Scientific Vita
Publi­cations
Con­tact

Prof. Dr.

Karsten Rippe

Academic Education and University Degrees
Since 2018
Professor (W3) at the University of Heidelberg
Since 2017
Head of the Division of Chromatin Networks at the DKFZ and the Bioquant Center, Heidelberg
2007 - 2017
Head of the Research Group Genome Organization & Function at the DKFZ and the Bioquant, Heidelberg
2001 - 2007
Group leader of the Molecular Biophysics Group at the Kirchhoff-Institut für Physik, University of Heidelberg
1994 - 2001
Scientist at the German Cancer Research Center (DKFZ) in the Divisions Biophysics of Macromolecules (head: Jörg Langowski) and Molecular Genetics (head: Peter Lichter)
1992- 1994
Postdoctoral fellow, Dept. of Chemistry and Biochemistry (head: Peter von Hippel), Institute for Molecular Biology, University of Oregon, Eugene, USA
1. Muckenhuber M, Seufert I, Müller-Ott K, Mallm JP, Klett LC, Knotz C, Hechler J, Kepper N, Erdel F, Rippe K. (2023) Epigenetic signals that direct cell type specific interferon beta response in mouse cells. Life Sci Alliance. 6,e202201823. DOI: 10.26508/lsa.202201823.
2. Trojanowski J, Frank L, Rademacher A, Mücke N, Grigaitis P, Rippe K. (2022) Transcription activation is enhanced by multivalent interactions independent of phase separation. Mol Cell. 82, 1878-1893.e3. DOI: 10.1016/j.molcel.2022.04.017
3. Frank L, Rademacher A, Mücke N, Tirier SM, Koeleman E, Knotz C, Schumacher S, Stainczyk SA, Westermann F, Fröhling S, Chudasama P, Rippe K. (2022) ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats. Nucleic Acids Res. 50,e6. DOI: 10.1093/nar/gkac113.
4. Tirier SM, Mallm J-P, Steiger S, Poos AM, Awwad M, Giesen N, Casiraghi N, Susak H, Bauer K, Baumann A, John L, Seckinger A, Hose D, Müller-Tidow C, Goldschmidt H, Stegle O, Hundemer M, Weinhold N, Raab MS, Rippe K. (2021) Subclone specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single cell transcriptomics. Nat Commun. 12,6960. DOI: 10.1038/s41467-021-26951-z.
5. Mallm JP, Windisch P, Biran A, Schumacher S, Glass R, Herold-Mende C, Meshorer E, Barbus M, Rippe K. (2020) Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to loss of DNA repair capacity. Intl J Cancer. 146,1281-1292. DOI: 10.1002/ijc.32649.
6. Erdel F, Rademacher A, Vlijm R, Tünnermann J, Schweigert E, Frank L, Yserantant K, Hummert J, Bauer C, Schumacher S, Weinmann R, Alwash AA, Normand C, Herten D-P, Engelhardt J, Rippe K. (2020) Mouse heterochromatin adopts digital compaction states without showing hallmarks of HP1-driven liquid-liquid phase separation. Mol Cell. 78,236-249.e7. DOI: 10.1016/j.molcel.2020.02.005.
7. Mallm JP, Iskar M, Ishaque N, Klett LC, Kugler SJ, Muino JM, Teif VB, Poos AM, Großmann S, Erdel F, Tavernari D, Koser SD, Schumacher S, Brors B, König R, Remondini D, Vingron M, Stilgenbauer S, Lichter P, Zapatka M, Mertens D, Rippe K. (2019) Linking aberrant chromatin features in chronic lymphocytic leukemia to deregulated transcription factor networks. Mol Syst Biol. 15,e8339. DOI: 10.15252/msb.20188339.
8. Rademacher A, Erdel F, Trojanowski J, Schumacher S, Rippe K. (2017) Real-time observation of light-controlled transcription in living cells. J Cell Sci. 130,4213-4224. DOI: 10.1242/jcs.205534.
9. Müller-Ott K, Erdel F, Matveeva A, Hahn M, Mallm JP, Rademacher A, Marth C, Zhang Q, Kaltofen S, Schotta G, Höfer T, Rippe K. (2014) Specificity, propagation and memory of pericentric heterochromatin. Mol Syst Biol. 10,746. DOI: 10.15252/msb.20145377.
10. Baum M, Wachsmuth M, Erdel F, Rippe K. (2014) Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells. Nat Commun. 5,4494. DOI: 10.1038/ncomms5494.
Address
Chromatin-Netzwerke
Deutsches Krebsforschungszentrum & BioQuant
Im Neuenheimer Feld 267 - BQ 24
69120 Heidelberg
Phone
+49-6221-54-51376
eMail
Karsten.Rippe@bioquant.uni-heidelberg.de