Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Percy A. Knolle

Academic Education and University Degrees
2000
Habilitation, University of Heidelberg, Heidelberg, Germany, mentor Prof.Meuer
1997
“Facharzt für Innere Medizin”
1992 - 1997
Assistant 1st Medical Clinic, University of Mainz, Prof. Meyer zum Büschenfelde, Mainz, Germany
1991 - 1992
Postdoc with BASF-Research Branch in Boston, USA
1989 - 1991
Experimental MD, German Cancer Research Center; supervised by Prof.Meuer, Heidelberg, Germany
1982 - 1988
Study of Medicine at the Universities of Frankfurt, Birmingham, Paris, Geneva, Strasbourg

Employment
Since 2013
Director Institute of Molecular Immunology and Experimental Oncology, Technische Universität München, Germany
2002 - 2012
Director Institute of Molecular Medicine, University of Bonn, Germany
1997 - 2002
Independent group leader at ZMBH (Prof. Schaller), Heidelberg, Germany
1992 - 1997
Assistant 1st Medical Clinic, University of Mainz, Prof. Meyer zum Büschenfelde, Germany
Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle PA*, Wohlleber D*, Kastenmuller W*. 2018. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 9(1): 4805. (*equal contribution)
Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Forster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmuller W, Knolle PA*, Abdullah Z*. 2017. Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut 66(3): 507-518. (*equal contribution)
Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Kohne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwälder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA*, Schultze JL*. 2016. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol. 17(5): 593-603. (*equal contribution)
Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA. 2015. Functional classification of memory CD8(+) T cells by CX3CR1 expression. Nat Commun. 6: 8306.
Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschop M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle PA*, Weber A*, Heikenwälder M*. 2014. Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes. Cancer cell. 26: 549-564. (*equal contribution)
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwälder M, Knolle PA. 2013. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol. 14(6): 574-583.
Böttcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Hochst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath MF, Busch DH, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze JL, Diehl L, Knolle PA. 2013. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell reports. 3: 779-795.
Wohlleber D, Kashkar H, Gartner K, Frings MK, Odenthal M, Hegenbarth S, Borner C, Arnold B, Hammerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwälder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Kronke M, Knolle PA. 2012. TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell reports. 2(3): 478-487.
Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase MJ, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle PA. 2010. Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology. 138(1): 336-346.
Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, Groettrup M, Momburg F, Arnold B, Knolle PA. 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med. 6(12): 1348-1354.
Address
Institute of Molecular Immunology and Experimental Oncology
Klinikum München rechts der Isar der TUM
Ismaningerstr. 22
81675 München
eMail
percy.knolle@tum.de