Scientific Vita
Publi­cations
Con­tact

Dr.

Shirin Nkongolo

since 2024
Clinician-Scientist / Physician (Specialist for Internal Medicine), Heidelberg University Hospital, Internal Medicine IV: Gastroenterology, Hepatology and Infectious Diseases; and Center for Infectious Diseases, Molecular Virology
2022 – 2024
Physician in training, Heidelberg University Hospital
2019 – 2022
Postdoctoral Fellow, University Health Network, Toronto Centre for Liver Disease (research group Gehring)
2016 – 2019
Physician in training / Clinician-Scientist, University Hospital Heidelberg
2016
Research Stay, Institut Pasteur Paris, Département Virology (research group Vignuzzi)
1. Nkongolo S, Mahamed D, Kuipery A, Sanchez Vasquez JD, Kim SC, Mehrotra A, Patel A, Hu C, McGilvray I, Feld J, Fung S, Chen D, Wallin J, Gaggar A, Janssen HLA*, Gehring AJ*. (2023) Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells. J Clin Invest. 133(1):e158903. doi: 10.1172/JCI158903. *equal contribution.
2. Genshaft AS*, Subudhi S*, Keo A*, Sanchez Vasquez JD*, Conceição-Neto N*, Mahamed D, Boeijen L, Alatrakchi N, Oetheimer C, Vilme M, Drake R, Fleming I, Tran N, Tzouanas C, Joseph-Chazan J, Arreola Villanueva M, van de Werken HJG, van Oord GW, Groothuismink ZMA, Beudeker BJ, Osmani Z, Nkongolo S, Mehrotra A, Feld JJ, Chung RT, de Knegt RJ, Janssen HLA, Aerssens J, Bollekens J, Hacohen N, Lauer GM*, Boonstra A*, Shalek AK*, Gehring A*. (2023) Clinical implementation of single-cell RNA sequencing using fine needle aspirate tissue sampling and centralized processing captures compartment specific immunodiversity. Hepatology. Online ahead of print. doi: 10.1097/HEP.0000000000000438. *equal contribution.
3. Kuipery A, Mahamed D, Nkongolo S, D’Angelo JA, Johnson-Valiente A, Mehrotra A, Chapman WC, Horton P, McGilvray I, Janssen HLA, Gehring AJ. (2022) The human male liver is predisposed to inflammation via enhanced myeloid responses to inflammatory triggers. Front Immunol. 13:818612. doi: 10.3389/fimmu.2022.818612.
4. Nkongolo S, Mohr I, Wenzel JJ, Khalid D, Mieth M, Mehrabi A, Weiss KH, Schnitzler P. (2022) Hepatitis E seroprevalence, cases and management in a large German centre for liver transplantation. Liver Cancer International. 3(2):72-81. doi: 10.1002/lci2.48.
5. Lempp FA, Roggenbach I, Nkongolo S, Sakin V, Schlund F, Schnitzler P, Wedemeyer H, Le Gal F, Gordien E, Yurdaydin C, Urban S. (2021) A rapid point-of-care test for the serodiagnosis of hepatitis delta virus infection. Viruses. 13:1371. doi: 10.3390/v13122371.
6. Nkongolo S*, Nussbaum L*, Lempp FA, Wodrich H, Urban S, Ni Y. (2019) The retinoic acid receptor (RAR) α-specific agonist Am80 (tamibarotene) and other RAR agonists potently inhibit hepatitis B virus transcription from cccDNA. Antiviral Res. 168:146-155. doi: 10.1016/j.antiviral.2019.04.009. *equal contribution.
7. Nkongolo S*, Ni Y*, Lempp FA, Kaufman C, Lindner T, Esser-Nobis K, Lohmann V, Mier W, Mehrle S, Urban S. (2014) Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. J Hepatol. 60(4):723-731. doi: 10.1016/j.jhep.2013.11.022. *equal contribution.
8. Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, Sültmann H, Urban S.(2014) Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology. 146(4):1070-1083. doi: 10.1053/j.gastro.2013.12.024.
Address
Molecular Virology, Translational Virology
Heidelberg University Hospital
Im Neuenheimer Feld 344
69120 Heidelberg

and
Internal Medicine IV (Gastroenterology, Hepatology, Infectious Diseases)
Phone
06221 56 310229
eMail
Shirin.Nkongolo@med.uni-heidelberg.de