Scientific Vita

Prof. Dr.

Dirk Grimm

Academic Education and University Degrees
2001 - 2007
Postdoctoral fellow / Research associate, Stanford University School of Medicine, Stanford, CA, USA, laboratory of Prof. Dr. Mark Kay
1999 - 2001
Postdoctoral fellow, Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany supervised by Dr. Jürgen Kleinschmidt
1995 - 1998
Ph.D. work, Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany (Grade: summa cum laude) supervised by Dr.Jürgen Kleinschmidt
1994 - 1994
Diploma work, Biology, German Cancer Research Center, Heidelberg, Germany supervised by Prof. Dr. Walter Pyerin
1988 - 1994
Study of Biology at Kaiserslautern & Heidelberg Universities, Germany

2017 - present
Full professor for viral vector technologies, Heidelberg University Hospital
2007 - 2017
Research group leader at the Department of Infectious Diseases/Virology and Cluster of Excellence CellNetworks
Bubeck F, Hoffmann M, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer M, Börner K, Fakhiri J, Schmelas S, Dietz L, Grimm D, Correia B, Eils R, Niopek D. 2018. Engineered anti-CRISPR proteins for optogenetic control of CRISPR/Cas9. Nat Methods. 15:924-927.
Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D. 2018. AAV vector-mediated in vivo reprogramming into pluripotency. Nat Commun. 9:2651.
Senís E, Mockenhaupt S, Rupp D, Bauer T, Paramasivam N, Knapp B, Gronych J, Grosse S, Windisch M, Schmidt F, Theis F, Eils R, Lichter P, Schlesner M, Bartenschlager R, Grimm D. 2017. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 45:e3.
Michler T, Grosse S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Heikenwälder M, Protzer U, Grimm D. 2016. Sense strand neutralisation improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO Mol Med. 8:1082-1098.
Rezvani M, Espanol-Suner R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman J, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Covera CU, Grimm D, Willenbring H. 2016. In vivo reprogramming of myofibroblasts into hepatocytes as a therapeutic strategy for liver fibrosis. Cell Stem Cell. 18:809-816.
Mockenhaupt S, Grosse S, Rupp D, Bartenschlager R, Grimm D. 2015. Alleviation of off-target effects from vector-encoded shRNAs via co-delivered RNA decoys. PNAS. 112: E4007-E4016.
Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh S, Börner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D. 2010. Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in mice. Mol Ther. 18:161-170.
Grimm D, Wang L, Lee JS, Schürmann N, Gu S, Börner K, Storm TA, Kay MA. 2010. Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. J Clin Invest. 120:3106-3119.
Grimm D, Lee JS, Wang L, Desai T, Akache B, Storm TA, Kay MA. 2008. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and re-targeting of adeno-associated viruses. J Virol. 82:5887-5911.
Grimm D, Streetz KS, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA. 2006. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 441:537-541.
Department of Infectious Diseases, Virology,
Medical Faculty, Heidelberg University
Im Neuenheimer Feld 267
69120 Heidelberg