Scientific Vita


Maike Hofmann

Academic Education and University Degrees

2007 - 2012
Ph.D. thesis, Molecular Medicine / Immunology, Institute of Immunology, Medical Center – University of Freiburg, Germany supervised by Prof. Dr. Hanspeter Pircher
Diploma thesis, Molecular Medicine, Institute of Immunology, Medical Center- University of Freiburg, Germany supervised by Prof. Dr.Hanspeter Pircher
2002 - 2007
Studies in Molecular Medicine, University of Freiburg, Germany


Since 2016
Group Leader, Department of Medicine II - Gastroenterology, Hepatology, Endocinology and Infectious Diseases, Medical Center - University of FreiburgSince 2014 - 2016
2014 - 2014
Postdoc, University spin-off cytena / Department for Microsystems Engineering, University of Freiburg, Germany
2012 - 2014
Postdoc, Institute of Immunology, Medical Center - University of Freiburg, Germany
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, Hösslin M, Cullen J, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen C, Thimme R*, Youngblood B*, Zehn D*. 2019. Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection. Nature. 2019 571(7764):265-269. (*co-corresponding authors)
Schuch A, Salimi Alizei E*, Heim K*, Wieland D, Muthamia Kiraithe M, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M*, Thimme R*. 2019. Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut. 68(5):905-915. (*equal contribution)
Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Böttler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M. 2019. NK-cell responses are based towards CD16-mediated effector functions in chronic hepatitis B virus infection. J Hepatol. 70(3):351-360.
Provine NM*, Binder B*, FitzPatrick MEB, Schuch A, Garner LC, Williamson KD, van Wilgenburg B, Thimme R, Klenerman P, Hofmann M. 2018. Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells. Front Immunol. 9:756. (*equal contribution)
Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M*, Thimme R*. 2017. TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation. Nat Commun. 8:15050. (*equal contribution)
Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W. 2016. T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. Immunity. 45(2):415-27.
Hofmann M, Oschowitzer A, Kurzhals SR, Krüger CC, Pircher H. 2013. Thymus-resident memory CD8+ T cells mediate local immunity. Eur J Immunol. 43(9):2295-304.
Hofmann M, Schweier O, Pircher H. 2012. Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations. Eur J Immunol. 42(9):2484-90.
Hofmann M, Pircher H. 2011. E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands. Proc Natl Acad Sci USA. 108(40):16741-6.
Li Y, Hofmann M, Wang Q, Teng L, Chlewicki LK, Pircher H, Mariuzza RA. 2009. Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity. 31(1):35-46.
Department of Medicine II,
University Hospital Freiburg
79106 Freiburg