Scientific Vita

Prof. Dr.

Robert Thimme

Academic Education and University Degrees
Certificate Endocrinology
Habilitation in Internal Medicine, mentor Prof. Hubert E. Blum , University Hospital Freiburg, Germany
Certificate Gastroenterology
Certificate Gastroenterologic Oncology, DGVS
1998 - 2001
Postdoctoral fellowship at the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
1993 - 1994
Dissertation in the department of Virology, Albert-Ludwigs University of Freiburg, Germany grade: summa cum laude; supervised by Prof. Dr. Otto Haller
3. State Examination, Graduation in Human Medicine, Grade: summa cum laude
1991 - 1996
Study of Medicine at Albert-Ludwigs University of Freiburg, Germany
1989 - 1991
Study of Medicine at Free University of Berlin, Germany
Since 2013
Clinical Director, Department of Internal Medicine II
2012 - 2013
Assistant Medical Director, Department of Internal Medicine II
2009 - 2013
Head of the newly founded Liver Centre of Freiburg, Germany
2009 -
Heisenberg Professorship W2 / W3 in Hepatology
2007 - 2013
Leading attending at Department of Internal Medicine II, University of Freiburg, Germany
2005 - 2009
Junior Professorship for Hepatitis Viral Infection
2001 - 2005
Special training in Gastroenterology at Department of Internal Medicine II, University of Freiburg, Germany
1996 - 1998
Medical Doctor at Department of Internal Medicine II, University of Freiburg, Germany
1. Hensel N, …, Bengsch B, Boettler T, Neumann-Haefelin C, Eils R, Conrad C, Bartenschlager R, Grün D, Ishaque N, Thimme R*, Hofmann M.* (2021) Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection. Nat Immunol. 22(2),229-239; doi: 10.1038/s41590-020-00817-w. *equal corresponding authors.
2. Oberhardt V, Luxenburger H, …, Bengsch B, …, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R*, Neumann-Haefelin C*, Hofmann M*. (2021) Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine. Nature. 597(7875),268-273; doi: 10.1038/s41586-021-03841-4. *equal corresponding authors.
3. Schulien I, …, Luxenburger H, …, Boettler T, Bengsch B, Thimme R*, Hofmann M*, Neumann-Haefelin C*. (2021) Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nat Med. 27(1),78-85; doi: 10.1038/s41591-020-01143-2. *equal corresponding authors.
4. Heim K, …, Boettler T, Neumann-Haefelin C, Zehn D, Bengsch B, Hofmann M, Thimme R. (2020) TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut. 70(8),1550-1560; doi:10.1136/gutjnl-2020-322404.
5. Alfei F, Kanev K, Hofmann M, …, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R*, Youngblood B*, Zehn D*. (2019) TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature. 571(7764), 265-269; doi:10.1038/s41586-019-1326-9. *equal corresponding authors.
6. Schuch A, …, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M*, Thimme R*. (2019) Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut. 68(5), 905-915; doi: 10.1136/gutjnl-2018-316641. *equal corresponding authors.
7. Wieland D, …, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R. (2017) TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 8,15050; doi:10.1038/ncomms15050.
8. Dazert E, Neumann-Haefelin C, …, Bartenschlager R, Thimme R. (2009) Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 119(2),376-386; doi:10.1172/jci36587.
9. Thimme R, … Chisari FV. (2002) Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci U S A. 99(24),15661-15668; doi:10.1073/pnas.202608299.
10. Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. (2001) Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med. 194(10),1395-1406; doi:10.1084/jem.194.10.1395.
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg, Germany