Scientific Vita
Publi­cations
Con­tact

Dr.

Jochen Martin Wettengel

Academic Education and University Degrees
Since 04/2017
Technical University of Munich, Institute of Virology, Doctoral studies: Translational medicine (Dr. med. sci.); Topic: Generation and production of recombinant hepatitis B virus for monitoring of infection and single-cell selection
2013 – 2019
Technical University of Munich, Institute of Virology; PhD studies: Experimental medicine (Dr. rer. nat.); Topic: Tropism- and species determining factors of the hepatitis B virus
2012 – 2019
Ludwig Maximilian University of Munich and Technical University of Munich, Studies: Medicine
2010 – 2012
Technical University of Munich, Studies: Molecular Biotechnology, Degree: Master of Science; Topic: Investigation of the intracellular transport of fluorescent labeled hepatitis B virus particles in human macrophages
2007 – 2010
Technical University of Munich, Studies: Molecular Biotechnology, Degree: Bachelor of Science; Topic: Assembly of constructs for RNAi-mediated gene silencing in plants
Employment
Since 2020
Joint-Position on an NIH-Grant - Postdoctoral fellow at the Vaccine Gene & Therapy Institute (Prof. Burwitz) at the Oregon Health & Science University, Portland, USA & Resident physician at the Institute of Virology (Prof. Protzer) of the Technical University of Munich
2019 – 2020
Postdoctoral fellow at the Vaccine Gene & Therapy Institute (Prof. Burwitz) at the Oregon Health & Science University, Portland, USA
2019 – 2019
Resident physician at the Institute of Virology (Prof. Protzer) of the Technical University of Munich
2012 – 2019
Research associate at the Institute of Virology (Prof. Protzer) of the Technical University of Munich
1. Wettengel JM, Hansen-Palmus L, Yusova S, Rust L, Biswas S, Carson J, Ryu J, Bimber BN, Hennebold JD, Burwitz BJ. (2023) A Multifunctional and Highly Adaptable Reporter System for CRISPR/Cas Editing. Int J Mol Sci. 24(9):8271. doi: 10.3390/ijms24098271.
2. Esser K, Cheng X, Wettengel JM, Lucifora J, Hansen-Palmus L, Austen K, Suarez AAR, Heintz S, Testoni B, Nebioglu F, Pham MT, Yang S, Zernecke A, Wohlleber D, Ringelhan M, Broxtermann M, Hartmann D, Hüser N, Mergner J, Pichlmair A, Thasler WE, Heikenwalder M, Gasteiger G, Blutke A, Walch A, Knolle PA, Bartenschlager R, Protzer U. (2023) Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes. Cell Mol Gastroenterol Hepatol. Apr 11:S2352-345X(23)00051-6. doi: 10.1016/j.jcmgh.2023.03.011.
3. Tu T, Zehnder B, Wettengel JM, Zhang H, Coulter S, Ho V, Douglas MW, Protzer U, George J, Urban S. (2022) Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells. JHEP Rep. 4(9):100514. doi: 10.1016/j.jhepr.2022.100514.
4. Biswas S, Rust LN, Wettengel JM, Yusova S, Fischer M, Carson JN, Johnson J, Wei L, Thode T, Kaadige MR, Sharma S, Agbaria M, Bimber BN, Tu T, Protzer U, Ploss A, Smedley JV, Golomb G, Sacha JB, Burwitz BJ. (2022) Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity. Nat Commun. 13(1):2995. doi: 10.1038/s41467-022-30593-0.
5. Oswald A, Chakraborty A, Ni Y, Wettengel JM, Urban S, Protzer U. (2021) Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus. Sci Rep. 11(1):19799. doi: 10.1038/s41598-021-99263-3.
6. Wettengel JM, Linden B, Esser K, Laue M, Burwitz BJ, Protzer U. (2021) Rapid and Robust Continuous Purification of High-Titer Hepatitis B Virus for In Vitro and In Vivo Applications. Viruses. 13(8):1503. doi: 10.3390/v13081503.
7. Quitt O, Luo S, Meyer M, Xie Z, Golsaz-Shirazi F, Loffredo-Verde E, Festag J, Bockmann JH, Zhao L, Stadler D, Chou WM, Tedjokusumo R, Wettengel JM, Ko C, Noeßner E, Bulbuc N, Shokri F, Lüttgau S, Heikenwälder M, Bohne F, Moldenhauer G, Momburg F, Protzer U. (2021) T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice. J Hepatol. 75(5):1058-1071. doi: 10.1016/j.jhep.2021.06.022.
8. Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenberger C, Schneider M, Heßling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwalder M. (2021) Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence. Hepatology. 74(4):1766-1781. doi: 10.1002/hep.31902.
9. Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. (2018) Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. J Hepatol. 69(6):1231-1241. doi: 10.1016/j.jhep.2018.08.012.
10. Burwitz BJ*, Wettengel JM*, Mück-Häusl MA*, Ringelhan M, Ko C, Festag MM, Hammond KB, Northrup M, Bimber BN, Jacob T, Reed JS, Norris R, Park B, Moller-Tank S, Esser K, Greene JM, Wu HL, Abdulhaqq S, Webb G, Sutton WF, Klug A, Swanson T, Legasse AW, Vu TQ, Asokan A, Haigwood NL, Protzer U, Sacha JB. (2017) Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques. Nat Commun. 8(1):2146. doi: 10.1038/s41467-017-01953-y. *equal contribution.
Address
Institute of Virology
Technische Universität München
Trogerstr. 30
81675 München
eMail
Wettengel@tum.de