Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Christoph Neumann-Haefelin

Clinical education and employment

Since 2024
W3-Professor and Director of the Clinic and Polyclinic for Gastroenterology and Hepatology at the University Hospital Cologne and the Medical Faculty of the University of Cologne
Since 2021
Associate Professor (APL) for Internal Medicine
since 2013
Head of Gerok-Liver Center Freiburg, Medical Center – University of Freiburg
since 2011
Attending in Internal Medicine, Department of Medicine II, University Hospital Freiburg, Germany
2011
Internal Medicine Board exam
2003
MD at the Department of Medicine II, University Hospital Freiburg, Germany (Director: Prof. Dr. Dres. h.c. H.E. Blum; since 2013 Prof. Dr. R. Thimme)
2003
Clinical observer (PJ), University of South Florida, Tampa, USA, and Kantonsspital Winterthur, Switzerland
1996 - 2003
Medical student, Albert Ludwigs University Freiburg, Germany

Scientific education

2012
Habilitation in Medicine, Albert Ludwigs University Freiburg, Germany since 2010 Emmy Noether Group leader, Department of Medicine II, University Hospital Freiburg, Germany
2009
Sabbatical at the Ragon Institute of MGH, MIT, and Harvard, Boston, USA (group of Prof. Todd M. Allen)
2003 - 2009
Research Associate in the group of Prof. Dr. R. Thimme, Department of Medicine II, University Hospital Freiburg, Germany
1998 - 2001
Doctoral thesis in the group of Prof. Dr. M. Müller, Institute of Biochemistry, University of Freiburg, Germany (grade: summa cum laude)
1. Kemming J, Gundlach S, Panning M, Huzly D, Huang J, Lütgehetmann M, Pischke S, Schulze zur Wiesch J, Emmerich F, Llewellyn-Lacey S, Price DA, Tanriver Y, Warnatz K, Boettler T, Thimme R, Hofmann M, Fischer N, Neumann-Haefelin C. (2022) Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection. J Hepatol. 77:978-990. doi: 10.1016/j.jhep.2022.05.019.
2. Lang-Meli J*, Luxenburger H*, Wild K*, Karl V*, Oberhardt V*, Salimi Alizei E, Graeser A, Reinscheid M, Roehlen N, Reeg DB, Giese S, Ciminski K, Götz V, August D, Rieg S, Waller CF, Wengenmayer T, Staudacher D, Huzly D, Bengsch B, Kochs G, Schwemmle M, Emmerich F, Boettler T#, Thimme R#, Hofmann M#, Neumann-Haefelin C#. (2022) SARS-CoV-2 CD8+ T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals. Nat Microbiol. 7:675-679. doi: 10.1038/s41564-022-01106-y *equal contribution. #joint senior authors.
3. Oberhardt V*, Luxenburger H*, Kemming J*, Schulien I*, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R#, Neumann-Haefelin C#, Hofmann M#. (2021) Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine. Nature. 597: 268-273. doi: 10.1038/s41586-021-03841-4. *equal contribution. #joint senior authors.
4. Schulien I*, Kemming J*, Oberhardt V*, Wild K*, Seidel LM*, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T#, Bengsch B#, Thimme R#, Hofmann M#, Neumann-Haefelin C#. (2021) Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nat Med. 27: 78-85. doi: 10.1038/s41591-020-01143-2. *equal contribution. #joint senior authors.
5. Kemming J*, Reeves E*, Nitschke K, Widmeier V, Emmerich F, Hermle T, Gostick E, Walker A, Timm J, Price DA, Hofmann M, Thimme R, James E#, Neumann-Haefelin C#. (2019) ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection. J Hepatol. 70: 1072-1081. doi: 10.1016/j.jhep.2019.01.034. *equal contribution. #joint senior authors.
6. Karimzadeh H*, Kiraithe MM*, Oberhardt V*, Salimi Alizei E, Bockmann J, Schulze zur Wiesch J, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M#, Neumann-Haefelin C#. (2019) Mutations in hepatitis D virus allow it to escape detection by CD8+ T cells and evolve at the population level. Gastroenterology. 156: 1820-1833. doi: 10.1053/j.gastro.2019.02.003. *equal contribution. #joint senior authors.
7. Nitschke K, Barriga A, Schmidt J, Timm J, Viazov S, Kuntzen T, Kim AY, Lauer GM, Allen TM, Gaudieri S, Rauch A, Lange CM, Sarrazin C, Eiermann T, Sidney J, Sette A, Thimme R, López D, Neumann-Haefelin C. (2014) HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. J Hepatol. 60: 22-29. doi: 10.1016/j.jhep.2013.08.009.
8. Schmidt J, Iversen AK, Tenzer S, Gostick E, Price DA, Lohmann V, Distler U, Bowness P, Schild H, Blum HE, Klenerman P, Neumann-Haefelin C#, Thimme R#. (2012) Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope. PLoS Pathog. 8:e1003042. doi: 10.1371/journal.ppat.1003042. #joint senior authors.
9. Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM. (2011) Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology. 54:1157-1166. doi: 10.1002/hep.24541.
10. Dazert E*, Neumann-Haefelin C*, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. (2009) Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 119:376-386. doi: 10.1172/JCI36587.
Address
Klinik und Poliklinik für Gastroenterologie und Hepatologie
Uniklinik Köln
Kerpener Str. 62
50937 Köln
eMail
christoph.neumann-haefelin@uniklinik-freiburg.de