Scientific Vita

Prof. Dr.

Robert Thimme

Academic Education and University Degrees
Certificate Endocrinology
Habilitation in Internal Medicine, mentor Prof. Hubert E. Blum , University Hospital Freiburg, Germany
Certificate Gastroenterology
Certificate Gastroenterologic Oncology, DGVS
1998 - 2001
Postdoctoral fellowship at the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
1993 - 1994
Dissertation in the department of Virology, Albert-Ludwigs University of Freiburg, Germany grade: summa cum laude; supervised by Prof. Dr. Otto Haller
3. State Examination, Graduation in Human Medicine, Grade: summa cum laude
1991 - 1996
Study of Medicine at Albert-Ludwigs University of Freiburg, Germany
1989 - 1991
Study of Medicine at Free University of Berlin, Germany
Since 2013
Medical Director, Department of Internal Medicine II
2012 - 2013
Assistant Medical Director, Department of Internal Medicine II
2009 - 2013
Head of the newly founded Liver Centre of Freiburg, Germany
2009 -
Heisenberg Professorship W2 / W3 in Hepatology
2007 - 2013
Leading attending at Department of Internal Medicine II, University of Freiburg, Germany
2005 - 2009
Junior Professorship for Hepatitis Viral Infection
2001 - 2005
Special training in Gastroenterology at Department of Internal Medicine II, University of Freiburg, Germany
1996 - 1998
Medical Doctor at Department of Internal Medicine II, University of Freiburg, Germany
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, Hösslin M, Cullen J, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen C, Thimme R*, Youngblood B*, Zehn D*. 2019. Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection. Nature. 2019 571(7764):265-269. (*co-corresponding authors)
Schuch A, Salimi Alizei E*, Heim K*, Wieland D, Muthamia Kiraithe M, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M*, Thimme R*. 2019. Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut. 68(5):905-915. (*equal contribution)
Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M*, Thimme R*. 2017. TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 8:15050. (*equal contribution)
Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W. 2016. T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. Immunity. 45(2):415-27.
Martin B, Hennecke N, Lohmann V, Kayser A, Neumann-Haefelin C, Kukolj G, Böcher WO, Thimme R. 2014. Restoration of HCV-specific CD8+ T-cell function by Interferon-free therapy. J Hepatol. 61(3):538-43.
Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R. 2013. Factors that determine the antiviral efficacy of HCV-specific CD8+ T cells ex vivo. Gastroenterology. 144(2): 426-36.
Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. 2010. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 6: e1000947.
Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. 2009. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 119(2): 376-86.
Jo J, Aichele U, Kersting N, Klein R, Aichele P, Bisse E, Sewell AK, Blum HE, Bartenschlager R, Lohmann V, Thimme R. 2009. Analysis of CD8+ T cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology. 136(4):1391-401.
Thimme R, Bukh J, Spangenberg HC, Wieland S, Pemberton J, Steiger C, Govindarajan S, Purcell RH, Chisari FV. 2002. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci U S A. 99(24): 15661-8.
Department of Medicine II
University Hospital Freiburg
Hugstetter Str. 55
79106 Freiburg, Germany