transl Med. 6:242ra81.
Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U. 2013. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology. 145:456-65.
Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U. 2012. Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology. 142:1447-50.
Protzer U, Nassal M, Chiang PW, Kirschfink M, Schaller H. 1999. Interferon gene transfer by a novel hepatitis B virus vector efficiently suppresses wildtype-virus infection. Proc Natl Acad Sci U S A 96: 10818-10823.
Address
Institute of Virology
Technische Universität München
Trogerstr. 30
81675 München
eMail
protzer@tum.de